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NewGen Therapeutics Presents Data on NT-113, A Novel Pan-ErbB Inhibitor, at American Association of Cancer Research
Date:4/8/2013

MENLO PARK, Calif., April 8, 2013 /PRNewswire/ -- Preclinical data showing high potency, excellent pharmacokinetics and single-agent anti-cancer activity of NT-113, a novel irreversible Pan-ErbB Tyrosine Kinase Inhibitor under development by NewGen Therapeutics, was presented in a poster session today at the American Association of Cancer Research Meeting in Washington, D.C. 

(Logo: http://photos.prnewswire.com/prnh/20130408/SF90357LOGO)

Data showed that NT-113 is a very potent inhibitor of ErbB subtypes, including EGFR, HER2 and ErbB4, in a panel of over 100 tyrosine kinases and is highly active against erlotinib (Tarceva®) and gefitinib (Iressa®) resistant cancer cells with EGFR mutations including T790M, L858R, and d-746-750.  Potent anti-cancer activity was demonstrated in T790M mutant non-small cell lung (NSCLC) cancer and HER2 positive gastric cancer xenograft models. Pharmacokinetic data showed excellent oral bioavailability, a long half-life and the ability to penetrate the blood barrier at therapeutic concentrations.

In collaboration with C. David James , Ph.D., University of California, San Francisco (UCSF), NT-113 was studied for both in vitro and in vivo for activity in glioblastoma (GBM).  NT-113 showed a broad spectrum of in vitro activity across multiple human GBM cell lines. In addition, data showed statistically significant anti-cancer activity and increase in survival relative to a control group in an intracranial GBM39 mouse xenograft model. GBM39 is a human GBM cell line that carries the disease driving EGFRvIII mutation.

Key differentiating features of NT-113 include:

  • Equipotency across EGFR, HER2 and ErbB4
  • Excellent distribution of NT-113 into the brain at therapeutic doses (4:
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SOURCE NewGen Therapeutics
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