Navigation Links
Northwestern Memorial Study Tests Cancer Drug on Scleroderma Patients
Date:3/6/2008

Study Seeks Treatment to Address Skin Hardening Affects of the Devastating Disease

CHICAGO, March 6 /PRNewswire-USNewswire/ -- Physicians at Northwestern Memorial Hospital are studying the effects of an anti-cancer drug to treat patients with scleroderma, a rare, incurable autoimmune rheumatic disease that leads to hardening and tightening of the skin and connective tissues. Scleroderma affects an estimated 300,000 people in the United States and can often attack the lungs, heart, kidneys and intestinal tract, and sometimes lead to death.

The study is the first of its kind to examine if Gleevec, a cancer drug commonly used to treat leukemia, will treat the skin thickness in scleroderma patients by blocking the pathway that causes fibrosis. Patients enrolled in the clinical trial will receive daily oral doses of Gleevec for six months and will be evaluated initially on a weekly basis at Northwestern Memorial, one of only three centers nationwide participating in the study. Others include Johns Hopkins and Boston University Medical Center.

John Varga, MD, rheumatologist at Northwestern Memorial, John and Nancy Hughes Distinguished Professor in Rheumatology at Northwestern University's Feinberg School of Medicine and principal investigator of the study, said this could be a big step forward for people diagnosed with scleroderma. "Based on recent research performed by investigators at the Feinberg School, Gleevec shows potential efficacy in reducing the abnormal skin changes associated with scleroderma."

The exact cause of Scleroderma, a chronic disease most commonly found in women between the ages of 30 and 40, remains unknown. Through continued research, Northwestern Memorial physicians hope to identify treatments to target the disease and improve the quality of life for patients living with Scleroderma.

"We hope that the use of Gleevec for a sustained period of time will decrease the symptoms of skin hardening, and po
'/>"/>

