Navigation Links
Niacin Causes Serious Unexpected Side-effects, but no Worthwhile Benefits, for Patients who are at Increased Risk of Heart Attacks and Strokes
Date:3/9/2013

treatments (including effective statin-based cholesterol-lowering therapy) would produce worthwhile reductions in the risks of heart attacks, strokes or other cardiovascular outcomes.  Among those who took the ER niacin combination 13.2% suffered a heart attack, stroke or had an arterial procedure compared with 13.7% in those who took the dummy (placebo) tablets  ̶  a small but not clearly significant difference.

Side effects previously found with niacin, which were also seen in HPS2-THRIVE, included skin rashes, gastro-intestinal (stomach) problems, complications with the management of pre-existing diabetes and increased risk of developing diabetes. The newly identified side effects were infections and bleeding (particularly in the gut and brain), neither of which had been clearly demonstrated with niacin previously.

The results in HPS2-THRIVE are consistent with the results from other trials of ER niacin. For example, the AIM-HIGH trial of ER niacin alone (i.e. without the addition of laropiprant) in 3,400 high-risk patients was stopped prematurely after 3 years because no beneficial effects on heart attacks and strokes were seen. The known side effects of ER niacin were also seen in AIM-HIGH.  Further analyses of AIM-HIGH should be able to show if there are similar trends on bleeding and infections to those in HPS2-THRIVE.

The HPS2-THRIVE findings have resulted in the suspension by Merck & Co/MSD of the ER-niacin and laropiprant combination therapy from Europe and other countries where it had been approved for use. Although the combination therapy was not licensed in the US, regulatory authorities are now considering the implications of these results for the use of other forms of extended release niacin.

Principal Investigator Professor Jane Armitage , from Oxford University's CTSU, said: "The use of niacin for the prevention of cardiovascular events
'/>"/>

