Navigation Links
NicOx Announces Favorable Blood Pressure Data for Naproxcinod in a Large ABPM Study
Date:11/4/2008

SOPHIA ANTIPOLIS, France, November 4 /PRNewswire-FirstCall/ -- NicOx S.A. (Euronext Paris: COX) today announced positive top-line results from a 118 patient Ambulatory Blood Pressure Monitoring (ABPM) trial (the 111 study), which compared the 24-hour blood pressure profile of escalating doses of naproxcinod and naproxen in osteoarthritis (OA) patients with controlled hypertension. The primary ABPM parameter was the mean 24-hour ambulatory systolic blood pressure (SBP) measured by ABPM over the whole study period and naproxcinod showed a statistically significant decrease in SBP of 3.8 mmHg (p=0.011) compared to naproxen. Furthermore, in contrast to naproxen, naproxcinod reduced the mean 24-hour SBP and diastolic blood pressure (DBP) from baseline at every dose comparison. Good safety and tolerability were shown by all naproxcinod doses. NicOx plans to provide further details of the results at a leading cardiology conference in 2009.

Naproxcinod is the first investigational drug in the new Cyclooxygenase-Inhibiting Nitric Oxide-Donator (CINOD) class of anti-inflammatory agents, which is nearing the end of phase 3 clinical development for the treatment of the signs and symptoms of osteoarthritis, with the submission of a New Drug Application (NDA) with the US Food and Drug Administration (FDA) projected for mid-2009. NicOx expects to have the results of a second large ABPM study in patients with hypertension and OA (112) before the end of 2008, in addition to the results of the remaining pivotal phase 3 trial in hip OA (303).

COX-2 inhibitors and traditional non-steroidal anti-inflammatory drugs (NSAIDs), such as naproxen and ibuprofen, are widely used as symptomatic treatments for OA. However, they can cause new episodes of high blood pressure and destabilize previously controlled hypertensive patients, which is a particular concern in the OA population where approximately 50% of patients are estimated to be hypertensive.

"These impressive
'/>"/>

SOURCE NicOx
Copyright©2008 PR Newswire.
All rights reserved

1082

GOOD

Page: 1 2 3 4

Related medicine technology :

1. NicOx Announces Second Naproxcinod Pivotal Phase 3 Study (302) Meets Efficacy Primary Endpoints and Supports Non-Detrimental Blood Pressure Effect
2. NicOx Announces Top-Line Results From Naproxcinod 52-Week 301 Safety Extension
3. NicOx Completes Enrollment of Two Ambulatory Blood Pressure Measurement (ABPM) Studies for Naproxcinod in Hypertensive OA Patients
4. NicOx Announces Blood Pressure Analysis From 301 Phase 3 Study for Naproxcinod at EULAR
5. NicOx Completes Patient Enrollment in Third Naproxcinod Pivotal Phase 3 Study
6. NicOx Announces Initiation of First Phase 1 Study of Investigational Nitric Oxide-Donating Agent in Hypertensive Patients by Merck & Co., Inc.
7. Financial Results for Full Year 2007: NicOx Significantly Advances Clinical Programs
8. NicOx Announces Pfizer Initiates Phase 2 Clinical Development for PF-03187207 in Japan
9. NicOx Completes Enrollment in Second Pivotal Phase 3 Study for Naproxcinod and Provides Development Update
10. NicOx Announces TOPIGEN Initiates Phase 2 Proof of Concept Study in COPD for TPI 1020
11. NicOx Naproxcinod Phase 3 Results Presented at American College of Rheumatology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... , Aug. 22, 2014  Medical Science Liaisons serve ... leaders in the healthcare sector. As the impact of ... is changing how Medical Science Liaisons (MSLs) interact with ... are using the tablet to not only share important ... better coordinate thought leader interactions across geographies and therapeutic ...
(Date:8/22/2014)... Ireland , August 22, 2014 /PRNewswire/ ... and Markets ( http://www.researchandmarkets.com/research/x34qgv/global_laboratory ) has announced the ... Market 2014-2018"  report to their offering.  ... balance is an essential instrument for any ... the precise weighing of materials. It can ...
(Date:8/22/2014)... DUBLIN , August 22, 2014 /PRNewswire/ ... ) has announced the addition of the  ... to their offering.       (Logo: ... room with a sterile environment in a ... It is equipped with technically advanced equipment, ...
Breaking Medicine Technology:iPads Enhancing Medical Science Liaison Interactions with Thought Leaders, New Study Shows 2Global Laboratory Electronic Balance Market 2014-2018: Key Vendors are A&D Company, Mettler-Toledo, Sartorius and Thermo Fisher 2Global Operating Room Equipment Market 2014-2018: Key Vendors are Getinge, STERIS, Stykron and TRUMPF Medical Systems 2
... new visual evoked potential method has been developed to ... and/or neurological conditions. The research team of Kenneth Ciuffreda, ... SUNY State College of Optometry, Department of Vision Sciences ... of Different Stimulus Configurations on the Visually Evoked Potential ...
... 2, 2011 The U.S. Food and Drug Administration, ... two reports detailing the results of pilot programs focused ... that drug quality and safety can be enhanced globally. ... The report on the Good Clinical Practice (GCP) ...
Cached Medicine Technology:A New, Objective Way to Assess Visual Fields: Visual Evoked Potentials 2A New, Objective Way to Assess Visual Fields: Visual Evoked Potentials 3FDA, International Counterparts Report Progress on Drug Inspection Collaboration 2FDA, International Counterparts Report Progress on Drug Inspection Collaboration 3
(Date:8/22/2014)... Las Vegas, NV (PRWEB) August 22, 2014 ... affordable email marketing services that currently helps more ... marketing efforts has caught the attention of Shane Michaels, ... a still a crucial element for any online marketing ... media replacing email in the marketing world,” reports Michaels. ...
(Date:8/22/2014)... Buying a policy for different life insurance products can be ... types by insurers in the U.S. The Quotes Pros company ... public using its sortable tool at http://quotespros.com/life-insurance.html . ... expected to promote the discounts and special offerings for policies ... system is designed to help an adult locate a policy ...
(Date:8/22/2014)... The regional economy is about to ... on the grow again. The plant will invest ... to boost production of the popular Highlander midsize sport ... investment to $4 billion. This step allows Toyota to ... flexibility to adjust its product mix to meet changing ...
(Date:8/22/2014)... New York (PRWEB) August 22, 2014 ... power morcellators ( http://www.injurybeacon.com/power-morcellator/ ) in uterine surgeries ... several Massachusetts insurance companies have decided to limit ... from the Worcester Telegram, Blue Cross-Blue Shield of ... removal surgeries that involve morcellation as of September ...
(Date:8/22/2014)... protein 11 (BIM) deletion in advanced non-small cell ... free survival (PFS) in epidermal growth factor receptor ... Asian patients. Also, BIM deletion independently predicts overall ... BIM protein can activate the programmed cell death ... BIM deletion has been detected in 12.8% of ...
Breaking Medicine News(10 mins):Health News:AWeber: Review Exposes Affordable Provider of Opt-In Email Marketing Services 2Health News:Principal Life Insurance Policies Now Quoted for Adults at Insurance Website Online 2Health News:Toyota Indiana Adding 300 Jobs to Build More Highlanders 2Health News:As Power Morcellator Controversy Grows, Bernstein Liebhard LLP Comments on Massachusetts Insurers’ Plans to Limit Coverage of Uterine Morcellation 2Health News:As Power Morcellator Controversy Grows, Bernstein Liebhard LLP Comments on Massachusetts Insurers’ Plans to Limit Coverage of Uterine Morcellation 3Health News:As Power Morcellator Controversy Grows, Bernstein Liebhard LLP Comments on Massachusetts Insurers’ Plans to Limit Coverage of Uterine Morcellation 4Health News:Deletion predicts survival in advanced non-small cell lung cancer 2
... on CT scans, experts note, , , WEDNESDAY, Nov. 26 ... common injury seen in young children, U.S. doctors report ... surprising cause -- hair beads. , What,s worse, ... on diagnostic CT scans, the physicians say. , Study ...
... ) announced today that its Board of Directors increased the regular,quarterly ... quarter of,fiscal 2009. This increase represents an annual rate of ... paid on January 2, 2009 to,shareholders of record on December 12, ... Landauer is the leading provider ...
... Employee Benefits Offered in Four Employment Sectors , ... ... to tumble, U.S. workers are looking for help in managing their ... , ,A recent survey of employers conducted by the International ...
... enlarged, inflamed, or life threatening cancerous prostate glands. Men finally have ... reduce suffering, as recommended by hundreds of medical doctors and health ... ... Most men are expected to have some kind of prostate issue, ...
... Nov. 25 The LifeSpan rowing machine, made by PCE ... Excellence award in a review of best fitness equipment for ... awarded the top rated LifeSpan Rowing Machine a Seal of ... rowing machine was reviewed by a team of fitness experts. ...
... UnitedHealth HEROES offering grants of up to $1,000 to fund ... , WASHINGTON, Nov. 25 ... Youth Service of America (YSA) to launch UnitedHealth Heroes, a ... support teachers, service-learning coordinators and students in the health professions ...
Cached Medicine News:Health News:Hair Beads Spurring Head Trauma in Kids 2Health News:Hair Beads Spurring Head Trauma in Kids 3Health News:43% of Employers Offer Financial Education Programs for Their Employees 2Health News:43% of Employers Offer Financial Education Programs for Their Employees 3Health News:43% of Employers Offer Financial Education Programs for Their Employees 4Health News:ProstateCradle.com Launches the First “External Prostate Massager” by Enviromax, a Sensational Way to Help Millions of Men Have Healthier Prostate Glands 2Health News:LifeSpan Rowing Machine Wins Award in Best Fitness Equipment Review 2Health News:Youth Service America and UnitedHealth Group Offer 'HEROES' Grants to Fight Childhood Obesity 2Health News:Youth Service America and UnitedHealth Group Offer 'HEROES' Grants to Fight Childhood Obesity 3
... a highly featured laser doppler system ... perfusion from multiple tissue sites. This ... Digital Signal Processing (DSP) and laser ... yet simple to use, multi-channel monitor, ...
Transcranial vascular DWL doppler....
Transcranial vascular DWL doppler....
... Imexlab 3000DX bidirectional vascular testing system ... for the physician concerned with arterial ... designed and made by Nicolet Vascular, ... diagnostic systems chosen by thousands of ...
Medicine Products: