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Not Only Lipids and Inflammation: Insight Into a New Cause of Heart Attack and Other Vascular Disease
Date:1/6/2008

sting the participation of academic researchers and thousands of their patients from Iceland, New Zealand, the Netherlands, Finland, the US, Belgium, Sweden, Italy, Denmark and the UK - analyzed the association of the variant with several other cardiovascular conditions. The results show that the 'G' allele is suggestively but not definitively associated with conditions involving the buildup of atherosclerotic plaque, including peripheral artery disease and large artery stroke. However those with one copy of this version of the SNP had a more than 30% greater risk of both AAA and IA than non- carriers. Those with two copies - that is, who inherited the risk variant form both parents - were at more than 70% greater risk of both AAA and IA than were non-carriers. What heart attack and these types of aneurysm have in common is that all three can result from an abnormal or deficient remodeling and/or repair of vessel walls.

The U.S. National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) supported the recruitment of AAA sample sets and controls from Belgium, Canada and Pennsylvania. In addition, the Finnish intracranial aneurysm sample collection was funded in part by NIH's National Institute of Neurological Disorders and Stroke.

About deCODE

deCODE is a biopharmaceutical company applying its discoveries in human genetics to the development of drugs and diagnostics for common diseases. deCODE is a global leader in gene discovery - our population approach and resources have enabled us to isolate key genes contributing to major public health challenges from cardiovascular disease to cancer, genes that are providing us with drug targets rooted in the basic biology of disease. deCODE is also leveraging its expertise in human genetics and integrated drug discovery and development capabilities to offer innovative products and services in DNA-based diagnostics, bioinformatics, genotyping, structural biology, drug discov
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SOURCE deCODE genetics Inc.
Copyright©2008 PR Newswire.
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