Navigation Links
Nexavar in Combination with Chemotherapy Improves Progression-Free Survival in Patients with Advanced Breast Cancer in Phase 2 Study
Date:5/18/2011

r are continuing to explore Nexavar's potential utility in breast cancer through a Phase 3 trial evaluating Nexavar in combination with capecitabine in advanced breast cancer in the RESILIENCE (Phase 3 TRial Comparing CapecitabinE in Combination with SorafenIb or PLacebo for Treatment of Locally Advanced or MetastatIc HER2–Negative Breast CancEr) trial."

The safety and tolerability profile of the combination was consistent with the previous experience. The most commonly reported treatment-emergent Grade 3/4 adverse events were hand-foot skin reaction (39 percent), neutropenia (21 percent) and stomatitis (10 percent).

Phase 2b Trial Design

This Phase 2b randomized, double-blind, placebo-controlled trial evaluated Nexavar in combination with chemotherapeutic agents, gemcitabine (1000 mg/m2) or capecitabine (1000 mg/m2) in 160 patients with locally advanced or metastatic HER-2 negative breast cancer who were previously treated with a bevacizumab-containing regimen. Patients were randomized to receive 400 mg of oral Nexavar or matching placebo twice daily, in addition to chemotherapeutic agents – gemcitabine or capecitabine. The primary endpoint was progression-free survival, and secondary endpoints included overall survival, time-to-progression and safety.

"We continue to explore the utility of Nexavar as a potential treatment option for breast cancer patients in variety of settings, including in the ongoing RESILIENCE Phase 3 trial," said Dr. Dimitris Voliotis, Vice President, Global Clinical Development Oncology, Bayer HealthCare.  "As the second leading cause of cancer-related death in women, there is still an unmet need for treatments for these advanced patients.  We remain committed to evaluating Nexavar in this patient population."

