NicOx and Ferrer Present Promising Clinical and Preclinical Results in D...( SOPHIA ANTIPOLIS France Oct. 2 /-...),Health

SOPHIA ANTIPOLIS, France, Oct. 2 /PRNewswire-FirstCall/ -- NicOx S.A. (Eurolist: COX) today announced the presentation of promising clinical and preclinical results from its collaboration with Ferrer Grupo International at the 21st World Congress of Dermatology, in Buenos Aires, Argentina. These included phase 1 results for NCX 1022, a prototype compound, showing the potential for improved safety and tolerability and preclinical results for a novel, high potency, nitric oxide-donating anti-inflammatory suggesting it could have enhanced anti-inflammatory activity over current dermatology products.

Ennio Ongini, Vice President of Research at NicOx, declared: "We are delighted to present these very promising results with Ferrer at this prestigious scientific meeting. These results highlight the potential of our technology in dermatology and suggest our joint program with Ferrer has the potential to provide more effective drugs to treat chronic skin disorders, which represent an increasing burden on medical services. Furthermore, the clinical data on NCX 1022 suggest that nitric oxide donation may also improve the safety margin over current treatments. We will continue to work closely with Ferrer to bring our promising drug candidate into clinical trials."

NicOx and Ferrer initiated their development program focused on high potency, nitric oxide-donating anti-inflammatory agents, for the treatment of a range of skin disorders (see NOTE), following encouraging results from a phase 1 study for NCX 1022, a lower potency prototype (see top-line results in press release of April 29, 2004). This presentation at the World Congress of Dermatology was the first time these results were presented at a scientific meeting. The results showed that the application of NCX 1022 ointment did not induce skin blanching with there being statistically significantly less skin blanching with NCX 1022 compared with three commonly used marketed products (p<0.001).

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