Navigation Links
New Subanalyses of the RE-LY Trial Showed Pradaxa Reduced Stroke Risk in Patients With Varying CHA2DS2-VASc Scores and Types of Non-Valvular Atrial Fibrillation
Date:4/4/2011

RIDGEFIELD, Conn., April 4, 2011 /PRNewswire/ -- Two new retrospective subanalyses of the RE-LY® trial, involving Pradaxa® (dabigatran etexilate mesylate) capsules, suggested that the reduction in stroke risk achieved with PRADAXA 150mg over warfarin (1) occurred irrespective of CHA2DS2-VASc risk score (2) and the type of non-valvular atrial fibrillation (NVAF) (permanent, persistent and paroxysmal)(3).  The results were presented at the American College of Cardiology's 60th Annual Scientific Session. (2,3)  

The first subanalysis assessed the impact of the novel CHA2DS2-VASc risk score,(2) which determines stroke risk based on age, sex and the presence of comorbidities,(4) on outcomes in the RE-LY trial.  Patients were grouped into quartiles based on CHA2DS2-VASc score (0-2, 3, 4, 5-9) (2) and results showed that PRADAXA 150mg was associated with reductions in stroke risk compared to warfarin for all four quartiles (0-2, RR = 0.63; 3, RR = 0.61; 4, RR = 0.53; 5-9, RR = 0.77; interaction p-value = 0.60).(2) Results of the analysis showed there was a significant interaction between CHA2DS2-VASc score and rates of major bleeding, with lower rates for PRADAXA 150mg compared to warfarin for patients in the first three quartiles, but an increased rate of major bleeding for the quartile at greatest risk (0-2, RR = 0.75; 3, RR = 0.74; 4, RR = 0.83; 5-9, RR = 1.33; interaction p-value = 0.003).(2)

"This analysis suggests that PRADAXA 150mg taken twice daily may reduce the risk of stroke compared to warfarin across the levels of NVAF-associated stroke risk, as determined by the CHA2DS2-VASc score," said Paul Reilly, Ph.D., clinical program director, Boehringer Ingelheim Pharmaceuticals, Inc.  "These findings are important because the risk of stroke in patients with NVAF increases significantly with the presence of comorbidities, such as diabetes or hypertension."

PRADAXA was also evaluated in a second RE-LY suban
'/>"/>

SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. New Sub-Analysis of RE-LY Trial Examines Pradaxa in Patients with Atrial Fibrillation Undergoing Cardioversion
2. New Analyses of Data From RE-LY Trial, Involving Oral Anticoagulant Pradaxa, to be Presented at American Heart Associations Scientific Sessions
3. Data Published in The Lancet Compare Dabigatran Etexilate to Dose-Adjusted Warfarin Across RE-LY® Trial Centers
4. Boehringer Ingelheim Announces Enrollment is Complete for the Largest Atrial Fibrillation Outcomes Trial - The RE-LY(TM) Study
5. Publication in SLEEP Journal Demonstrates Positive Results of Large Multi-Center Clinical Trial for Provent® Sleep Apnea Therapy
6. Regado Biosciences, Inc. Presents Results of the RADAR Phase 2b Clinical Trial of its REG1 Anticoagulation System
7. Boston Scientific ION™ Platinum Chromium Stent System Demonstrates Strong Performance in Analysis of PERSEUS and TAXUS ATLAS Clinical Trial Data
8. Analysis of Data Across Multiple Drug Eluting Stent Trials Reinforces Positive Clinical Performance of XIENCE V®
9. REMEDIAL II Results on PLC Systems RenalGuard® to be Presented at ACC 2011s Late Breaking Clinical Trial Session
10. Omeros Reports Outcome of Phase 3 Trials of OMS103HP
11. Conatus Pharmaceuticals Presents Results From a Phase 2 Clinical Trial of CTS-1027 in HCV Genotype 1 Null-Responders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/1/2015)... May 1, 2015   Intarcia Therapeutics, Inc. ... as Vice President, Human Resources, reporting directly to ... As a new key member of the senior leadership ... and Leadership Team to assure the Company advances its ... embeds its core values and its dynamic culture. Another ...
(Date:5/1/2015)... , May 1, 2015 Hitachi Chemical Diagnostics, ... States launch of the ExoComplete™ 96-Well Plate ... easy system for exosome collection to mRNA purification.  The ... Vesicles ("ISEV") Annual Meeting, April 23 – 26, 2015, ... are intended for research use only of molecular biology ...
(Date:5/1/2015)... , May 1, 2015 Following yesterday,s release of ... D, here are five things you need to know: ... market-based structure is unique among government programs. ... D is different than other parts of Medicare and other ... that submit bids to offer prescription drug benefits to enrollees. ...
Breaking Medicine Technology:Intarcia Appoints James P. Brady Vice President, Human Resources 2Intarcia Appoints James P. Brady Vice President, Human Resources 3Intarcia Appoints James P. Brady Vice President, Human Resources 4New Products for Exosome Isolation to mRNA Purification 25 Things to Know About the CMS Part D Data Release 25 Things to Know About the CMS Part D Data Release 3
(Date:5/2/2015)... “ ActOn ” was featured on NewsWatch ... at the latest and coolest applications on the market for ... and technology expert, conducted the app review and shared with ... organizations to make a difference. , In this material world, ... that aren’t about money, which is why those things should ...
(Date:5/2/2015)... May 02, 2015 It’s a pattern ... natural disaster strikes anywhere on this planet, cyber scammers ... sympathy and compassion for their own personal gain. ... Emergency Readiness Team) issued an alert titled “Nepal ... email scams citing the earthquake in Nepal. The scam ...
(Date:5/2/2015)... “ Peachtree Audio ” was featured on ... features the latest and coolest technology products available to ... for NewsWatch, conducted the review and shared with viewers ... Music is an important part of people’s lives – ... the royal treatment. Peachtree Audio does just that with ...
(Date:5/2/2015)... Chicago, IL (PRWEB) May 02, 2015 Kare ... to provide support for busy caregivers. Kare Visits offers ... hospitals, and assisted living facilities. According to the ... caregivers spend an average of 20 hours a week caring ... fraction of the cost to hire a nurse, a caregiver ...
(Date:5/2/2015)... 2015 ZoomCare, the Portland-based innovator of ... to offer its new healthcare insurance to individuals and ... Health Insurance System is the nation’s first health insurance ... performance. ZOOM+ Personal Health Insurance was ZoomCare’s first such ... are subject to review and regulation by the Oregon ...
Breaking Medicine News(10 mins):Health News:An Application to Help People Make a Difference Was Featured on NewsWatch Television 2Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 2Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 3Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 4Health News:Affordable High-End Audio Equipment was Featured on NewsWatch Television 2Health News:Chicagoan Seeks to Transform Industry by Launching an Innovative Elderly Care Solution 2Health News:ZoomCare Applies to be on Oregon Exchange 2
... Penn State researchers shows that diets focusing on foods that are ... people to control hunger. ,Foods that are high ... soup, lean meat, and low-fat dairy products are low in ... ,Eating a diet that is low in calorie density allows people ...
... to enter rehab for treatment for alcoholism. ... 'Bon Jovi' has revealed the news, albeit without naming the ... facility in Los Angeles. He asks that you respect he ... the representative as saying. ,The magazine also reported ...
... fever, a devastating pig disease that could also threaten ... Friday. ,"This is a dramatic development," said ... FAO, noting that the highly contagious viral disease "has ... ,Armenia, Azerbaidjan and Russia "should be on ...
... deadly H5N1 bird flu virus in Hong Kong, agricultural officials ... the bird, found dead last week in the rural New ... ,They warned of personal contact with wild birds and live ... found dead in Hong Kong this year with H5N1, which ...
... on foods that are low in calorie density can promote healthy ... ,Foods that are high in water and low in fat ... are low in calorie density and provide few calories per ... calorie density allows people to eat satisfying portions of food, and ...
... Exhausted, stressed out and thinner than she used to be, ... life this week, and she's not even 18 yet . ... hopefuls struggling through China's university placement exams, a pressure-packed, make-or-break ... or trap her down in the faceless masses. ...
Cached Medicine News:Health News:Eating Smartly- A Key to Lose Weight 2Health News:Low Calorie Diet can Promote Healthy Weight Loss and Help Control Hunger 2Health News:Make-or-break Exams Stress China Youth 2Health News:Make-or-break Exams Stress China Youth 3
Pediatric: Binocular Balance, Tumbling "E" Monocular Acuity, Binocular Acuity, Fixation Disparity, Stereopsis...
Multi-Acuity: Letter Acuity, Tumbling E,and Allen Tests....
... antigen (PSA) is a serine protease that ... epithelial cells of the,acini and ducts. Normal ... 0.1-2.6 ng/ml. Reports have suggested that elevated,level ... the must useful tumor,markers in diagnosis of ...
Designed specifically for use with children ages,3 and up The patient is asked to distinguish between a "Raised E" and a non stereo target....
Medicine Products: