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NexBio(R) Presents DAS181 (Fludase(R)*) Potently Inhibits Novel Swine-Origin A(H1N1) and NAI-Resistant Influenza Viruses, at ICAAC 2009
Date:9/13/2009

at the meeting suggested that DAS181 exhibited potent inhibitory activity against these Novel H1N1 viruses in these different models.

The related presentation, entitled "In Vivo and In Vitro Activity of DAS181 Against NAI-Resistant Influenza Virus" examined the in vivo and in vitro activity of DAS181 against patient isolates of community-acquired seasonal influenza from the 2008-2009 influenza season. All isolates had the H274Y mutation associated with resistance to Tamiflu. DAS181 in vitro was an effective inhibitor of Tamiflu-resistant influenza virus. In addition, in vivo mouse challenge studies with another NAI-resistant strain demonstrated strong sensitivity to DAS181 treatment.

Both studies are presented by Ronald Moss M.D., Executive Vice President, Clinical Development and Medical Affairs. "Based on these encouraging data we are moving forward with our ongoing clinical development of DAS181, and we will continue to work closely with FDA, CDC, and NIH on this clinical program during the current pandemic," stated Dr. Moss. "Because of viral evolution, alternatives to current treatment strategies are needed to deal with potential drug resistance. DAS181 may play an important role for public health preparedness during influenza pandemics."

ABOUT NEXBIO

NexBio, Inc. is a privately held clinical-stage biopharmaceutical company located in San Diego. NexBio's mission is to save lives and to improve the quality of life by creating and commercializing novel, broad-spectrum biopharmaceuticals to prevent and treat current and emerging life-threatening diseases. DAS181 (Fludase(R)), a recombinant fusion protein, inactivates viral receptors on the cells of the human respiratory tract, thereby preventing and treating infection by influenza, including potential pandemic strains, and by parainfluenza viruses (which may cause serious respiratory illness similar to i
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SOURCE NexBio, Inc.
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