About the RESILIENCE Phase 3 Breast Cancer Trial

The RESILIENCE trial is
'/>"/>

SOURCE Bayer HealthCare Pharmaceuticals, Inc.; Onyx Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. Nexavar Significantly Improved Overall Survival in Phase 3 Asia-Pacific Liver Cancer Trial
2. ZymoGenetics Reports Positive Phase 1 Results for IL-21 With Nexavar(R)
3. Nexavar First FDA-Approved Drug Therapy for Liver Cancer
4. Nexavar Significantly Improves Overall Survival by 47 Percent in Asia-Pacific Liver Cancer Study
5. New Nexavar Data Presented in Multiple Tumor Types at 44th American Society of Clinical Oncology Annual Meeting
6. The New England Journal of Medicine Publishes Nexavar(R) Study Demonstrating Significant Improvement in Overall Survival in Patients With Liver Cancer
7. Bayer and Onyx Begin Enrollment in STORM Trial Studying Nexavar as Adjuvant Therapy for Patients With Liver Cancer
8. Phase 3 Trial of Nexavar in Chemotherapy-Naive Patients with Advanced Melanoma Does Not Meet Primary Endpoint
9. Bayer and Onyx Announce Nexavar Data Presentations at 60th American Association for the Study of Liver Diseases Annual Meeting
10. Nexavar in Combination With Chemotherapy Demonstrates Activity in Patients With Advanced Breast Cancer in Two Phase 2 Studies
11. Phase 3 Trial of Nexavar in First-Line Advanced Non-Small Cell Lung Cancer Does Not Meet Primary Endpoint of Overall Survival
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... 28, 2014  Isis Pharmaceuticals, Inc. (NASDAQ: ... 2014 Financial Results and Highlights Conference CallWhen:Monday, August 4 ... How:Live on the Internet. Simply log onto our ... during the live event, a replay of the webcast ... www.isispharm.com . ABOUT ISIS PHARMACEUTICALS, INC. Isis ...
(Date:7/28/2014)... , July 28, 2014 ... £2.5 million to help it meet the global ... healthcare, pharmaceuticals and logistics. Albion joins Shackleton Ventures. ... Over the past 18 months OmPrompt ... platform, its management team and its operations. The ...
(Date:7/25/2014)... July 25, 2014  Depomed, Inc. (NASDAQ: ... quarter fiscal year 2014 financial results after the market ... a conference call beginning at 4:30 pm EDT, 1:30 pm PDT ... the call by dialing 877-317-6789 ( United States ... also be available via a live webcast on the ...
Breaking Medicine Technology:Webcast Alert: Isis Pharmaceuticals' Second Quarter 2014 Financial Results Conference Call 2OmPrompt Funded for Customer Automation Management Market Expansion 2Depomed To Report Second Quarter Fiscal Year 2014 Financial Results On Wednesday, August 6, 2014 2
... Feb. 28, 2012   New Mexico Software, Inc. , d/b/a ... NMXC ), a developer of medical IT solutions and ... community, announced today that the company,s long standing suit brought ... judgment in favor of New Mexico Software. The ...
... 2012   Alexander Orthopaedic Associates (AOA) in Largo, FL, ... their practice with White Plume Technologies between Exscribe ... (ADSC) practice management system (PM system). EMRs ... the billing process unfilled. White Plume Technologies bridges ...
Cached Medicine Technology:New Mexico Software Prevails in Lawsuit 2Alexander Orthopaedic Associates Chooses White Plume Technologies to Fill the EMR Gap 2
(Date:7/28/2014)... 2014 Community Health Center of Snohomish ... and pharmacy services, has released an article designed to ... management . Founded in 1983, the health center has ... the county that face barriers to obtaining high quality ... appointment at the CHC, click here: http://www.chcsno.org/locations.ashx?p=1099 ...
(Date:7/28/2014)... Alta Resources , a global provider ... 500 brands, announced today that it plans to fill ... California, Florida and the Philippines. More than 1,200 of ... campus, and the company announced that approximately 700 positions ... several health-insurance clients, which have seasonal ramp-ups that require ...
(Date:7/28/2014)... Labors.at, Austria’s largest and most progressive ... Cloud™ to fuel its growth initiatives. The organization, ... patients daily and performs up to 70,000 diagnostic ... doubling its volume within the next year. ... square meter facility pushed our team to re-evaluate ...
(Date:7/28/2014)... 2014 H2T Elite Dryland Training will be ... 573 Alness Street in Toronto, H2T is focused ... H2T is a state of the art facility that specializes ... are many gyms out there for people 18 and older ... H2T will be home to many elite athletes that will ...
(Date:7/28/2014)... following a healthy lifestyle may lower childhood cancer survivors, ... in CANCER , a peer-reviewed journal of the ... cancer and adults who had cancer when they were ... influence their long-term health. , Adults who had ... risk for the metabolic syndrome, a group of risk ...
Breaking Medicine News(10 mins):Health News:Community Health Center of Snohomish Releases Article Focusing on Educating the Chronically Ill About Chronic Disease Management 2Health News:Community Health Center of Snohomish Releases Article Focusing on Educating the Chronically Ill About Chronic Disease Management 3Health News:Alta Resources To Fill Approximately 1,200 Positions In Fort Myers 2Health News:Alta Resources To Fill Approximately 1,200 Positions In Fort Myers 3Health News:Alta Resources To Fill Approximately 1,200 Positions In Fort Myers 4Health News:Austrian Laboratory Leader, Labors.at, Fuels Growth with the hc1® Healthcare Relationship Cloud™ 2Health News:FS Local Community Member H2T Elite Dryland Training Is Set to Open Its Doors 2Health News:Lifestyle choices may affect the long-term heart health of childhood cancer survivors 2
... that only aims at malignant cells might fall short ... of normal cells which are present long before any ... is going to be, new research suggests. , Such ... the body, residing innocently there until certain cancer genes ...
... [New Jersey plastic surgeon] Dr. Paul M. Parker has been performing ... months. His patients have loved their sculpted tummies and their quick ... added two significant refinements to the procedure making the results and ... ...
... 5000 survey recognizes Alpharetta-based Company for outstanding growth, and success in ... ... 28, 2008 -- www.jacksonhealthcare.com [Jackson Healthcare] (JH) has been ... of the nation,s fastest growing and most entrepreneurial private companies. ...
... another Major Rise in Listeners. Affordable Health Insurance and Health ... ... City, MO (PRWEB) August 28, 2008 -- The Health Insurance Advocate ... 6th on 1260 AM and 104.1 FM KSGF. The weekly ...
... Volunteer to take part in Signature,Chefs Auction Galas, ... a kitchen near you: Chef Rahman "Rock" Harper will ... Chef Auctions open to the public,nationwide this fall., ... celebrity chef,spokesperson. In this role, Chef Rock, winner of ...
... for Efforts to Create Sensible Fire Safety ... ... have voted to maintain California,s tough fire,standards by striking down proposed fire ... of sensible,legislation to address fire safety regulations in the state. The bill ...
Cached Medicine News:Health News:Normal Cells May Predict Cancer Virulence 2Health News:Lipoabdominoplasty: A New Type of Tummy Tuck Gets Even Better 2Health News:Lipoabdominoplasty: A New Type of Tummy Tuck Gets Even Better 3Health News:Lipoabdominoplasty: A New Type of Tummy Tuck Gets Even Better 4Health News:Jackson Healthcare Ranked 48th of All Health Companies on Inc. Magazine's 2008 List of 5000 Fastest Growing Private Companies 2Health News:The Health Insurance Advocate Radio Show Expands to Springfield, Missouri, and Reaches a New All-Time Ratings High for Female Listenership 2Health News:The Health Insurance Advocate Radio Show Expands to Springfield, Missouri, and Reaches a New All-Time Ratings High for Female Listenership 3Health News:Chef Rock to Rock Signature Chefs Auctions(R) Nationwide 2Health News:California Senate Rejects Proposed Effort to Weaken Fire Safety Standards 2
The Advia 60 is designed to deliver powerful performance in a small package....
... three-dimensional VCS technology, providing ... efficiency in white cell ... With its reputation for ... is an affordable solution ...
Creatinine Test Kit (enzymatic), Wavelength: 340 nm. Linear range: up to 20 mg/dL....
For the quantitative determination of Creatine Kinase in serum....
Medicine Products: