NexBio(R) Publishes Two Articles Showing DAS181 (Fludase(R)*) Potently Inhibits Pandemic Influenza A(H1N1) and NAI-Resistant Influen...(isolates of seasonal H1N1 influenza viru...),Health

Date:11/6/2009

isolates of seasonal H1N1 influenza virus collected from influenza patients during 2004, 2007, and 2009 was studied. The isolates from 2007 and 2009 are all resistant to Tamiflu® as all contain the H274Y mutation known to cause such resistance. Notably, all isolates were strongly inhibited by DAS181. Additionally, NexBio has data to demonstrate that a laboratory strain of influenza which is resistant to all three NAIs (oseltamivir, zanamivir, peramivir) in vitro was inhibited by DAS181 in cell culture and in animals in the study.

"These results are particularly important because of the current H1N1 pandemic and the urgent need for new antiviral drugs with different approaches from currently available NAIs. Neuraminidase inhibitor drug resistance is already a significant problem for seasonal influenza. Tamiflu® drug resistance caused by the same mutation in Pandemic Influenza A(H1N1) is now being seen worldwide" commented Dr. Fang Fang, NexBio's President of Research & Development. "Unique among licensed influenza drugs and those in clinical development, DAS181 uses a Host-Oriented Therapeutic (HOT) strategy. Our goal for the continued advanced clinical development of DAS181 is to bring a potentially important new medicine to the treatment and prevention of this worldwide problem," Dr. Fang added

ABOUT NEXBIO

NexBio, Inc. is a privately held clinical-stage biopharmaceutical company located in San Diego. NexBio's mission is to save lives and to improve the quality of life by creating and commercializing novel, broad-spectrum biopharmaceuticals to prevent and treat current and emerging life-threatening diseases. DAS181 (Fludase®), is an investigational drug that consists of an inhaled recombinant fusion protein. It inactivates viral receptors on the cells of the human respiratory tract, thereby preventing and treating infection by influenza, including potential pandemic strains, and by
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SOURCE NexBio, Inc. Copyright©2009 PR Newswire. All rights reserved

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