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Northwest Biotherapeutics Conducting Ovarian Cancer Clinical Trial With DCVax(R)-L at University of Pennsylvania
Date:12/27/2007

a very significant event for patients at the University of Pennsylvania and nationwide who are diagnosed with ovarian cancer. We are excited to work with Northwest Biotherapeutics on this cutting edge clinical trial, and to test the DCVax(R) platform on an additional cancer that carries a poor prognosis."

Dr. Carl June, the Penn sponsor on the trial, stated, "the combination of DCVax(R)-L for ovarian cancer with adoptive immunotherapy using T cells primed by DCVax(R)-L is an innovative approach that deserves testing in clinical trials."

"We are very pleased to add Ovarian cancer to the DCVax(R) platform, and to have Dr. George Coukos and Dr. Carl June lead this effort as the principal investigators for this clinical trial," stated Alton Boynton, President and Chief Executive Officer of Northwest Biotherapeutics. "Drs. Coukos and June are world renowned experts in immunotherapy and in ovarian cancer. They are playing a major role in the pioneering of novel cancer treatment strategies -- particularly by combining multiple different therapeutic approaches."

Ovarian cancer is the fourth leading cause of cancer death among women in the U.S. Approximately 22,400 new cases were diagnosed in the U.S. in 2006, and about 15,300 deaths occurred. In the majority of ovarian cancer cases, the disease has already reached late stage, and spread beyond the ovaries, before it is detected and diagnosed. After initial surgical removal of tumors, and treatment with currently available drugs, the median time to disease recurrence is 18 to 20 months. Recurrent disease is considered incurable and usually results in death, even with aggressive chemotherapy treatments. Accordingly, there is a major unmet medical need for new and more effective treatments for ovarian cancer -- especially recurrent ovarian cancer.

The DCVax(R) platform uses a patient's own tumor, surgically removed as part of the standard of care, to prepare a mix of their personal cancer biomarkers
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SOURCE Northwest Biotherapeutics, Inc.
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