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Northwest Biotherapeutics Conducting Ovarian Cancer Clinical Trial With DCVax(R)-L at University of Pennsylvania
Date:12/27/2007

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About the Center for Research on Early Detection and Cure of Ovarian Cancer at the University of Pennsylvania

The Center for Research on Early Detection and Cure of Ovarian Cancer, directed by Dr. George Coukos, is a newly founded Research Center at the University of Pennsylvania. The Center comprises several full time translational and clinical scientists whose focus is to identify new detection methods, develop new therapies, and ultimately prolong and improve the quality of life for women with ovarian cancer.

Recent discoveries at the Center include the beneficial impact of immune response in advanced ovarian cancer; the contribution of inflammatory cells to the tumor vasculature; the role of tumor vasculature and tumor microenvironment in controlling the outcome of antitumor immune response and immune therapy; the identification of novel proteins expressed in ovarian cancer vasculature that can be targeted for early detection and therapy; and the identification of several gene alterations in ovarian cancer including miRNA genes.

The clinical research activities of the Center focus on developing individualized therapy approaches to patients with ovarian cancer, combining surgery and conventional therapy with novel immune therapies. A number of novel immune cellular therapeutic tools are under development in collaboration with the Cell and Vaccine Production Facility at the Abramson Cancer Center, directed by Drs. Carl June and Bruce Levine.

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Statements made in this news release that are not historical facts are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as "expects," "believes," "intends," and similar expressions are intended to identify forward-looking statements. Actual results may differ materially from those project
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SOURCE Northwest Biotherapeutics, Inc.
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