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New post-hoc analyses examined Neupro® effects on pain, depressed mood, apathy and fatigue in patients with Parkinson's disease
Date:4/26/2012

ing motor function and nocturnal sleep disturbance with rotigotine transdermal system.* Secondary efficacy measures in the RECOVER™ study were the Nocturnal, Akinesia, Dystonia and Cramps Score (NADCS) and exploratory outcome measures included the Likert Pain Scale.  

For the post-hoc analysis, baseline Likert pain scores (0=no pain up to 10 =worst pain experienced) were available for 267 patients (89 placebo, 178 rotigotine). Seventy percent of patients had a score greater than or equal to 1 (any pain) and of these, 47% scored 1-3 (mild pain), and 53% scored greater than or equal to 4 (moderate to severe pain).  

Improvements in pain were observed among patients with a score greater than or equal to 1 at baseline with a  treatment difference of -0.88 (p=0.0128), and in those with a score greater than or equal to 4 with a treatment difference of -1.38 (p=0.0117). Treatment difference in the 1-3 sub-group was -0.37,  (p=0.3756).

The Nocturnal Akinesia, Dystonia and Cramps Score (NADCS) was used to measure the severity of these symptoms, from 0 (normal) to 4 (maximal severity). In patients with a pain score greater than or equal to 1, improvements were observed with rotigotine transdermal system versus placebo in NADCS with a treatment difference of -0.54 (p=0.0275). Treatment differences for 1-3 and greater than or equal to 4 subgroups were -0.47 (p=0.1416), and -0.62 (p=0.0825).

*In SP513, PREFER, CLEOPATRA-PD and the RECOVER study patients received rotigotine transdermal system from 2-16 mg/24 hours. In the US the maximum recommended dosage of rotigotine transdermal system for patients with early-stage and advanced PD is 6 mg/24 hours and 8 mg/24 hours, respectively.

Notes to Editors

About Neupro® in the U.S.
Neupro® (Rotigotine Transdermal System) is indicated for the treatment of the sign
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