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New Subset Analysis of AndroGel(R) Data Highlights Efficacy - Regardless of BMI
Date:6/17/2008

MARIETTA, Ga., June 17 /PRNewswire/ -- Solvay Pharmaceuticals, Inc. announced today that a new analysis of pivotal study data conducted by the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center showed that initial treatment response of hypogonadal men with AndroGel(R) (testosterone gel) 1% CIII had similar effects on subjects, regardless of weight and body mass index (BMI). These study results were presented today at the 2008 Endocrine Society Annual Meeting (ENDO) in San Francisco.

"Multiple studies have shown that obese men are at an increased risk of having low testosterone levels, so these new findings provide important insight into optimal treatment regimens for hypogonadal men," said Dr. Christina Wang, a study investigator at the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center. "However, despite the growing body of evidence surrounding the benefits of testosterone therapy for those who are hypogonadal, men are often unaware that the symptoms they are experiencing can be attributed to low testosterone and, therefore, are left undiagnosed and untreated."

The analysis presented is based on a new subset evaluation of a six-month safety and efficacy study of AndroGel published in 2000, from which researchers originally concluded that AndroGel was effective in restoring testosterone levels and in some cases, superior to a transdermal testosterone patch. In 2004, an additional follow-up, 36-month, open-label extension study was published that showed that AndroGel was safe for men to use over the long term.

Study Highlights

The study presented at ENDO examined the relationship between BMI and sex hormones in hypogonadal men both before and after treatment with testosterone. The study found:
-- Neither testosterone nor free testosterone is significantly related to

BMI either before or after testosterone treatment.

-- Testosterone treatment decreases SHBG more in l
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SOURCE Solvay Pharmaceuticals, Inc.
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