Navigation Links
Nexavar in Combination With Chemotherapy Demonstrates Activity in Patients With Advanced Breast Cancer in Two Phase 2 Studies
Date:12/11/2009

WAYNE, N.J. and EMERYVILLE, Calif., Dec. 11 /PRNewswire-FirstCall/ -- Bayer HealthCare Pharmaceuticals and Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX) today announced results from two collaborative group-sponsored randomized, double-blind, placebo-controlled Phase 2 trials were presented at the 32nd Annual San Antonio Breast Cancer Symposium (SABCS). The first of these studies evaluated Nexavar® (sorafenib) tablets in combination with chemotherapy agent capecitabine and the second study evaluated Nexavar in combination with paclitaxel.

"Onyx and Bayer are encouraged by these results as they suggest Nexavar may have potential as a combination therapy for advanced breast cancer patients in both the first and second-line setting," said Todd Yancey, M.D., senior vice president of clinical development at Onyx. "These findings, in particular the statistically significant results demonstrated with Nexavar in combination with capecitabine, are the basis for a registrational Phase 3 program that is expected to begin next year."

Nexavar in Combination with Capecitabine

The randomized, double-blind, placebo-controlled Phase 2 study evaluated Nexavar in combination with the oral chemotherapeutic agent, capecitabine, in 229 patients. These patients had locally advanced or metastatic HER-2 negative breast cancer and had received no more than one prior chemotherapy in this setting.

Patients receiving capecitabine plus Nexavar had a 74 percent improvement in progression-free survival as compared to those who received chemotherapy alone. The increase in median progression-free survival of capecitabine plus Nexavar versus capecitabine plus placebo was statistically significant (median 6.4 months vs. 4.1 months, HR=.576, p=0.0006).

In a post-hoc, subgroup analysis of first-line pati
'/>"/>

SOURCE Onyx Pharmaceuticals, Inc.; Bayer HealthCare Pharmaceuticals Inc.
Copyright©2009 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Nexavar Significantly Improved Overall Survival in Phase 3 Asia-Pacific Liver Cancer Trial
2. ZymoGenetics Reports Positive Phase 1 Results for IL-21 With Nexavar(R)
3. Nexavar First FDA-Approved Drug Therapy for Liver Cancer
4. Nexavar Significantly Improves Overall Survival by 47 Percent in Asia-Pacific Liver Cancer Study
5. New Nexavar Data Presented in Multiple Tumor Types at 44th American Society of Clinical Oncology Annual Meeting
6. The New England Journal of Medicine Publishes Nexavar(R) Study Demonstrating Significant Improvement in Overall Survival in Patients With Liver Cancer
7. Bayer and Onyx Begin Enrollment in STORM Trial Studying Nexavar as Adjuvant Therapy for Patients With Liver Cancer
8. Phase 3 Trial of Nexavar in Chemotherapy-Naive Patients with Advanced Melanoma Does Not Meet Primary Endpoint
9. Bayer and Onyx Announce Nexavar Data Presentations at 60th American Association for the Study of Liver Diseases Annual Meeting
10. CuraGen and TopoTarget Initiate Phase I/II Clinical Trial of Belinostat (PXD101) Combination Therapy for Acute Myeloid Leukemia
11. Abbott and AstraZeneca Announce Selection of Next-Generation Fenofibrate ABT-335 and CRESTOR(R) Fixed-Dose Combination
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/17/2013)... DIEGO and CAMBRIDGE, Mass., May 17, 2013 /PRNewswire/ ... that a purchaser of Aveo Pharmaceutical, Inc. (NASDAQGS: AVEO) ... Court for the District of Massachusetts ... its officers violated the Securities Exchange Act of 1934 ... 1, 2013 (the "Class Period"). (Logo: ...
(Date:5/17/2013)... YORK , May 17, 2013 /PRNewswire-iReach/ -- United ... Advanced Cardiac Life Support (ACLS), Pediatric Advanced Life Support ... free PALS, BLS and ACLS online course ... manuals, people simply need to build an account with ... materials for these programs, United Medical Education is setting ...
(Date:5/17/2013)... announced that it will report its 2013 first quarter earnings on Wednesday, ... Ed Borkowski , CFO, will host an analyst and investor ... participate in the conference call within the U.S. and Canada ... call outside the U.S. and Canada , dial (760) ... should dial in 10 minutes prior to the start of the call. ...
Breaking Medicine Technology:Aveo Pharmaceuticals, Inc. Sued by Investor 2Aveo Pharmaceuticals, Inc. Sued by Investor 3ACLS Online Course Manuals are Now Available at No Cost through United Medical Education 2
... , , LONDON, Dec. 14 The ... the Ultrasound Market is conferred on SonoScape. The award recipient ... special features, pricing, and portability - and introduced the S8 ... Doppler HCU compares with that of a regular, high-end, cart-based ...
... MALVERN, Pa., Dec. 14 Fujirebio Diagnostics Inc., a Malvern-based ... by the Eastern Technology Council at a gala dinner held ... 2009. , The Eastern Technology Council is the ... as "The Academy Awards" of the Technology and Life Sciences ...
Cached Medicine Technology:Frost & Sullivan Product Quality Leadership Award in the European Ultrasound Market Conferred on SonoScape for S8 2Frost & Sullivan Product Quality Leadership Award in the European Ultrasound Market Conferred on SonoScape for S8 3Fujirebio Diagnostics Named Life Sciences Company of the Year 2
(Date:5/18/2013)... (PRWEB) May 18, 2013 Assisted ... it comes to safety and comfort of their ... and provides clients with an effective and cost-efficient ... This is an integrated, turnkey communications solution that ... while allowing residents independence and privacy. , ...
(Date:5/18/2013)... 2013 The Communities of Distinction TV ... we call home. These are the townships, villages and other ... locations where the people are friendly and neighbors are there ... the highways and shares the best in both the United ... an American sports and film celebrity. It airs in May ...
(Date:5/18/2013)... May 18, 2013 TheBeautyPlace.com answers important ... hair loss is not a result of stress, nutrient ... Men’s Fitness Magazine, 70% of men suffer from male ... is renowned for hair transplant surgery, but additionally ... pattern baldness known as Bosley Professional Strength. Their product ...
(Date:5/18/2013)... 18, 2013 Although obesity is associated ... association between obesity and esophageal adenocarcinoma, a type of ... tumors. As reported on Cancer.gov, last reviewed ... twice as likely as those of normal and healthy ... between obesity and esophageal cancer is not well understood, ...
(Date:5/18/2013)... (PRWEB) May 18, 2013 Adolescents, especially ... known as “Spice” or “K2” are landing in emergency ... to curb this drug epidemic with a new ... marijuana. , According to research from the National Institute ... popular illegal drug among American teenagers. In 2012, 11 ...
Breaking Medicine News(10 mins):Health News:VisionLink Nurse Call System's New Features Serve the Unique Needs of Retirement Communities 2Health News:VisionLink Nurse Call System's New Features Serve the Unique Needs of Retirement Communities 3Health News:Communities of Distinction TV Presents "A Place to Call Home" Segment 2Health News:TheBeautyPlace.com Features the Two New Best-Selling Hairloss Products: Bosley Professional Strength and Nioxin Systems 2Health News:TheBeautyPlace.com Features the Two New Best-Selling Hairloss Products: Bosley Professional Strength and Nioxin Systems 3Health News:hCGtreatments / Diet Doc Hcg Diets & Weight Loss Plans Announces New Prescription Hcg Diet Plans Designed to Trim Inches and Thus Reduce the Risk of Esophageal Cancer 2Health News:hCGtreatments / Diet Doc Hcg Diets & Weight Loss Plans Announces New Prescription Hcg Diet Plans Designed to Trim Inches and Thus Reduce the Risk of Esophageal Cancer 3Health News:Spice Addiction Treatment and Synthetic Marijuana Drug Rehab Announced by Recovery Associates 2
... Redenbacher,s SmartPop! can help ,take the edge off, manage ... controlled snack, such as Orville Redenbacher,s 94 percent fat-free ... curb hunger without increasing total calorie intake, says a ... Dr. James Rippe of the Rippe Lifestyle Institute, the ...
... New research published in the April issue of ... indicates that large numbers of physician assistants and ... have been hired by general surgery residency programs ... education experience, and these professionals continue to be in ...
... recruitment and retention, organizational relationships citedGAITHERSBURG, Md., ... food and facilities management services company, was ... Ten Companies for Latinos list, based on ... diversity and corporate/organizational communications from more than ...
... cause children real problems , , MONDAY, April 20 (HealthDay ... players -- fully 8.5 percent -- exhibit signs of ... These kids aren,t just playing a lot. Their gaming ... friends and poses health problems, the study reveals. , ...
... help readers find healthier ways to shop, cook and ... physician Preston Maring has been recognized by EatingWell, publisher ... EatingWell books, for his work to make locally ... care physician, authored the introduction for a new cookbook, ...
... to America,s aging population and the acknowledged gaps in ... to find creative approaches to address one of the ... society where in two decades one of every five ... make quality care for the elderly more efficient and ...
Cached Medicine News:Health News:Squeezing Calories? New Study Finds That Low-Fat Popcorn Before Lunch Does Not Increase Total Calorie Intake 2Health News:Surgical education programs have demand for physician assistants and nurse practitioners 2Health News:Sodexo Ranks Second on the 2009 DiversityInc Top Ten Companies for Latinos List 2Health News:Sodexo Ranks Second on the 2009 DiversityInc Top Ten Companies for Latinos List 3Health News:Almost 1 in 10 Young Video Game Users 'Addicted' 2Health News:Almost 1 in 10 Young Video Game Users 'Addicted' 3Health News:Kaiser Permanente Physician Celebrated for Contributions to Locally Grown Food Movement 2Health News:Kaiser Permanente Physician Celebrated for Contributions to Locally Grown Food Movement 3Health News:Healthcare Gathering Addresses Increasing Need of Caring for the Nation's Elderly Population 2Health News:Healthcare Gathering Addresses Increasing Need of Caring for the Nation's Elderly Population 3
Hartman Mosquito forceps, straight serrated jaws, ring handle, dull finish, overall length 75 mm....
Straight 21 mm serrated jaws. Ring handle with ratchet lock. Non-magnetic and dull finish. Overall length 4.8 inches....
Straight shafts with 13 mm crisscross serrated platform with polished finish. Serrated handle....
Straight shafts with 15 mm long jaws. Serrated handle with polished finish. Smooth jaws....
Medicine Products: