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NicOx Announces Initiation of First Phase 1 Study of Investigational Nitric Oxide-Donating Agent in Hypertensive Patients by Merck & Co., Inc.
Date:5/13/2008

To date, NicOx has received euro 19.2 million from Merck under this agreement. NicOx also stands to receive potential additional milestone payments of euro 269 million and industry standard royalties on the sales of products which result from the agreement. Furthermore, NicOx has the option to co-promote resulting products, on a fee-for-detail basis, to specialist physicians in the United States and certain major European countries.

"We are delighted that less than one year after the first drug candidate entered human testing, we now have three drug candidates identified and that the first of these has started patient dosing," said Michele Garufi, Chairman and CEO of NicOx. "We look forward to continued rapid progress in our collaboration with Merck and to the future introduction of a new anti-hypertensive class on the market."

NicOx (Bloomberg: COX:FP, Reuters: NCOX.PA) is a product-driven biopharmaceutical company dedicated to the development and future commercialization of investigational drugs for unmet medical needs. NicOx is applying its proprietary nitric oxide-donating technology to develop an internal portfolio of NCEs in the therapeutic areas of inflammatory and cardio-metabolic disease.

Resources are focused on the development of naproxcinod, a proprietary NCE and the first compound in the Cyclooxygenase Inhibiting Nitric Oxide-Donating (CINOD) class of anti-inflammatory agents, which is in phase 3 clinical studies for the treatment of the signs and symptoms of osteoarthritis, with final phase 3 results anticipated in 2008.

Beyond naproxcinod, NicOx has a pipeline containing multiple nitric oxide-donating NCEs, which are in development internally and with partners, including Pfizer Inc and Merck & Co., Inc., for the treatment of prevalent and underserved diseases, such as atherosclerosis, hypertension, glaucoma and Chronic Obstructive Pulmonary Disease (COPD).

NicOx S.A. is headquartered in France and is listed on the Eu
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SOURCE NicOx S.A.
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