SOURCE CTSU Oxford University
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Leading Cardiology Experts Advice on Dietary Supplement Niacins: Make Informed Choices at the Shelf and Scan the Label for Nicotinic Acid
2. Arisaph Pharmaceuticals Reports Positive Results From Two Safety Clinical Trials For Its Niacin Analog (ARI-3037MO)
3. Leading Cardiologist Dispels the Myths about Dietary Supplement Niacin
4. First, do no harm: Study finds danger in standard treatment for a serious lung disease
5. Gateway Foundation Warns K2 is Bad News: K2 Poses Serious Health Risks
6. Dallas Car Wreck Lawyer Discusses Serious Consequences of Driving While Under the Influence of Drugs
7. The International Serious Adverse Event Consortium and UC San Diego To Collaborate On Research Into The Genetics Of Drug Induced Renal Injury
8. Da Vinci Robot May Cause Serious Complications for Patients Receiving Hysterectomies and Other Procedures, Reports Surgical News
9. IRIDEX Announces FDA 510(k) and CE Clearance of New Laser Delivery System for Fast, Non-invasive Treatment of Serious Retinal Diseases
10. Immunotech Laboratories (IMMB) Patented "IPF" Technology A Serious Contender In The Race For HIV & Cancer Cures
11. Lillys Team Solutions and Solutions for Wellness Resources for Serious Mental Illness Added to SAMHSAs Distinguished National Registry
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... the Netherlands , May 5, 2015 ... lower esophageal sphincter (LES) stimulation therapy for gastroesophageal ... and efficacy results. The results demonstrated an excellent ... regurgitation and the "gold-standard" esophageal acid exposure (measured ... of dependence on daily PPI medications. ...
(Date:5/5/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/9pthtm/home_healthcare ) has ... Market - Forecast to 2020" report to their ... to reach more than $300+ billion growing at a ... equipment market is expected to grow at a faster ... is gaining a tremendous attention over hospitals for the ...
(Date:5/5/2015)... Calif., May 5, 2015 Isis Pharmaceuticals, Inc. ... income of $4.0 million for the three months ended ... operating loss of $22.6 million for the same period ... to higher revenue from milestone payments earned from its ... a GAAP basis, Isis reported a loss from operations ...
Breaking Medicine Technology:Excellent three year results of EndoStim therapy for severe reflux disease presented at the SAGES Annual Meeting in Nashville. 2Excellent three year results of EndoStim therapy for severe reflux disease presented at the SAGES Annual Meeting in Nashville. 3Global Home Healthcare Global Market 2015 - Forecast to 2020 for the $300 Billion Market 2Isis Reports Financial Results and Highlights for First Quarter 2015 2Isis Reports Financial Results and Highlights for First Quarter 2015 3Isis Reports Financial Results and Highlights for First Quarter 2015 4Isis Reports Financial Results and Highlights for First Quarter 2015 5Isis Reports Financial Results and Highlights for First Quarter 2015 6Isis Reports Financial Results and Highlights for First Quarter 2015 7Isis Reports Financial Results and Highlights for First Quarter 2015 8Isis Reports Financial Results and Highlights for First Quarter 2015 9Isis Reports Financial Results and Highlights for First Quarter 2015 10Isis Reports Financial Results and Highlights for First Quarter 2015 11Isis Reports Financial Results and Highlights for First Quarter 2015 12Isis Reports Financial Results and Highlights for First Quarter 2015 13
(Date:5/6/2015)... Geoff Hanson is no stranger to success ... takes his first head coaching assignment at Western State Colorado ... diving coach, The Mountaineers finished sixth at the Rocky Mountain ... , Hanson was a four-year letter winner and two-time ... and a Pac-10 Conference finalist for four years. Hanson also ...
(Date:5/6/2015)... York, NY (PRWEB) May 06, 2015 ... producer in New York City, announced today that it ... Creative Awards for a presentation video produced on behalf ... award in the category of motion graphics. , The ... Professionals (AMCP), received over 6000 entries from 22 countries. ...
(Date:5/6/2015)... May 06, 2015 The joint venture ... first freestanding emergency room in Chandler on Friday, May ... General Hospital, which is also part of the Dignity ... grand opening, Dignity Health Arizona General Hospital Emergency Room ... of Commerce and donated $5,000 to Campo Verde High ...
(Date:5/6/2015)... May 06, 2015 The beverage industry ... drinks. Little Miracles organic tea and superfruit fusions stands ... ginseng and sweetened with agave, these delicious juice blends ... that seeks healthier ways to hydrate. , In collaboration ... invites people to raise a bottle of Lemongrass Tea ...
(Date:5/5/2015)... 06, 2015 Social Media Regulatory Affairs ... Media Your Most Powerful Marketing Tool and Get the ... http://www.fdanews.com/SocialMedia , Social media … Is it ... media’s reach. Patients are using it — learning about ... what they’ve discovered. , But, it can become a ...
Breaking Medicine News(10 mins):Health News:US Sports Camps and Nike Swim Camps Partner with Geoff Hanson to Offer Swim Camps at Western State Colorado Univeristy 2Health News:The SGNY Group Wins Platinum Hermes Creative Award 2Health News:Dignity Health and Adeptus Health Opened First Freestanding Emergency Room in Chandler, Arizona 2Health News:Dignity Health and Adeptus Health Opened First Freestanding Emergency Room in Chandler, Arizona 3Health News:Say Cheers to National Beverage Day with Little Miracles 2Health News:FDAnews Announces: Social Media Regulatory Affairs Summit, June 24-26, 2015 2Health News:FDAnews Announces: Social Media Regulatory Affairs Summit, June 24-26, 2015 3Health News:FDAnews Announces: Social Media Regulatory Affairs Summit, June 24-26, 2015 4
... The American Society of,Hematology (ASH), the world,s ... United States Congressmen and a,hematologist for promoting biomedical ... are given in conjunction with the Society,s,49th Annual ... and Edward Markey (D-MA) will both,receive ASH,s Award ...
... December 5, 2007 Researchers in Montreal and ... the HIV/HAART*-associated Lipodystrophy Syndrome. This syndrome is a ... infection. Dr. Julian Falutz, Director of the HIV ... (MUHC), and Dr. Steven Grinspoon, Director at the ...
... air pollution, especially diesel exhaust , , WEDNESDAY, Dec. 5 ... the health damage done by automotive air pollution, especially ... period of improving air quality in Switzerland, which started ... measurable benefits in lung function for adults as they ...
... Insurance,Holdings, Inc. (Nasdaq: EIHI ) ("EIHI," the "Company") ... $0.05 per share quarterly cash,dividend on its issued and ... shareholders of record at the close of business on,December ... Eastern Life and Health Insurance Company,("Eastern Life and Health"), ...
... COLLEGEVILLE, Pa., Dec. 5 Wyeth,Pharmaceuticals, a division ... that it,has been recognized for its leading scientific ... ceremony held in London,England on December 4. Wyeth ... Drug. The awards are given out by Scrip ...
... role, and the condition can be inherited from both parents, ... U.S. team has spotted nine genetic markers that can increase ... that the condition can be inherited in what geneticists call ... a person inherits identical copies of these markers from each ...
Cached Medicine News:Health News:ASH Honors Two Congressmen and NIDDK Director for their Public Service and Leadership in Hematology 2Health News:Major breakthrough toward the treatment of HIV/HAART-associated Lipodystrophy Syndrome 2Health News:Cleaner Air Leads to Healthier Lungs 2Health News:Cleaner Air Leads to Healthier Lungs 3Health News:Eastern Insurance Holdings, Inc. Announces Quarterly Dividend 2Health News:Eastern Insurance Holdings, Inc. Announces Quarterly Dividend 3Health News:Wyeth Receives Honors at the 2007 Scrip Awards 2Health News:Wyeth Receives Honors at the 2007 Scrip Awards 3Health News:Wyeth Receives Honors at the 2007 Scrip Awards 4Health News:Wyeth Receives Honors at the 2007 Scrip Awards 5Health News:Genes Yield More Clues to Schizophrenia 2
... Our ELISA products for autoimmune testing feature ... as well as specific reflex tests including ... Sm/RNP, SS-A (Ro), SS-B (La), Scl-70 and ... includes a full line of products for ...
... ELISA products for autoimmune testing feature single-well ... well as specific reflex tests including dsDNA, ... SS-A (Ro), SS-B (La), Scl-70 and Jo-1. ... a full line of products for Cardiolipins ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: