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Norditropin(R) Approved for Treatment of Children with Short Stature Associated with Turner Syndrome
Date:9/21/2007

with Turner syndrome show for the first time that a higher dose Norditropin treatment regimen results in growth to a height that is considered normal compared to the general population. This higher dose option gives physicians more dosing flexibility and a greater chance of successfully treating short stature."

About Turner Syndrome

Turner syndrome is a rare chromosomal disorder of females characterized by short stature and the lack of sexual development at puberty. Among affected females, physical features may include a short neck with a webbed appearance, heart defects, kidney abnormalities and various other malformations. Several medical problems occur more frequently in individuals with Turner syndrome than in the general population, including a heightened incidence of osteoporosis, cardiac malfunction diabetes and an increased risk of ear and hearing disorders. However, there is variability in the degree to which girls with Turner syndrome are affected by any of its manifestations.

Clinical Features and Complications

Many characteristic features are associated with Turner syndrome. Their presence and severity vary greatly from individual to individual and can include

-- Narrow, high-arched palate (roof of the mouth)

-- Misshapen ears and other ear disorders

-- Low hairline

-- Webbed neck

-- Broad chest

-- Scoliosis (curvature of the spine)

-- Cubitus valgus (arms that curve out slightly at the elbows)

-- Heart Defects

About Norditropin

Norditropin(R) (somatropin [rDNA origin] injection) is indicated for the treatment of children with short stature associated with Turner syndrome, the treatment of children with short stature associated with Noonan syndrome, and treatment of children with growth failure due to inadequate secretion of endogenous growth hormone and for replacement of endogenous growth hormone in adults with growth hormone deficiency (GHD) who meet either of the fol
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SOURCE Novo Nordisk
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