Navigation Links
NewGen Therapeutics Presents Data on NT-113, A Novel Pan-ErbB Inhibitor, at American Association of Cancer Research
Date:4/8/2013

1 brain/plasma concentrations)
  • Excellent oral bioavailability and pharmacokinetics
  • Potency against the distinct EGFR mutations found in both GBM and other solid tumors including extra-cranial malignancies such as NSCLC, breast cancer and melanoma
  • Demonstrated potent anti-cancer activity in an HER2 positive gastric cancer, T790M mutant NSCLC and GBM39 intracranial mouse xenograft studies
  • "These unique differentiating attributes have the potential to make NT-113 the preferred treatment for patients with malignancies that over-express members of the ErbB family, including GBM, NSCLC, breast cancer, gastric cancer, colon cancer, head and neck cancer, and melanoma," commented Harry D. Pedersen , President and Chief Executive Officer. "Over 90% of solid tumors over-express at least one ErbB receptor. Agents targeting single receptors in the family, including Iressa®, Herceptin®, Erbitux® and Tarceva®, have made a significant impact on survival in a number of cancers and account for billions of dollars in annual sales.  A single agent that targets all receptors in the family should result in better overall clinical outcomes."

    "Moreover, NT-113's remarkable ability to cross the blood brain barrier suggests it could be particularly beneficial to patients with GBM or brain metastases from susceptible primary cancer types. While current agents that target individual ErbB receptors have high clinical response rates and significant increases in survival, patients frequently progress with brain metastases.  Since no other currently approved ErbB inhibitors cross the blood brain barrier, NT-113 has the potential to be a major advancement in the treatment of cancers that over-express one of the ErbB receptors and tend to metastasis to the brain.  Our plan is to initially focus on GBM, where EGFR is a validated target and we have a chance for an accelerated approval wi
    '/>"/>

    SOURCE NewGen Therapeutics
    Copyright©2012 PR Newswire.
    All rights reserved

    Page: 1 2 3

    Related medicine technology :

    1. Cell Therapeutics, Inc. (CTI) to Report First Quarter Financial Results on April 20
    2. Faruqi & Faruqi, LLP Encourages Investors Who Suffered Substantial Losses Investing in Chelsea Therapeutics International, Ltd. to Contact the Firm
    3. Argos Therapeutics Secures $25 million Series D Financing to Commence Phase 3 ADAPT Study in Patients with Metastatic Renal Cell Carcinoma (mRCC) in Mid-2012
    4. Novelos Therapeutics Announces Successful Completion of First Cohort In Lung Cancer Trial With I-124-CLR1404 (LIGHT) Cancer-Targeted PET Imaging Agent at UW Carbone Cancer Center
    5. Zacks Industry Outlook Highlights: Eli Lilly, Forest Labs, ViroPharma, Novartis and United Therapeutics
    6. Oxford BioTherapeutics Appoints Senior Industry Leader to Head its New Clinical Development Operations in Basel, Switzerland
    7. Nektar Therapeutics Reports Financial Results for the First Quarter of 2012
    8. Cara Therapeutics Licenses Novel Kappa Opioid Agonist, CR845, to Chong Kun Dang Pharmaceutical Corporation For South Korean Market
    9. Frost & Sullivan: High Uptake of New Drug Therapies and Aging Population Expansion Keep the U.S. Retinal Therapeutics Market Buoyant
    10. Zenobia Therapeutics, Inc. And BioBlocks, Inc. Announce Sale Of A Joint Fragment Library Ideal For Screening By All Popular Methods
    11. New Forecast Shows Global Protein Therapeutics Market to Reach $143.4 Billion by 2015
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:1/15/2014)... YORK , January 15, 2014 ... Ltd., the exclusive worldwide distributor of highly sophisticated agro-breeding ... on January 7, 2014, the Company,s board of directors ... Weiner as its new member of the board. ...
    (Date:1/15/2014)... 15, 2014  In an unprecedented effort to curb the spread of ... other transport vehicles, an advanced and portable UV germicidal lamp manufactured ... first time. In order to prevent EMS paramedics ... West Palm Beach Fire Rescue is the ...
    (Date:1/15/2014)... R.I. , Jan. 15, 2014 MultiCell Technologies, ... filed a U.S. provisional patent application concerning composition of ... to achieve targeted tumor cell death.  ... small noncoding double stranded RNA molecules (VSRNAs) which interfere ...
    Breaking Medicine Technology:BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3Superbugs No Longer Ride In Rescue Vehicles 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3
    ... for Tuesday, December 9 at 11:00 am ET to Discuss ... , SOUTH SAN FRANCISCO, Calif., Dec. ... SNSS ), a biopharmaceutical company focused on the development and ... its studies of voreloxin in acute myeloid leukemia (AML) will ...
    ... 1 Vical Incorporated (Nasdaq: VICL ) announced ... Merck & Co., Inc. based on Merck,s planned initiation of ... (pDNA) cancer vaccine. The candidate vaccine is based on Vical,s ... (hTERT). hTERT is the subject of separate license agreement. , ...
    Cached Medicine Technology:Sunesis Announces New Data on Voreloxin for Acute Myeloid Leukemia To Be Presented at ASH 2Sunesis Announces New Data on Voreloxin for Acute Myeloid Leukemia To Be Presented at ASH 3Vical Receives Milestone Payment from Merck & Co., Inc. Triggered by Planned Initiation of Investigational Cancer DNA Vaccine Trial 2
    (Date:7/9/2014)... Chase Cancer Center paint a relatively optimistic picture of ... that have spread to the chest wall or skin, ... the skin, regardless of size and whether they have ... and called "locally advanced" tumors, suggesting that they ... poor survival. Locally advanced breast cancers of this and ...
    (Date:7/9/2014)... The Miriam Hospital have found that people with ... depressed have difficulty sticking to a pulmonary rehabilitation ... women, and screening and brief treatment of depression ... study and its findings are published in print ... obstructive pulmonary disease is a common and often ...
    (Date:7/9/2014)... July 9, 2014 There has been a sharp ... Southwestern Medical Center using MyChart, the online, interactive service ... communicate with their healthcare providers, schedule appointments, and renew ... patients actively using MyChart each year increased ... increased more than 10-fold, according to a study by ...
    (Date:7/9/2014)... is for more than watching World Cup highlights, Brian ... skateboarders landing in unfortunate positions on railings. A University ... Dermatology Online Journal shows that YouTube also allows ... the public on topics of skin cancer and prevention. ... is the future of how we communicate around the ...
    (Date:7/9/2014)... is one of the most important organs in the ... utilize our food properly this is its synthesis ... our organism this is its detoxification function. Lack ... food all damage the liver. The resulting diseased cells ... and life-threatening liver failure. According to the German Liver ...
    Breaking Medicine News(10 mins):Health News:Fox Chase researchers recommend updating the staging criteria for breast cancer diagnoses 2Health News:Fox Chase researchers recommend updating the staging criteria for breast cancer diagnoses 3Health News:Miriam Hospital study examines effect of depressed mood on pulmonary rehab completion 2Health News:MyChart use skyrocketing among cancer patients, UT Southwestern study finds 2Health News:MyChart use skyrocketing among cancer patients, UT Southwestern study finds 3Health News:Study of dermatology on YouTube shows new ways science reaches public 2Health News:Telemedicine for patients with chronic liver diseases 2Health News:Telemedicine for patients with chronic liver diseases 3
    ... always been stated time and again that smoking is injurious ... respiratory system. The effects of smoking may be understood by ... // lungs., ,Monoamine oxidase A (MAOA) is important in ... blood pressure. In a new study, researchers at the National ...
    ... disease which afflicts hundreds of elderly people may be a ... keep patients mentally agile and slow the crippling illness, say ... and not a normal process of ageing with phases of ... is past, the person slowly goes blank," N.M. Narula, president ...
    ... cancer is the most common cancer affecting men and occurs ... Men above the age of 50 years should undergo the ... // Prostate Specific Antigen, by monitoring the levels of PSA ... of the disease should begin regular prostate screening exams at ...
    ... published in the new issue of Archives of Facial ... with treatment procedures like laser therapy and other procedures. ... form an external birthmark and can be disfiguring, especially ... had presented the current treatment approaches for port-wine stains ...
    ... characterized by distorted, sickle shaped red blood cells. The disease ... the kidneys, spleen, and liver. The sickle cell disease is ... 1 in 500., ,Despite much clinical work, there is ... relieved, and the frequency and duration of the crises can ...
    ... San Francisco have found that eating five or more ... of pancreatic cancer by 50 per cent. ... were onions, garlic, beans, yellow vegetables (such as carrots, ... vegetables and cruciferous vegetables. Light-green vegetables, tomatoes and tomato ...
    Cached Medicine News:Health News:Active Lifestyle Helps To Slowdown Illness In Alzheimer's Patients 2Health News:Hydroxyurea Treatment For Children With Sickle Cell Disease 2
    ... The Sidekick Testing System is the smallest ... System is there when you need it ... or suitcase, or simply in your purse or ... take wherever you go. And, because it's so ...
    Inquire...
    Inquire...
    ... Tube is a cost-effective method of providing ... your patient. The warming tube is ideal ... Cath. Lab., and Radiology. The CSZ Warming ... warm patients since it may be used ...
    Medicine Products: