Navigation Links
Newly-Published Colchicine Safety Data Provide First Evidence-Based Dosing Guidance to Avoid Potentially Serious Interactions With Commonly Prescribed Drugs
Date:8/11/2011

PHILADELPHIA, Aug. 11, 2011 /PRNewswire/ -- Newly-published results from a series of colchicine safety studies provide physicians with the first evidence-based dosing guidance for colchicine when co-administered with certain commonly prescribed drugs, helping doctors and patients avoid serious and potentially life-threatening drug-drug interactions.

The study results, published in a paper titled "Evidence Basis of a Novel Colchicine Dose Reduction Algorithm to Predict and Prevent Colchicine Toxicity in the Presence of P-gp/CYP450 3A4 Inhibitors," appear in the August issue of Arthritis & Rheumatism, the journal of the American College of Rheumatology. The paper recommends colchicine dose reductions when used with medications such as immunosuppressants, antibiotics, hypertension drugs, anti-fungals and protease inhibitors.

The seven studies highlighted in the paper formed part of the basis for URL Pharma's New Drug Application (NDA) for Colcrys® (colchicine, USP). Colcrys is the only single-ingredient colchicine product to be reviewed and approved by the U.S. Food and Drug Administration, and is indicated for the prophylaxis and treatment of gout flares, and for the treatment of Familial Mediterranean Fever (FMF).

The studies assessed cyclosporine, an immunosuppressant; clarithromycin and azithromycin, two antibiotics; diltiazem and verapamil, two hypertension drugs; ketoconazole, an anti-fungal drug; and ritonavir, a protease inhibitor. Each of these drugs is known to inhibit cytochrome P450 3A4 (CYP3A4) and/or P-glycoprotein (P-gp).

Each of these drugs, except for azithromycin, was found to interact significantly with standard colchicine dosing regimens, in some cases more than doubling levels of colchicine in the blood and increasing the risk of serious toxicities. Cyclosporine and clarithromycin in particular increased peak colchicine blood levels by nearly 300 percent. The authors recommended that colchicine doses
'/>"/>

SOURCE URL Pharma, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Data Presented at ACR Meeting Demonstrate Safety of Colcrys® (Colchicine, USP) for Treatment of Gout Flares in Patients with Multiple Co-Morbid Conditions
2. FDA Orders Halt to Marketing of Unapproved Single-Ingredient Oral Colchicine
3. LabGard ES NU-629 Animal Biological Safety Cabinet Updates
4. Elekta Emphasizes Commitment to Safety in Cancer Management at Joint Radiation Physics Annual Meeting
5. Royal Victoria Hospital Selects Omnicell to Improve Patient Safety with Automated Medication Management
6. FDA CONSUMER HEALTH INFORMATION - FDAs MedWatch Safety Alerts: June 2011
7. Cal/OSHA Fines Prominent Pharmaceutical Firm $371,000 for Safety Violations Leading to Worker Fatality
8. EDURANT™ 96-Week Phase 3 Safety and Efficacy Data Presented at International AIDS Society Conference
9. Ansell Limited Acquires Sandel Medical Industries LLC, an Innovator in Surgical Safety Solutions
10. ECRI Institute and Health Care Improvement Foundation Launch CT Radiation Safety Collaborative
11. First Annual Pediatric Medication Safety Summit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... YORK , August 21, 2014 ... Israeli subsidiary, BreedIT Ltd., the exclusive worldwide license ... software for plant breeders and researchers, today is ... a joint venture with Seach Ltd, a leading ... formed to research and develop new breeds of ...
(Date:8/21/2014)... FAIRFAX, Va. , Aug. 21, 2014 /PRNewswire/ ... real-time quality and Manufacturing Intelligence , today ... Intelligence Conference. The event will be held Oct. ... Mile, and is designed to showcase the necessity ... use of metrics and Manufacturing Intelligence to gain ...
(Date:8/21/2014)... 21, 2014 CVS Caremark Corporation (NYSE: ... Yields and consideration payable in connection with its previously announced ... 2014 for (1) any and all of its 6.250% Senior ... up to a maximum amount of its 6.125% Senior Notes ... Notes due 2017 (collectively, the "Maximum Tender Offer Notes" and ...
Breaking Medicine Technology:BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 2BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 3BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 4InfinityQS to Host Manufacturing Intelligence Conference in Chicago 2CVS Caremark Corporation Announces Early Results of Tender Offers, Pricing, Election of Early Settlement and Increase in the Maximum Tender Offer Amount 2CVS Caremark Corporation Announces Early Results of Tender Offers, Pricing, Election of Early Settlement and Increase in the Maximum Tender Offer Amount 3CVS Caremark Corporation Announces Early Results of Tender Offers, Pricing, Election of Early Settlement and Increase in the Maximum Tender Offer Amount 4CVS Caremark Corporation Announces Early Results of Tender Offers, Pricing, Election of Early Settlement and Increase in the Maximum Tender Offer Amount 5CVS Caremark Corporation Announces Early Results of Tender Offers, Pricing, Election of Early Settlement and Increase in the Maximum Tender Offer Amount 6
... Pharmaceuticals announced that Richard Kent, M.D., a partner at ... directors.  Dr. Kent will replace Garheng Kong, M.D., Ph.D., ... Kong, who has recently taken a position as a ... chairman of the board. Dr. Kent brings ...
... Reportlinker.com announces that a new market research ... Active Pharmaceutical Ingredients (APIs) Market to ... Sector will Sustain Growth ... Ingredients (APIs) Market to 2015 - Rise in ...
Cached Medicine Technology:Cempra Pharmaceuticals Names Richard Kent, M.D., to Its Board of Directors 2Reportlinker Adds Active Pharmaceutical Ingredients (APIs) Market to 2015 - Rise in the Generic and Biotech Sector will Sustain Growth 2Reportlinker Adds Active Pharmaceutical Ingredients (APIs) Market to 2015 - Rise in the Generic and Biotech Sector will Sustain Growth 3Reportlinker Adds Active Pharmaceutical Ingredients (APIs) Market to 2015 - Rise in the Generic and Biotech Sector will Sustain Growth 4Reportlinker Adds Active Pharmaceutical Ingredients (APIs) Market to 2015 - Rise in the Generic and Biotech Sector will Sustain Growth 5Reportlinker Adds Active Pharmaceutical Ingredients (APIs) Market to 2015 - Rise in the Generic and Biotech Sector will Sustain Growth 6Reportlinker Adds Active Pharmaceutical Ingredients (APIs) Market to 2015 - Rise in the Generic and Biotech Sector will Sustain Growth 7Reportlinker Adds Active Pharmaceutical Ingredients (APIs) Market to 2015 - Rise in the Generic and Biotech Sector will Sustain Growth 8Reportlinker Adds Active Pharmaceutical Ingredients (APIs) Market to 2015 - Rise in the Generic and Biotech Sector will Sustain Growth 9Reportlinker Adds Active Pharmaceutical Ingredients (APIs) Market to 2015 - Rise in the Generic and Biotech Sector will Sustain Growth 10Reportlinker Adds Active Pharmaceutical Ingredients (APIs) Market to 2015 - Rise in the Generic and Biotech Sector will Sustain Growth 11Reportlinker Adds Active Pharmaceutical Ingredients (APIs) Market to 2015 - Rise in the Generic and Biotech Sector will Sustain Growth 12Reportlinker Adds Active Pharmaceutical Ingredients (APIs) Market to 2015 - Rise in the Generic and Biotech Sector will Sustain Growth 13Reportlinker Adds Active Pharmaceutical Ingredients (APIs) Market to 2015 - Rise in the Generic and Biotech Sector will Sustain Growth 14Reportlinker Adds Active Pharmaceutical Ingredients (APIs) Market to 2015 - Rise in the Generic and Biotech Sector will Sustain Growth 15Reportlinker Adds Active Pharmaceutical Ingredients (APIs) Market to 2015 - Rise in the Generic and Biotech Sector will Sustain Growth 16Reportlinker Adds Active Pharmaceutical Ingredients (APIs) Market to 2015 - Rise in the Generic and Biotech Sector will Sustain Growth 17
(Date:8/21/2014)... chronic kidney disease patients may be a strong indicator ... in the Journal of the American Society of ... Hopkins Bloomberg School of Public Health assert that coronary ... atherosclerosis in predicting the risk of heart disease among ... all patients with chronic kidney disease (CKD) die from ...
(Date:8/21/2014)... Health System and The University of Texas MD Anderson ... a new level of specialized breast screening at a ... Houston area. , Starting in late November, MD Anderson ... services for five of Memorial Hermann,s 10 breast care ... and Sugar Land. , Over time, the network will ...
(Date:8/21/2014)... only is eating better and exercising healthy for people with ... year, a new study finds. The study, led by ... Forest Baptist Medical Center in Winston-Salem, N.C., included more ... Participants ranged in age from 45 to 76, ... program" focused on diet and exercise, or to a standard ...
(Date:8/21/2014)... August 21, 2014 Transvaginal mesh ... Inc. continue to move forward in the federal ... District of West Virginia, Bernstein Liebhard LLP reports. ... 14th, the Court has established new stipulated evidence ... handling, division, storage and preservation. (In re C.R. ...
(Date:8/21/2014)... FRANCISCO Aug. 21, 2014 Researchers in the ... congenital cataracts can quickly and accurately diagnose a number ... a study published online today in ... Ophthalmology. Using a single test, doctors were able ... on their mutations reducing the time and money spent ...
Breaking Medicine News(10 mins):Health News:Measuring calcium buildup to predict heart disease in those with chronic kidney disease 2Health News:MD Anderson and Memorial Hermann to operate breast screening network across Houston area 2Health News:Getting Healthier a Big Money-Saver for People With Diabetes 2Health News:Transvaginal Mesh Lawsuits Move Forward in Federal C.R. Bard Litigation with Issuance of New Pretrial Order, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuits Move Forward in Federal C.R. Bard Litigation with Issuance of New Pretrial Order, Bernstein Liebhard LLP Reports 3Health News:New DNA test for diagnosing diseases linked to childhood blindness 2
... People who suffer cardiac arrests and then receive coronary ... brain damage compared with those who don,t have the ... School of Medicine researchers. The study, published in the ... Medicine and now available online, showed that patient ...
... March 31 Responding to negative impacts on clinician productivity and ... Inc. ( www.usercentric.com ) - a ... service offering specifically for health care organizations (HCOs) : ... clinicians are struggling to adopt EHRs because they are too time-consuming ...
... Research (IADR) announces Dr. Anthony Fauci, director, National Institute ... Institutes of Health in Bethesda, Md., USA as 2009 ... at the 87th General Session & Exhibition in Miami, ... Dr. Fauci became director of NIAID, where he oversees ...
... of Cosmetic Surgery 2008 Procedural Survey shows a 2% ... the first time in several years, male cosmetic surgery ... of Cosmetic Surgery (AACS), a leader in the cosmetic ... survey reveals that males are cutting back on cosmetic ...
... The not-for-profit LENA Foundation is putting forth a ... Society of Research in Child Development (SRCD). At the ... one poster will be presented based on findings using ... SRCD is a great opportunity for our colleagues to ...
... FRAMINGHAM, Mass., March 31 Courion(R) Corporation ... today announced that Kurt Johnson, vice president of corporate ... leader of technical management, will deliver a presentation entitled ... Compliance," at the HIMSS 09 Annual Conference ...
Cached Medicine News:Health News:Coronary angiography may improve outcomes for cardiac arrest patients 2Health News:Coronary angiography may improve outcomes for cardiac arrest patients 3Health News:User Centric to Address EHR Usability With New Service Offering 2Health News:User Centric to Address EHR Usability With New Service Offering 3Health News:Male Cosmetic Surgery Slows Down While Female Cosmetic Surgery Advances 2Health News:Five Research Studies at International SRCD Meeting in Denver Use Technology from Boulder Foundation 2Health News:Five Research Studies at International SRCD Meeting in Denver Use Technology from Boulder Foundation 3Health News:Courion and Alegent Health to Discuss HIPAA and Next-Generation Healthcare Portals at HIMSS 09 Annual Conference and Exhibition 2
...
...
... antimony pH catheters are designed for patient comfort ... catheters are number marked at 5cm intervals and ... sixteen individual models are available spanning most clinical ... multi-use models with one or two sensors., ...
... designed for patient comfort as well as dependable ... at 5cm intervals and line marked each centimeter., ... available spanning most clinical needs and the range ... or two sensors., ,A range of four ...
Medicine Products: