Navigation Links
NicOx' Naproxcinod ABPM Data Presented at American Heart Association
Date:11/7/2007

hieve statistical significance for DBP (p=0.007).

Blood pressure data were collected in the first phase 3 trial for naproxcinod (the 301 study) using Office Blood Pressure Measurements (OBPM) up to 13 weeks (see NOTE 2). The top-line results of this trial revealed a sustained reduction in blood pressure for naproxcinod, compared to baseline and naproxen. Additional results from this phase 3 trial are due to be presented on November 10, 2007, at the 71st annual meeting of the American College of Rheumatology.

"This ABPM trial was the first clinical study focusing specifically on naproxcinod's 24-hour blood pressure profile and its results reveal a clear difference compared to naproxen, which is one of the best-known cardiovascular NSAIDs," said Raymond Townsend, Professor of Medicine at the University of Pennsylvania, Philadelphia, who advised NicOx on the ABPM study. "The medical community recognizes the importance of blood pressure control in reducing the rate of serious cardiovascular events in elderly patients. These data add to the promising blood pressure results obtained by OBPM in the first 13-week phase 3 study and, if supported by the results of the ongoing 302 and 303 phase 3 studies, should contribute to naproxcinod becoming a valuable alternative to selective and non-selective NSAIDs for treating the signs and symptoms of osteoarthritis."

The presentation showed naproxcinod was well tolerated during the study. The number of subjects with at least one treatment related adverse event was low and evenly spread between naproxcinod and naproxen. There were no adverse events suggesting clinically significant hypotensive effects in either group.

Details of study design and ABPM monitoring

The trial was an 8-week, double-blind, randomized, cross-over study in which 131 male and female healthy volunteers were enrolled at 15 US clinical sites to receive either naproxcinod 750 mg bid, followed by naproxen 500 mg bid for 2 weeks, or the
'/>"/>

SOURCE NicOx S.A.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. NicOx Reports TOPIGEN to Advance TPI-1020 Into Phase 2 for COPD Following Promising Clinical Results
2. NicOx and Ferrer Present Promising Clinical and Preclinical Results in Dermatology
3. Quark Pharmaceuticals, Inc. Presented Positive Preclinical Results of Systemic RNAi Compound for Acute Renal Failure (ARF)
4. Pre-clinical Data on Recent Advances with HIV VLP Vaccine Presented at AIDS Vaccine 07 Conference
5. New Study Presented at WorldSleep 2007 Demonstrates Ramelteon Has Sustained Efficacy Over Six Months in Adults With Chronic Insomnia
6. Genasense(R) Data in Melanoma to be Presented in Opening Session at First Worldwide Melanoma Center Meeting of the European Association of Dermato-Oncology
7. Ozarelix Phase 2 Data Presented at 29th Congress of the Societe Internationale dUrologie
8. GeoVax Successful HIV/AIDS Vaccine Trial Data Presented at AIDS Vaccine 2007 Conference
9. Study Results for Aclidinium Bromide, a Novel Anticholinergic, Presented at European Respiratory Society Annual Congress
10. Promising Data from Paratek Pharmaceuticals MAR Inhibitor Program Presented in Late Breaker Session at the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy
11. New Phase III Data Presented for Once Monthly Dosing Regimen of Risedronate to Treat Postmenopausal Osteoporosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... NEW YORK , Sept. 17, 2014 /PRNewswire/ ... Summary GlobalData,s new report, "Germany ... market data on the Germany Gynecological Devices market. ... dollars, volume (in units) and average prices (in ... Devices (Transcervical Sterilization Devices (Micro-inserts) and Mechanical Sterilization ...
(Date:9/17/2014)... SANTA MONICA, Calif. , Sept. 17, 2014 /PRNewswire-USNewswire/ ... who is at the White House today for National ... Proposition 46 that consumer advocates released today. Consumer advocates ... woman who spoke out after losing her ... later discovering that the doctor had a history of ...
(Date:9/17/2014)... , Sept. 17, 2014  Decision ... colitis (CD/UC) patients eligible for biologic therapy, ... a biologic. Surveyed gastroenterologists cite patients, discomfort ... for low penetration rates, followed by cost-related ... UC patients receiving biologics, Janssen Biotech,s Remicade ...
Breaking Medicine Technology:Germany Gynecological Devices Market Outlook to 2020 2Germany Gynecological Devices Market Outlook to 2020 3Doctor Recovering From 100-Pill-A-Day Addiction Stars In New Ad Supporting Prop 46; Appears At White House for National Recovery Month, Says Consumer Watchdog Campaign 2Doctor Recovering From 100-Pill-A-Day Addiction Stars In New Ad Supporting Prop 46; Appears At White House for National Recovery Month, Says Consumer Watchdog Campaign 3The Majority of Surveyed Gastroenterologists Agree that Biologics Should be Prescribed to More Patients in the Crohn's Disease and Ulcerative Colitis Treatment Paradigm 2The Majority of Surveyed Gastroenterologists Agree that Biologics Should be Prescribed to More Patients in the Crohn's Disease and Ulcerative Colitis Treatment Paradigm 3
... OncoSec Medical Incorporated (OTCBB:ONCS), which is developing ... to treat solid tumor cancers, today announced that ... and Lakeland Comprehensive Cancer Center in Lakeland, FL ... are screening patients for the Phase II metastatic ...
... International, Inc. (NASDAQ: BDSI ) announced that ... of further litigation in the patent infringement lawsuit previously ... that the case would be stayed pending resolution by ... proceedings and follows the recent rejection by the USPTO ...
Cached Medicine Technology:OncoSec Initiates Two Additional Clinical Sites for Phase II Metastatic Melanoma Trial 2OncoSec Initiates Two Additional Clinical Sites for Phase II Metastatic Melanoma Trial 3OncoSec Initiates Two Additional Clinical Sites for Phase II Metastatic Melanoma Trial 4Federal Court Grants Request by BioDelivery Sciences for Stay of MonoSol Litigation 2Federal Court Grants Request by BioDelivery Sciences for Stay of MonoSol Litigation 3
(Date:9/18/2014)... September 18, 2014 First Choice ... emergency rooms in the United States, named Douglas J. ... Missouri City-Lakes facility. , “We are pleased to ... medical director of our new Missouri City-Lakes facility,” said ... Choice Emergency Room. , Dr. Harrison received his ...
(Date:9/18/2014)... 9Lover.com, an internationally well-known designer and leader in the ... for its maternity wedding outfits. Now, all the company’s ... wedding dresses on its website. , 9Lover.com ... The company’s development manager believes the cheap maternity wedding ... current special offer will last until September 29, 2014. ...
(Date:9/17/2014)... ball gown is the most formal female attire for ... the floor, made of luxurious fabric, delicately and exotically ... and retailer, has delightedly unveiled its new series of ... at discounted rates. , Most versions are cut off ... worn with a stole (a formal shawl in expensive ...
(Date:9/17/2014)... D.C. (PRWEB) September 18, 2014 The ... in the Match , a comprehensive analysis of the ... to a preferred specialty. The new edition is ... data by specialty for U.S. allopathic medical school senior ... delighted to be able to provide this new edition ...
(Date:9/17/2014)... Creek, MI (PRWEB) September 17, 2014 ... , an open-ended drug and alcohol treatment program that ... them a solid foundation in recovery they can believe ... depression. , “About 20% of Americans who are afflicted ... both,” commented A Forever Recovery’s CEO Per Wickstrom ...
Breaking Medicine News(10 mins):Health News:First Choice Emergency Room Announces Dr. Douglas J. Harrison as Medical Director of Missouri City - Lakes, Texas Facility 2Health News:Discounted Maternity Wedding Dresses For 2014 Introduced By 9Lover.com 2Health News:Fecbek.com: Ladies Can Be Elegant Enough to Draw Everyone’s Attention by Wearing Trendy Ball Gowns 2Health News:Just Released: Charting Outcomes in the Match for the 2014 Main Residency Match® 2Health News:Just Released: Charting Outcomes in the Match for the 2014 Main Residency Match® 3Health News:Latest A Forever Recovery Blog Post Explores the Link Between Addiction and Depression 2Health News:Latest A Forever Recovery Blog Post Explores the Link Between Addiction and Depression 3
... BRAUNFELS, Texas, Feb. 5 The following,release was issued ... 59, car crash victim and ten-year resident at the,Eden ... Store EVP of Operations, Dan Gibbens, The SCOOTER ... Store Gift of Mobility Administrator, Betty Doeppenschmidt, of ...
... Outsources Billing, Accounts Receivable Services, BIRMINGHAM, ... Practice Services unit has completed an agreement ... Paramedical Services,one of the largest medical transport ... and software for billing and accounts,receivable management., ...
... Pa., Feb. 5 West Pharmaceutical,Services, Inc. (NYSE: ... Chairman and Chief Executive Officer, and William Federici, Chief,Financial ... Healthcare,Services Conference at 3:00 p.m. on February 11, 2008 ... corporate presentation document will be posted on the,investor link ...
... ... to LYFT, PALM SPRINGS, Calif., Feb. 5 ... its 12th Annual Winter,Symposium in Palm Springs, Calif. The meeting, which will ... using,high-risk donors, will open with a discussion of the proposed organ,allocation system ...
... 5 /PRNewswire-FirstCall/ - CRH Medical Corporation,(CRM:TSX-V) announced today ... had,13,461 patient visits at its Centers for Colorectal ... period in 2006., Commenting on this achievement, ... 2007, we demonstrated the strong demand for the ...
... 10:00am EST Today, LENEXA, Kan., Feb. 5 ... of ClosedLoop(TM) clinical systems,for blood and medication management, reported ... of $8,659,000 compared to $11,262,000 in the,comparable quarter in ... or a loss of four cents per fully diluted ...
Cached Medicine News:Health News:Regional Paramedical Services and DST Health Solutions Complete Business Process Outsourcing Agreement 2Health News:West Pharmaceutical Services to Present at the 2008 UBS Global Healthcare Services Conference 2Health News:AST to Address New Concept in Organ Allocation at March 13-16 Winter Symposium 2Health News:CRH Medical Corporation announces substantial increase in patient visits 2Health News:Mediware Reports Second Quarter Fiscal 2008 Results 2Health News:Mediware Reports Second Quarter Fiscal 2008 Results 3Health News:Mediware Reports Second Quarter Fiscal 2008 Results 4