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NicOx Completes Enrollment of Two Ambulatory Blood Pressure Measurement (ABPM) Studies for Naproxcinod in Hypertensive OA Patients
Date:7/22/2008

naproxen 250 mg bid, naproxen 500 mg bid or ibuprofen 600 mg tid (three times daily).

The data from the 111 and 112 studies will complement the results of a 2-week ABPM study with naproxcinod compared to naproxen in hypertensive volunteers (the 104 study), which were presented at the American Heart Association (AHA) in November 2007. They will also complement the Office Blood Pressure Measurements (OBPMs) being collected in each of the pivotal phase 3 OA studies (including the completed 301 study and the ongoing 302 and 303 studies).

Maarten Beekman, Vice President of Clinical Development and Medical Affairs at NicOx commented: "We are very pleased to have fully enrolled these two clinical pharmacology studies and we look forward to their results in the fourth quarter of this year. We believe the timely achievement of this milestone is a testament to the strength of the clinical team we have assembled at NicOx and also reflects the interest of clinical centers and patients in naproxcinod."

NicOx (Bloomberg: COX:FP, Reuters: NCOX.PA) a product-driven biopharmaceutical company dedicated to the development and future commercialization of investigational drugs for unmet medical needs. NicOx is applying its proprietary nitric oxide-donating technology to develop an internal portfolio of New Chemical Entities (NCEs) in the therapeutic areas of inflammatory and cardio-metabolic disease.

Resources are focused on the development of naproxcinod, a proprietary NCE and the first compound in the Cyclooxygenase-Inhibiting Nitric Oxide-Donating (CINOD) class of anti-inflammatory agents, which is in phase 3 clinical studies for the treatment of the signs and symptoms of osteoarthritis, with final phase 3 results anticipated in 2008.

Beyond naproxcinod, NicOx has a pipeline containing multiple nitric oxide-donating NCEs, which are in development internally and with partners, including Pfizer Inc and Merck & Co., Inc., for the treatment of prevalen
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4. NicOx Naproxcinod Phase 3 Results Presented at American College of Rheumatology
5. NicOx Announces TOPIGEN Initiates Phase 2 Proof of Concept Study in COPD for TPI 1020
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9. NicOx Announces Initiation of First Phase 1 Study of Investigational Nitric Oxide-Donating Agent in Hypertensive Patients by Merck & Co., Inc.
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