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NicOx and Ferrer Present Promising Clinical and Preclinical Results in Dermatology
Date:10/2/2007

allel, NicOx and Ferrer jointly presented a series of preclinical results from a novel, high potency, nitric oxide-donating anti-inflammatory compound at the congress, which showed a broader anti-inflammatory activity than commonly used treatments for skin disorders. These results were obtained in a validated preclinical model of skin disorders by following selected biological markers involved in inflammatory pathways (namely pro-inflammatory mediators such as PGE2, cytokines and TNF-alpha). Scientists have proposed a role for nitric oxide in a number of biological processes in the skin.

Antonio Guglietta, Head of Research and Development at Ferrer, commented: "Nitric oxide is thought to play an important role in the physiology of the skin and these new preclinical results suggest nitric oxide-donating anti- inflammatory agents could have improved efficacy over existing treatments. We believe this collaboration with NicOx can lead to the successful development of a more effective and safer treatment for skin disorders."

NOTE: NicOx and Ferrer aim to develop an improved product to treat a range of skin disorders, including Atopic Dermatitis, Psoriasis and Seborrheic Dermatitis, which affect millions of people each year. The severity of these

conditions can vary widely and in the worst cases they can be painful, increase the risk of infection and cause social isolation due to appearance.

NicOx (Bloomberg: COX:FP, Reuters: NCOX.PA) is a product-driven biopharmaceutical company dedicated to the development of nitric oxide- donating drugs to meet unmet medical needs. NicOx is targeting the therapeutic areas of inflammation and cardio-metabolic disease. Resources are focused on two lead compounds, naproxcinod (formerly HCT 3012); in phase 3 development for the treatment of signs and symptoms of osteoarthritis, and NCX 4016, in phase 2 for type 2 diabetes.

NicOx has strategic partnerships with some of the world's leading pharmaceutical compani
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SOURCE NicOx S.A.
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