Navigation Links
Newly-Published Colchicine Safety Data Provide First Evidence-Based Dosing Guidance to Avoid Potentially Serious Interactions With Commonly Prescribed Drugs
Date:8/11/2011

be reduced between one-third and two-thirds for acute flares, and by 50 to 75 percent for flare prophylaxis, when used as concomitant therapy with six of the seven drugs studied. No colchicine dose adjustments were necessary when used with azithromycin.

In the case of ritonavir, the discovery of serious interactions with colchicine prompted the FDA on May 5, 2010 to require that the new dosing recommendations be included in the prescribing information of all protease inhibitors.

"Despite the fact that colchicine has been used for decades in the prevention and treatment of gout flares and for FMF, the pharmacokinetics and metabolism of colchicine have not been extensively studied, until now," said Robert A. Terkeltaub, M.D., Interim Division Chief and Professor of Medicine at the University of California San Diego and the VA Medical Center, and the paper's lead author. "The results of these studies form the foundation of evidence-based dosing guidance for colchicine in the presence of CYP3A4 or P-gp inhibitors that help achieve optimal therapeutic benefit while avoiding dangerous and unnecessary safety risks."

Safety issues resulting from the concurrent use of colchicine with CYP3A4 or P-gp inhibitors have been documented in the past. At least 60 deaths have been linked to colchicine in patients who were also taking clarithromycin, but there have been no published studies characterizing these interactions, nor any suggestions or recommendations to modify colchicine dosing, according to the authors.

"The need to understand, and avoid, colchicine drug-drug interactions is greater than ever, especially in people with gout," said Matthew W. Davis, M.D., R.Ph., Chief Medical Officer, URL Pharma and a co-author of the paper. "Many gout patients struggle with obesity and have multiple co-morbid conditions, including hypertension, diabetes, metabolic syndrome and renal insufficiency, which may require patients to be on multiple medications. The
'/>"/>

