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Northwest Biotherapeutics Receives Approval of US Patent for Cost Saving Automation of High-Concentration DCVax(R) Manufacturing
Date:12/4/2009

BETHESDA, Md., Dec. 4 /PRNewswire-FirstCall/ -- Northwest Biotherapeutics, Inc. ("NWBT" or the "Company") (OTC Bulletin Board: NWBO) announced today that the US Patent and Trademark Office has allowed its patent application on a system for automation of the initial stages of the manufacture of the Company's DCVax® therapeutic cancer vaccines. These initial manufacturing stages are key to the very high concentration of dendritic cells (which are the critical ingredient) in the finished DCVax® vaccine.

The current first generation (non-automated) manufacturing is highly precise, and achieves a concentration of at least 80% or more dendritic cells in the vaccines. (In contrast, various immune therapy products being developed by other parties contain much lower levels of active ingredient.) The automation system covered by the US patent maintains NWBT's very high levels of dendritic cells, while also enabling major reductions in costs and scale-up to handle large numbers of patients.

The essential active component in the DCVax® vaccine is the patient's own master immune cells, called "dendritic cells." The dendritic cells are responsible for mobilizing the entire immune system, and its many players (including T cells, B cells and the antibodies they produce, natural killer cells and others). The dendritic cells are obtained through a blood draw from the patient, with the desired cells carefully separated from the many other types of cells in the patient's blood. The more rigorously and precisely the dendritic cells are isolated, the higher the concentration of this active ingredient in the vaccine.

The automated system developed by NWBT maintains this very high level of precision and purity of dendritic cells in DCVax®. After years of development work, the system is able to consistently and reliably separate the desired cells from the many other kinds of cells in a patient's blood, despi
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SOURCE Northwest Biotherapeutics, Inc.
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