SOURCE Northwestern Memorial Hospital
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Northwestern Offers Clinical Research and Regulatory Administration Graduate Certificate Program
2. Northwestern Memorial Transplant Program Initiates New Study
3. Bertrand Study Finds Significant Value in Breast-Specific Gamma Imaging (BSGI) as an Adjunctive Procedure in Breast Diagnostics
4. Study Finds Starion Instruments Tissue Welding Technology Safe and Effective in Parotidectomy Procedures
5. Thomson Healthcare Cancer Profiler Used in Study
6. Pharmacopeia Initiates Second Phase 2 Hypertension Study with PS433540 (DARA)
7. Genetic Variation Associated with Treatment Response in a Clinical Study of a New Atypical Antipsychotic Fiaptatm (iloperidone)
8. CMC, Moffitt Partner to Study Cancer
9. Pharmacopeia Completes Enrollment in Phase 2 Hypertension Study with PS433540 (DARA)
10. Oral Talactoferrin Alfa Improves Overall Survival in Patients With Refractory Non-Small Cell Lung Cancer: Final Phase 2 Study Results Presented at the 8th Annual Targeted Therapies for the Treatment Of Lung Cancer Meeting
11. EndoGastric Solutions(TM) Announces Results of EsophyX(TM) Multi-Center GERD Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... DIEGO , March 2, 2015  BioMed Realty ... it has recaptured approximately 313,000 square feet of space ... estate market in the world through the termination of ... Cambridge, Massachusetts effective February 28, 2015. BioMed ... Vertex and will immediately begin to reposition the properties ...
(Date:3/1/2015)... March 1, 2015  An innovative interventional radiology ... sufferers sustained relief of their headaches, according to ... Interventional Radiology ,s Annual Scientific Meeting . ... University New York Empire State College in Saratoga ... ganglion (SPG) blocks to give patients enough ongoing ...
(Date:2/27/2015)... , Feb. 27, 2015 The role of ... decade but one thing hasn,t changed: face-to-face meetings are ... relationships with Key Opinion Leaders. Yet at ... most valuable type of interaction, field medical teams within ... KOL interactions. This is just one of the challenges ...
Breaking Medicine Technology:BioMed Realty Gets Back 313,000 Square Feet Of Valuable Real Estate In Cambridge Innovation District 2BioMed Realty Gets Back 313,000 Square Feet Of Valuable Real Estate In Cambridge Innovation District 3Image-guided treatment shown to break the migraine cycle 2Image-guided treatment shown to break the migraine cycle 3Image-guided treatment shown to break the migraine cycle 4Improving the Management of MSL Teams to Create Value across a Diverse Set of Customers 2
... The Muscular Dystrophy Association today announced funding, totaling $13.7 ... nearly two dozen progressive neuromuscular diseases.  Among these are ... (DMD), nine new projects focused on ALS ... as efforts on spinal muscular atrophy (SMA), ...
... Inc., a leading manufacturer and supplier of electronic components, ... include a push-pull switch and rotary switch.  Designated the ... an extension of Bourns® Model 51/53 Series with an ... Model 56 is a new 1/2" panel control and ...
Cached Medicine Technology:Muscular Dystrophy Association Awards $13.7 Million for 40 New Research Grants 2Muscular Dystrophy Association Awards $13.7 Million for 40 New Research Grants 3Muscular Dystrophy Association Awards $13.7 Million for 40 New Research Grants 4Muscular Dystrophy Association Awards $13.7 Million for 40 New Research Grants 5Bourns Introduces Two New Industrial-Grade Panel Control Models 2Bourns Introduces Two New Industrial-Grade Panel Control Models 3
(Date:3/2/2015)... WI (PRWEB) March 02, 2015 ... consultancy focused on quality, regulatory and technical consulting, ... as Chief Operating Officer. , Before joining ... experience leading R&D teams in all aspects of ... leadership positions at Covidien (Medtronic), Regulatory Compliance Associates ...
(Date:3/2/2015)... 2015 The Alliance for Bangladesh Worker ... Mark Chubb to serve as chief safety officer. In ... training in Bangladesh and guide remediation efforts in all ... will ensure that the Alliance continues to bring world-class ... Bangladesh garment workers,” said Alliance Independent Chair Ellen Tauscher. ...
(Date:3/2/2015)... California (PRWEB) March 02, 2015 Final ... of the TranStatic Volume 2 from Pixel Film Studios. , ... made exclusively for FCPX,” said Christina Austin, CEO of Pixel ... have in any Final Cut Pro X editors toolbox.” , ... to the next with media altering static scrambling effects from ...
(Date:3/1/2015)... 2015 As residents and business ... Michael Burns and Carita Weaver, believe in supporting ... with the Southlake Chamber of Commerce, Carroll Independent ... recently launched a website for Southlake mayoral candidate ... communications tool for Hill’s campaign, the website combines ...
(Date:3/1/2015)... Adults who are not legally married ... or universal policies can now use the QuotesPros.com portal ... insurance companies for single adults can now be researched ... . , The rate plans that nationwide agencies are ... a number of life protection policies. The term, universal ...
Breaking Medicine News(10 mins):Health News:Regulatory Compliance Associates® Inc. Welcomes Seyed Khorashahi as Chief Operating Officer 2Health News:Alliance for Bangladesh Worker Safety Names New Chief Safety Officer 2Health News:Pixel Film Studios released the TranStatic Volume 2 plugin for Final Cut Pro X today 2Health News:Website Launched for Southlake, Texas Mayoral Candidate Laura Hill 2Health News:Best Life Insurance Companies for Single Adults Now Searchable at Insurance Website 2
... , WEDNESDAY, Nov. 3 (HealthDay News) -- Undamaged areas ... of the brain called the prefrontal cortex, which is important ... examined brain activity in patients with damage to the prefrontal ... a control group of patients with no brain damage. Both ...
... 3 (HealthDay News) -- Anger can be a potent motivator ... study finds. While people generally regard anger as a ... of the brain that is associated with many positive emotions. ... after something, explained the researchers at Utrecht University in the ...
... Memory: Why Some Birthdays Are Harder to Remember Than ... Shigehiro Oishi People may have a better memory ... recalling their friends, birthdays tended to remember birthdays that ... farther away from their own birthday. In a separate ...
... Reporter , TUESDAY, Nov. 2 (HealthDay News) -- Only one in ... asthma symptoms in kids, a new study found. What,s ... symptom, according to the study, which was to be presented Nov. ... Physicians, in Vancouver, Canada. "We found that about 35 ...
... 2, 2010The Allen Institute for Brain Science ( www.alleninstitute.org ... includes new data and tools for exploring genes at ... and enhancing the Allen Human Brain Atlas, the Allen ... Glioblastoma Atlas Project and the NIMH Transcriptional Atlas of ...
... HealthDay Reporter , TUESDAY, Nov. 2 (HealthDay News) -- ... onto you. Researchers report that they,ve used brain scans ... trying to manipulate others into believing something that,s not true. ... hint at how complicated bluffing is compared to, say, simply ...
Cached Medicine News:Health News:Brain Can Compensate for Cognitive Damage 2Health News:Could Anger Make People Want Things More? 2Health News:New research from Psychological Science 2Health News:New research from Psychological Science 3Health News:New research from Psychological Science 4Health News:Many Coaches Unprepared for Student-Athletes' Asthma 2Health News:Many Coaches Unprepared for Student-Athletes' Asthma 3Health News:20th public data release by Allen Institute for Brain Science 2Health News:20th public data release by Allen Institute for Brain Science 3Health News:Study Unmasks the Biology of Bluffing 2