Navigation Links
Newly Published Phase II Study Shows the Investigational Drug Vandetanib Prolongs Progression-Free Survival in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC)
Date:9/21/2007

- Phase III trials now underway to evaluate vandetanib as second-line NSCLC

treatment in combination with docetaxel -

WILMINGTON, Del., Sept. 20 /PRNewswire/ -- Results published today in the Journal of Clinical Oncology(1) show that the AstraZeneca investigational once-daily oral anti-cancer drug vandetanib (ZACTIMA), in combination with docetaxel, improved progression free survival (PFS) in patients with advanced Non-Small Cell Lung Cancer (NSCLC).

The Phase II trial - Study 6 - compared the combination of vandetanib 100mg or 300mg plus docetaxel to standard docetaxel alone. The trial demonstrated that adding vandetanib to standard docetaxel therapy prolonged median PFS to 18.7 weeks and 17 weeks respectively, compared to 12 weeks with docetaxel alone.(2)

"Given the poor prognosis in advanced non-small cell lung cancer, an increase in time to disease progression can be meaningful to patients," said Study 6 lead author John Heymach, Assistant Professor of Thoracic Head/Neck Medical Oncology at the University of Texas MD Anderson Cancer Centre . "The results of Study 6 provide encouraging support, and reinforce further investigation with ZACTIMA in combination with chemotherapy in Phase III trials."

Based on these data, AstraZeneca has initiated a Phase III trial, currently underway, to evaluate vandetanib and docetaxel in second-line treatment of non-small cell lung cancer. The ZODIAC (ZACTIMA in cOmbination with Docetaxel In non-smAll cell lung Cancer), trial is a randomised, double- blind study evaluating vandetanib 100mg in combination with docetaxel vs. docetaxel alone, in patients with locally advanced or metastatic NSCLC after failure of first-line treatment.

The study is recruiting and aims to enroll approximately 1400 patients worldwide at over 250 centers throughout Europe, North America, South America and Asia Pacific. The primary end points of the study are to assess PFS. Response rates and overall Sur
'/>"/>

