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Northwest Biotherapeutics Conducting Ovarian Cancer Clinical Trial With DCVax(R)-L at University of Pennsylvania
Date:12/27/2007

First Patients Enrolled and Being Treated

BETHESDA, Md., Dec. 27 /PRNewswire-FirstCall/ -- Northwest Biotherapeutics, Inc. (OTC Bulletin Board: NWBO) (AIM: NWBT; NWBS) ("NWBT") today announced that a Phase I/II clinical trial in at least 30 patients, using DCVax(R)-L for recurrent ovarian cancer, has begun at The University of Pennsylvania Center for Research on Early Detection and Cure of Ovarian Cancer and the Abramson Cancer Center. The first patients have been enrolled and have undergone initial treatment steps in preparation for receiving DCVax(R)-L. The trial involves two sequential studies, and comprises an innovative combination of multiple treatment modalities. DCVax(R)-L forms the cornerstone of the treatment regimen, and is complemented by administration of low doses of certain existing approved drugs to help improve the immune system environment, as well as by adoptive transfer of patients' DCVax(R)-L primed T cells. The principal investigators for the trial are Dr. George Coukos and Dr. Sarah Kim, and the Penn Investigational New Drug ("IND") sponsor is Dr. Carl June. The funding is being provided by the Ovarian Cancer Vaccine Initiative. (See below for more information about this Initiative.)

DCVax(R)-L is a personalized immunotherapy for cancer, which is made from a patient's own dendritic cells (the master cells which initiate and manage the overall immune system response to a disease), and the "antigens" (biomarkers) from the patient's own tumor tissue which has been surgically removed as part of the standard of care. Such immunotherapy is sometimes referred to as a "therapeutic vaccine," as it is designed not to prevent cancer but to treat patients who already have cancer.

In the first study being conducted by NWBT and Penn, patients will first undergo standard surgery to reduce their tumor burden. Patients will then receive limited doses of two existing drugs to improve the immune system environment and mod
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SOURCE Northwest Biotherapeutics, Inc.
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