SOURCE URL Pharma, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Data Presented at ACR Meeting Demonstrate Safety of Colcrys® (Colchicine, USP) for Treatment of Gout Flares in Patients with Multiple Co-Morbid Conditions
2. FDA Orders Halt to Marketing of Unapproved Single-Ingredient Oral Colchicine
3. LabGard ES NU-629 Animal Biological Safety Cabinet Updates
4. Elekta Emphasizes Commitment to Safety in Cancer Management at Joint Radiation Physics Annual Meeting
5. Royal Victoria Hospital Selects Omnicell to Improve Patient Safety with Automated Medication Management
6. FDA CONSUMER HEALTH INFORMATION - FDAs MedWatch Safety Alerts: June 2011
7. Cal/OSHA Fines Prominent Pharmaceutical Firm $371,000 for Safety Violations Leading to Worker Fatality
8. EDURANT™ 96-Week Phase 3 Safety and Efficacy Data Presented at International AIDS Society Conference
9. Ansell Limited Acquires Sandel Medical Industries LLC, an Innovator in Surgical Safety Solutions
10. ECRI Institute and Health Care Improvement Foundation Launch CT Radiation Safety Collaborative
11. First Annual Pediatric Medication Safety Summit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... LOS ANGELES , July 11, 2014 /PRNewswire-iReach/ ... of e-liquid, a vegetable-glycol solution for use in ... one of the active ingredients in cannabis, cannabidiol ... in personal vaporizer devices, and other vaporizer technology. ... Cannabis naturally contains 483 different compounds ...
(Date:7/11/2014)... CHAPEL HILL, N.C. , July 11, 2014 ... component of pharmaceutical marketing and, consequently, organizations are ... specifically for patients. As part of ... learned it,s important to educate, communicate and engage ... from disease awareness to patient empowerment. By mapping ...
(Date:7/11/2014)... , July 11, 2014 The ... are evolving across industry sectors to better identify ... better ways to engage with and understand consumers, ... themselves and make critical purchasing decisions. ... Best Practices, LLC, one area where organizations can ...
Breaking Medicine Technology:VAPETEK Releases CBD-Infused eLiquid For The Consumer Market 2New Study Uses Six-Step Patient Journey as Framework for Consumer-Focused Marketing Opportunities 2New Technologies Transforming Consumer Marketing Research Playbook 2
(Date:7/12/2014)... York, NY (PRWEB) July 12, 2014 As ... (the National Institute of Standards and Technology), the June 25th, ... the electronic discovery world. It was also ... finally in, depending on whether it was seen from an ... But this much is fact, there is now precedent which ...
(Date:7/12/2014)... July 12, 2014 Praeclarus Press ... Simple as a valuable new resource for women in ... of American women work away from their children. Today’s ... the benefits of breastfeeding, but often feel unsupported when ... their babies. With its evidence-based insights, and written by ...
(Date:7/12/2014)... Beach, FL (PRWEB) July 12, 2014 ... of high-quality peptides that are used solely in scientific ... honor two successful years in business, Maxim Peptide, which ... has just launched a new and updated website that ... research blog section has been updated with fascinating articles ...
(Date:7/11/2014)... Recently, DressyQuinceanera.com, a well-known wedding dress manufacturer ... to its online category. Furthermore, the firm has ... discounted rates, up to 62% off. , The brand ... in terms of quality and style. All items in ... also offered for the company’s other items: lace evening ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 As ... filed against Johnson & Johnson’s Ethicon Inc. unit ... LLP notes that the Texas Attorney General’s Office ... marketing of surgical mesh products used to treat ... to a report from kens5.com, the probe began ...
Breaking Medicine News(10 mins):Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 2Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 3Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 4Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 5Health News:Praeclarus Press Announces the Release of Working and Breastfeeding Made Simple by Nancy Mohrbacher, A Much Needed Resource For Today's Working Mothers 2Health News:Maxim Peptide Celebrates Second Anniversary Online with an Updated Website and Special Deals Section 2Health News:DressyQuinceanera.com: Beautiful Quinceanera Dama Dresses At Low Prices 2Health News:Transvaginal Mesh Lawsuit News: Bernstein Liebhard LLP Notes Report of Texas Probe into Ethicon Pelvic Mesh Marketing 2Health News:Transvaginal Mesh Lawsuit News: Bernstein Liebhard LLP Notes Report of Texas Probe into Ethicon Pelvic Mesh Marketing 3Health News:Transvaginal Mesh Lawsuit News: Bernstein Liebhard LLP Notes Report of Texas Probe into Ethicon Pelvic Mesh Marketing 4
... The Department of Labor,s,Occupational Safety and Health ... the review of its methylene chloride (MC),Standard (29 ... in,the July 10, 2007, Federal Register (72 FR ... in 1997 to protect employees from occupational,exposure to ...
... issue of Cell Metabolism, a publication of Cell Press, provides ... contribute to building muscles up in response to exercise. These ... muscle loss that occurs in diseases such as cancer and ... to the researchers. , The researchers showed that a transient ...
... Older men with chronic anxiety are at substantially higher risk, ... men who suffer from chronic anxiety substantially increase their risk ... While stress has been linked to an increased risk of ... has been identified as a risk factor also. , "There ...
... CHICAGO (January 08, 2008) - Each year, cardiovascular disease ... are aware that lifestyle choices such as eating right, ... cardiovascular disease, they may not know that by just ... also be avoiding this potentially lethal condition. , ...
... population growth since the beginning of the XXth Century, ... slave trade and colonization. The regions population in fact ... in 2005. The latest United Nations projections, published in ... billion inhabitants being reached between the present and 2050., ...
... Annual Meeting features the latest cutting-edge findings in ... years meeting focuses on innovative research, novel technologies, ... new approaches to cancer prevention. , To help ... program schedule and related scientific abstracts will be ...
Cached Medicine News:Health News:OSHA Extends Comment Period for Lookback Review of Methylene Chloride Standard 2Health News:New insight into factors that drive muscle-building stem cells 2Health News:Anxiety Raises Heart Attack Risk 2Health News:Anxiety Raises Heart Attack Risk 3Health News:A healthy smile may promote a healthy heart 2Health News:Sub-Saharan Africa: the population emergency 2Health News:Sub-Saharan Africa: the population emergency 3
Spectrafuge 16M High speed microcentrifuge. High g-force for molecular biology applications. Brushless, maintenance-free motor. Easy to use control panel. Complete with 18 x 1.5/2.0 ml rotor. StripSp...
... designed to accommodate the deep-well Plate Rotor 2 ... more than 5600 x g for centrifuging QIAGEN ... fixed-angle and swing-out rotors are available from Sigma ... and 50 ml tubes, as well as 1.5 ...
... and BR4i refrigerated multifunction centrifuges are equally capable ... a low sound level with a large range ... AUTO-LOCK rotor exchange system without tools ensures that ... seconds. Instant rotor exchange (5 sec.) ...
Inquire...
Medicine Products: