Navigation Links
New Subgroup Analysis of LUX-Lung 1 Trial Suggests Afatinib Increases Progression-Free Survival in Advanced Lung Cancer Patients More Likely to Have EGFR Mutations
Date:12/9/2010

f this study as we move toward personalized treatments," said principal investigator Vincent A. Miller, M.D., associate attending physician at Memorial Sloan Kettering Cancer Center, New York. "These data suggest that a certain subgroup of patients – those most likely to have EGFR mutations – may respond more positively with afatinib, and warrant further investigation."

As part of Boehringer Ingelheim's comprehensive and robust LUX clinical trial program, the phase III LUX-Lung 3 trial recently began to specifically investigate afatinib as a first-line treatment in patients with advanced NSCLC who have EGFR mutations.

About Afatinib

Afatinib is an investigational orally-administered irreversible inhibitor of both the EGFR and human epidermal receptor 2 (HER2) tyrosine kinases that is under development in several solid tumors including NSCLC, breast and head and neck cancer.  Afatinib is not approved by the FDA; its safety and efficacy have not been fully established.  

About Afatinib's Clinical Trial Program: LUX Trial Program

The LUX trial program is a comprehensive program that comprises more than 10 trials conducted across the globe, investigating afatinib in a variety of different solid tumor types, including NSCLC, breast and head and neck cancer.

LUX-Lung 1 was a phase IIb/III trial that investigated afatinib plus best supportive care (BSC) versus placebo plus BSC in NSCLC patients who were previously treated with first-line chemotherapy and first-generation EGFR-TKIs, erlotinib or gefitinib.

LUX-Lung 2 is a phase II trial evaluating afatinib in NSCLC patients with EGFR mutations, either treatment naïve or after one line of chemotherapy.

In two ongoing global phase III trials, LUX-Lung 3 and LUX-Lung 6, the efficacy and safety of afatinib is compared to standard chemotherapy for first-line treatment of NSCLC patients with EGFR mutations in different geographic
'/>"/>

SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Trubion Announces Preliminary Analysis of Phase IIb Results With TRU-015 in Rheumatoid Arthritis
2. Oncology Drugs Development Update - Worldwide Markets and Forecasts of Approved EGFr/HEr2 Inhibitors, Treatment Costs, Pathway Analysis, Current and Expanded Clinical Indications, and Novel Agents in Development
3. New Data From Large Safety Analysis of MYCAMINE Shows Favorable Clinical Safety Profile
4. Immtech Announces Interim Analysis in Phase III African Sleeping Sickness Trial
5. Analysis Shows Vernakalant Hydrochloride Injection Increases Conversion to Normal Heart Rhythm in Acute Atrial Fibrillation Patients Treated Within 48 Hours of Onset
6. New Analysis of Study Data Shows That Asacol(R) (Mesalamine) Delivers Rapid Symptom Relief for Ulcerative Colitis Patients
7. A Sociolinguistic Analysis of In-Office Dialogue Reveals Psychiatrists and Parents Have Significantly Different Perceptions on ADHD and Psychiatric Comorbidities
8. Favrille Provides Update on Timing of Analysis from Pivotal Phase 3 Clinical Trial; Reports Third Quarter 2007 Financial Results
9. Results Of VYVANSE(TM) (lisdexamfetamine dimesylate) Effect Size Analysis Presented at Major Scientific Meeting
10. Progen Presents Additional Analysis of Data from PI-88 Phase 2 Liver Cancer Study at American Association for the Study of Liver Diseases
11. Retrospective Analysis Finds That Initiation of Insulin Glargine in Patients With Type 2 Diabetes was Associated With a Lower Incidence Rate of Myocardial Infarction as Compared With NPH Insulin
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)...  Humberto C. Antunes,  Galderma  worldwide CEO, will receive a ... of Drugs in Dermatology (JDD) at the upcoming ... is January 17-20, 2014, at the Omni Orlando Resort at ChampionsGate ... The ODAC is a distinguished event that delivers a ...
(Date:1/15/2014)...  In an unprecedented effort to curb the spread of "superbugs" such ... vehicles, an advanced and portable UV germicidal lamp manufactured by MRSA-UV ... In order to prevent EMS paramedics and transport ... West Palm Beach Fire Rescue is the first in ...
(Date:1/15/2014)... Inc. (Nasdaq: ECTE ) ("Echo"), a medical ... non-invasive, wireless continuous glucose monitoring system, today announced that ... CEO of Echo Therapeutics, will present at "TEN", Noble ... Mr. Doman will make a corporate presentation to ...
Breaking Medicine Technology:Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 2Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 4Superbugs No Longer Ride In Rescue Vehicles 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 3
... 17 The following letter is being released ... , Dear Fellow Shareholders: , We are pleased to report to you ... ever. During this difficult time we were able to complete and validate ... being able to manufacture Multikine for the Phase III clinical trial.  We ...
... , RALEIGH, N.C. , Feb. ... training solutions for the pharmaceutical and biotech industry, today announced ... and Retail Pharmacy .  The courses, developed in partnership ... to the company,s Managed Markets Excellence® Series, a ...
Cached Medicine Technology:CEL-SCI Corporation Releases Letter to Shareholders 2CEL-SCI Corporation Releases Letter to Shareholders 3CEL-SCI Corporation Releases Letter to Shareholders 4CEL-SCI Corporation Releases Letter to Shareholders 5CEL-SCI Corporation Releases Letter to Shareholders 6Pharmaceutical Institute Launches New Training Resources Focused on Employers and Retail Pharmacy 2Pharmaceutical Institute Launches New Training Resources Focused on Employers and Retail Pharmacy 3
(Date:7/9/2014)... -- Researchers from The Miriam Hospital have found ... who are also depressed have difficulty sticking to ... particularly true for women, and screening and brief ... of treatment. The study and its findings are ... , Chronic obstructive pulmonary disease is a ...
(Date:7/9/2014)... world have been linked to an emerging fungal ... National Institute for Mathematical and Biological Synthesis (NIMBioS) ... , In a series of mathematical models, ... of internal organs in frogs, could cause extinction ... are exposed to the virus every few years, ...
(Date:7/9/2014)... A retrospective study conducted by researchers at Tufts University ... adults with intellectual and developmental disabilities, the likelihood of ... dental care increased. The findings, published in the July/August ... help improve interventions designed to address the oral health ... reviewed the dental records of 107 patients at one ...
(Date:7/9/2014)... dramatically in Western societies. One frequently cited reason is ... fewer infections than previous generations, thereby delaying maturation of ... Sahlgrenska Academy, University of Gothenburg, monitored children until the ... system in relation to allergic disease. All of the ... Region, half of them on farms that produced milk.,Lower ...
(Date:7/8/2014)... A team of clinicians from Plymouth, UK, and Sydney, ... 10th July Australia) launched ACEmobile - a free-to-use app ... , ACEmobile is the first of its kind; an ... tool provides support through the whole process, meaning more ... out this type of assessment. Designed by clinicians for ...
Breaking Medicine News(10 mins):Health News:Miriam Hospital study examines effect of depressed mood on pulmonary rehab completion 2Health News:Study predicts ranavirus as potential new culprit in amphibian extinctions 2Health News:Adults with special needs see gains, challenges with long term oral care 2Health News:Adults with special needs see gains, challenges with long term oral care 3Health News:New app widens opportunities for dementia assessments 2Health News:New app widens opportunities for dementia assessments 3
... Oct. 15 With the Centers for Disease Control and ... now spread throughout the United States, the American Red Cross ... or are taking care of someone who has the flu. ... person to person in droplets of coughs or sneezes, and ...
... 15 Americans without health insurance are one major illness ... research by the Kellogg School of Management at Northwestern University ... major health concern, such as heart disease, cancer or a ... in order to pay their medical expenses. , ...
... a Medical College of Georgia resident and faculty member may ... circumstances. About 2 percent of patients that undergo the ... performed in an emergency situation or prior to surgery. ... and uses a metal scope to open the mouth and ...
... Smoking bans are effective at reducing the risk of ... secondhand smoke, says a new report from the Institute ... sufficient evidence that breathing secondhand smoke boosts nonsmokers, risk ... even relatively brief exposures could lead to a heart ...
... Past President of the New Jersey Obstetrical and Gynecological Society ... 15 According to NAMS (North American Menopause Society), 6,000 ... a year. For the majority of women, hot flashes, ... For years, women have searched for a treatment that ...
... beautifully clear, acne-free skin, naturally? Skip the synthetics and ... Bees(®) Natural Acne Solutions(TM) products. , To view the ... , (Photo: http://www.newscom.com/cgi-bin/prnh/20091015/NY92770 ) ... truly natural* acne line clinically proven to help ...
Cached Medicine News:Health News:Red Cross Offers Important Tips for Caring for Someone With the Flu 2Health News:Red Cross Offers Important Tips for Caring for Someone With the Flu 3Health News:The Effects of Health on Wealth: New Study Reveals Individuals Without Health Insurance at Risk for 'Financial Catastrophe' 2Health News:The Effects of Health on Wealth: New Study Reveals Individuals Without Health Insurance at Risk for 'Financial Catastrophe' 3Health News:New laryngoscope could make difficult intubations easier 2Health News:Smoking bans reduce the risk of heart attacks associated with secondhand smoke 2Health News:On World Menopause Day, October 18, The International Menopause Society and World Health Organization Urge Women to Learn About Their Options for Dealing With Menopause 2Health News:On World Menopause Day, October 18, The International Menopause Society and World Health Organization Urge Women to Learn About Their Options for Dealing With Menopause 3Health News:Video: Introducing Natural Acne Solutions(TM) By Burt's Bees(R) 2
... The Aculens 186 UV combines the ... that include measurement of ultra violet transmission ... Velo 186 is also programmed to network ... other VELO Instruments, today, or in the ...
...
...
...
Medicine Products: