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Northwestern Medicine Researchers Investigate New Stent Technology to Treat Coronary Artery Disease
Date:8/16/2013

CHICAGO, Aug. 16, 2013 /PRNewswire-USNewswire/ -- Northwestern's Bluhm Cardiovascular Institute recently enrolled its first subject in ABSORB III, a clinical trial to study a "disappearing" heart device for the treatment of coronary artery disease (CAD). The investigational device, called the Absorb™ Bioresorbable Vascular Scaffold (BVS), made by healthcare company Abbott, is a small mesh tube designed to perform like a metallic stent by opening a blocked coronary artery and restoring blood flow to the heart. Unlike a traditional stent, which remains in the body permanently, the Absorb BVS is a temporary structure that dissolves over time.[i]

ABSORB III is the first U.S. clinical trial to evaluate the Absorb BVS System's potential benefits in comparison to a traditional drug eluting stent in patients with coronary artery disease (CAD). Researchers at the Bluhm Cardiovascular Institute are the first in Chicago to enroll subjects in the trial. 

"Coronary artery disease is the most common heart disease and a leading cause of death in both men and women," said Mark J. Ricciardi, M.D., medical director for the Northwestern Memorial Hospital's Center for Coronary Disease at the Bluhm Cardiovascular Institute and Northwestern's principal investigator for ABSORB III. "For these patients, the supply of blood and oxygen to the heart is blocked by a buildup of plaque in the walls of the coronary arteries. When enough blood doesn't reach the heart, patients experience symptoms including chest pain and shortness of breath."    

For more than three decades, physicians have treated coronary artery disease with balloon angioplasty and placement of stents. For more severe cases of CAD, coronary artery bypass surgery is sometimes necessary. A stent is a small, mesh coil that is either metal or coated with medications that help the artery remain open; these are known as drug eluting stents. The stent serves to help keep the artery open and decrease the chance of future blockages.

"Since the 1980s, these technologies have allowed many patients to avoid open heart surgery," said Ricciardi, who is also director of interventional cardiology at Northwestern Memorial and an associate professor at Northwestern University Feinberg School of Medicine. "While we've had great success with the current technology, once a stent is placed, it remains in the body forever. However, the stent support is really only needed for several months."

Absorb BVS is made of polylactide, a naturally dissolvable material that is commonly used in medical implants such as dissolving sutures. The device works by opening a clogged vessel and restoring blood flow to the heart similar to a drug eluting metallic stent, the current standard of care. Then unlike a permanent metallic stent, the Absorb BVS dissolves completely into the blood vessel, leaving behind only two pairs of tiny metallic markers which enable a physician to see where the device had been placed.  

With this study, researchers are seeking to understand the safety and effectiveness of the Absorb BVS in comparison to a traditional metallic stent.  The ABSORB III clinical trial will enroll approximately 2,250 subjects, the majority in the United States.

To learn more about the ABSORB III trial, please call the Bluhm Cardiovascular Institute Clinical Trials Unit (CTU) at 312-926-0840 or email kjordan@nmh.org.  

For more information on Northwestern's Bluhm Cardiovascular Institute, visit www.heart.nmh.org. To schedule an appointment, please call 312-NM-HEART (664-3278).

About Northwestern Memorial HealthCare
Northwestern Memorial HealthCare is the parent corporation of Chicago's Northwestern Memorial Hospital, an 894-bed academic medical center hospital and Northwestern Lake Forest Hospital, a 201-bed community hospital located in Lake Forest, Illinois. 

About Northwestern Memorial Hospital
Northwestern Memorial is one of the country's premier academic medical center hospitals and is the primary teaching hospital of the Northwestern University Feinberg School of Medicine.  Along with its Prentice Women's Hospital and Stone Institute of Psychiatry, the hospital has 1,705 affiliated physicians and 6,769 employees.  Northwestern Memorial is recognized for providing exemplary patient care and state-of-the art advancements in the areas of cardiovascular care; women's health; oncology; neurology and neurosurgery; solid organ and soft tissue transplants and orthopaedics.

Northwestern Memorial has nursing Magnet Status, the nation's highest recognition for patient care and nursing excellence. Northwestern Memorial ranks 6th in the nation in the U.S. News & World Report 2013-14 Honor Roll of America's Best Hospitals. The hospital is recognized in 14 of 16 clinical specialties rated by U.S. News and is No. 1 in Illinois and Chicago in U.S. News' 2013-14 state and metro rankings, respectively. For 13 years running, Northwestern Memorial has been rated among the "100 Best Companies for Working Mothers" guide by Working Mother magazine. The hospital is a recipient of the prestigious National Quality Health Care Award and has been chosen by Chicagoans as the Consumer Choice according to the National Research Corporation's annual survey for 13 years. 

[i] Absorb dissolves except for two pairs of tiny metallic markers, which help guide placement and remain in the artery to enable a physician to see where the device was placed.


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