SOURCE AstraZeneca
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Velcade (bortezomib) for Injection Based Therapies Achieved Survival Rates as High as 100 Percent in Newly Diagnosed Multiple Myeloma Patients
2. Newly Published Data from Large Study Support Cardiovascular Safety of Avandia (Rosiglitazone Maleate)
3. Newly Published Data Demonstrates Superiority of Cipralex Over Duloxetine for Acute Treatment of Depression
4. Adding Thalidomide to Standard Therapy Improves Survival in Newly Diagnosed Multiple Myeloma Patients Over Age 75
5. Newly Published Study Reveals Femara Improves Chances for Harder to Treat Early Breast Cancer Relapse in Postmenopausal Women
6. New Analysis of Data from WHI Provides Reassurance With Respect to Coronary Heart Disease For Newly Menopausal Women Considering Hormone Therapy
7. ECOG Phase III Newly Diagnosed Multiple Myeloma Trial (E4A03) Reports Lenalidomide Plus Low-Dose Dexamethasone Suggests Survival Advantage for Patients with Multiple Myeloma
8. MRI Detects Cancers in the Opposite Breast of Women Newly Diagnosed with Breast Cancer
9. Nymox Announces Positive Results from Newly Completed Long-term Study of NX-1207 for Benign Prostatic Hyperplasia
10. Newly Released Canadian Data Links Vaccines with Pervasive Developmental Disorder
11. New Phase 3 Study Published in The Lancet Evaluates Efficacy and Safety of Prezista/Ritonavir vs. Kaletra as Part of HIV Combination Therapy in Treatment-Experienced Adults With HIV
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/vzhr6h/video ) has ... Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - ... has been the topic of fascination since the era of ... and the Soviet Russia. Earlier even a small glimpse ...
(Date:1/23/2015)... analysis of Centers for Medicare and Medicaid Services, (CMS) ... percent of seniors chose lower-cost preferred pharmacy plans that ... The findings were released by Drug Channels . ... of Medicare Part D," said Pharmaceutical Care Management Association ...
(Date:1/23/2015)... DUBLIN , Jan. 23, 2015  Immune Therapeutics, Inc. today ... Inc. for the compounding, packaging and distributing of its naltrexone ... the United States . KRS ... compounding naltrexone tablets in various strengths for individual patients in ...
Breaking Medicine Technology:Video Telemedicine Market- Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Video Telemedicine Market- Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3New Analysis: 81 Percent of Medicare Part D Seniors Choose "Preferred Pharmacy" Plans in 2015 2Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 2Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 3Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 4
... -- Vinod Gupta grew up in a family of self-made ... still works as a physician. So it,s no surprise a ... American Dream by forming his own company, Business Research Services. ... launched its initial public offering in 1993. It eventually became ...
... Dicom Systems ( http://www.dcmsys.com ), healthcare IT company ... selection as the Vendor Neutral Archive (VNA) vendor of ... group. Dicom Systems, VNA works with ... turn your current storage to your PACS archive at ...
Cached Medicine Technology:B2B Omaha Magazine Features Vin Gupta in Latest Edition Guru Credits Education as the Reason For His Success 2B2B Omaha Magazine Features Vin Gupta in Latest Edition Guru Credits Education as the Reason For His Success 3ONRAD, Inc. Chooses Dicom Systems' Vendor Neutral Archive 2
(Date:1/22/2015)... January 23, 2015 Recently, Weddingshe.com has added ... and has announced its highest annual revenues in the past ... its popular glamorous wedding dresses. , According to the sales ... wedding dress promotions for them in 2015. This point can ...
(Date:1/22/2015)... DC (PRWEB) January 22, 2015 Payday ... in vulnerable communities and cause financial distress to the ... by analysts at Howard University’s Center on Race and ... dollars in economic activity, payday loans at the same ...
(Date:1/22/2015)... January 22, 2015 JJsHouse.com is a famous ... Today, the business announces its latest collection of wedding ... “The most important issue is the wedding dress on your ... in a woman’s life. Every bride wants to find the ...
(Date:1/22/2015)... VA (PRWEB) January 22, 2015 Step ... power at the Science Museum of Virginia. Wicked Plants, ... , Wicked Plants unearths 75 poisonous, carnivorous and diabolical ... through each room to uncover the biochemical, physical and ...
(Date:12/26/2014)... 2014 It is said that nothing makes ... UWDress.com, the famous wedding dress supplier, shows its new ... cocktail gown promotion. , UWDress.com’s navy cocktail gowns are ... come in high fashion styles. Simple dresses in bright neon ...
Breaking Medicine News(10 mins):Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:Find The Most Suitable Wedding Dress At JJsHouse.com 2Health News:Wicked Plants are taking over the Science Museum of Virginia 2Health News:UWDress.com Shows Its New Navy Cocktail Dresses For 2015 2
... accepted for publication in The Endocrine Society,s Journal of ... type 1 diabetes have now been found to have abnormal ... affect heart, blood vessel and exercise function in this population. ... with type 2 diabetes have their insulin resistance measured routinely, ...
... , TORONTO, Dec. 1 /PRNewswire/ - Sentinelle ... and 4D advanced visualization software, extends its line of ... of North America (RSNA) annual meeting in Chicago, Nov. ... , With the unique Vanguard(R) patient support design and ...
... ... to go into internal medicine to help fulfill an unmet need. , ... North Brunswick, NJ (PRWEB) December 1, 2009 -- ... medical student at Ross University School of Medicine--knew he could go into any area of ...
... ... advocate for, and support programs and services for adolescents and adults with Autism Spectrum Disorders ... Recognize The Signs and Basic First Aid When You Do." , ... New York, NY (PRWEB) December 1, 2009 -- Statistics ...
... Dec. 1 Cell Therapeutics, Inc. (CTI) (Nasdaq and MTA: CTIC) management,s ... 11:00 a.m. Eastern Time will be webcast live at www.celltherapeutics.com . , ... will also be available for replay after the presentation. , , ... Piper Jaffray Health Care Conference, ...
... using functional magnetic resonance imaging (fMRI) to evaluate brain ... as children incur permanent brain injury. The results were ... Society of North America (RSNA). "What we have ... spared from lead exposure," said the study,s lead author, ...
Cached Medicine News:Health News:Cardiovascular risk in youth with type 1 diabetes linked primarily to insulin resistance 2Health News:Sentinelle Medical Introduces New Suite of Breast MRI Coils for GE, Siemens and Toshiba Scanners 2Health News:Sentinelle Medical Introduces New Suite of Breast MRI Coils for GE, Siemens and Toshiba Scanners 3Health News:Trending Against the Norm: How One Top Scoring Ross University Medical Student is Choosing to Make a Difference in Internal Medicine 2Health News:Daniel Jordan Fiddle Foundation for Adults with Autism Offers Free Epilepsy First-Aid Brochure 2Health News:Daniel Jordan Fiddle Foundation for Adults with Autism Offers Free Epilepsy First-Aid Brochure 3Health News:Daniel Jordan Fiddle Foundation for Adults with Autism Offers Free Epilepsy First-Aid Brochure 4Health News:Childhood lead exposure causes permanent brain damage 2
The Auto Suture DFS stapler is a disposable fascia stapler. The stapler places one staple each time the instrument handles are activated. The staples first penetrate the fascia and are then formed, t...
... PROXIMATE RH skin stapler is a full-feature ... assembly., ,PROXIMATE RH has improved visibility ... with a ratchet mechanism for easier staple ... sterile, single patient use instrument designed to ...
... Reloadable Linear Staplers deliver two staggered rows of ... They may be reloaded up to three times ... fire heavy wire staples for thick tissue. The ... interchangeable., ,Benefits include: , Parallel jaw closure ...
... Use Loading Units for use ... Use Reloadable Staplers with Titanium ... TA™ Reloadable staplers has application ... thoracic surgical procedures for resection ...
Medicine Products: