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NewGen Therapeutics Presents Data on NT-113, A Novel Pan-ErbB Inhibitor, at American Association of Cancer Research
Date:4/8/2013

1 brain/plasma concentrations)
  • Excellent oral bioavailability and pharmacokinetics
  • Potency against the distinct EGFR mutations found in both GBM and other solid tumors including extra-cranial malignancies such as NSCLC, breast cancer and melanoma
  • Demonstrated potent anti-cancer activity in an HER2 positive gastric cancer, T790M mutant NSCLC and GBM39 intracranial mouse xenograft studies
  • "These unique differentiating attributes have the potential to make NT-113 the preferred treatment for patients with malignancies that over-express members of the ErbB family, including GBM, NSCLC, breast cancer, gastric cancer, colon cancer, head and neck cancer, and melanoma," commented Harry D. Pedersen , President and Chief Executive Officer. "Over 90% of solid tumors over-express at least one ErbB receptor. Agents targeting single receptors in the family, including Iressa®, Herceptin®, Erbitux® and Tarceva®, have made a significant impact on survival in a number of cancers and account for billions of dollars in annual sales.  A single agent that targets all receptors in the family should result in better overall clinical outcomes."

    "Moreover, NT-113's remarkable ability to cross the blood brain barrier suggests it could be particularly beneficial to patients with GBM or brain metastases from susceptible primary cancer types. While current agents that target individual ErbB receptors have high clinical response rates and significant increases in survival, patients frequently progress with brain metastases.  Since no other currently approved ErbB inhibitors cross the blood brain barrier, NT-113 has the potential to be a major advancement in the treatment of cancers that over-express one of the ErbB receptors and tend to metastasis to the brain.  Our plan is to initially focus on GBM, where EGFR is a validated target and we have a chance for an accelerated approval wi
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    SOURCE NewGen Therapeutics
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