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New Survey Reveals Causes that May Affect Compliance with Local Estrogen Therapy
Date:5/8/2013

urveyed, 85 percent had used a vaginal cream, 9 percent had used the vaginal ring, and 6 percent had used both cream and the ring before switching to the vaginal tablet.3

"The survey may help healthcare professionals identify reasons for non-compliance with certain local estrogen therapy formulations, which emphasize the role that a patient's preference may play in the adherence to her treatment for vaginal atrophy," said lead author Mary Jane Minkin , MD, FACOG, clinical professor of obstetrics and gynecology at the Yale University School of Medicine.  "These insights serve as an effective argument that patient preference should be ascertained and help guide physicians' treatment selection for their patients."

Reasons for Non-compliance
The survey found that the majority of women (66 percent) who had previously used a cream reported they were "much more likely" to use the vaginal tablet compared to the cream.3  Of those who had previously used vaginal creams, many reported missing doses at least once a month.3  Reasons for non-compliance were mostly related to the formulation: messiness when filling and inserting the applicator (61 percent), general unpleasantness of the cream (53 percent), the need to wash the applicator (48 percent), and leakage of the cream following application (37 percent).3

The survey also found that 100 percent of the eight women who used the vaginal ring reported having delayed filling their prescriptions at some point during the course of their treatment due to formulation concerns such as difficulty removing the ring (50 percent) and ability of the patient or her partner to feel the ring (25 percent, each).3

The study did not evaluate non-compliance in patients using vaginal tablets because patients were currently on the medication at the time of the study.

Reasons for Switching 
The survey s
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SOURCE Novo Nordisk
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