Navigation Links
New Study Suggests Tapentadol IR for Acute Pain Is Associated With Improved Gastrointestinal Tolerability Compared to Oxycodone IR
Date:5/9/2008

The most common treatment emergent adverse events for both groups were nausea, vomiting, dizziness, constipation, headache, and somnolence (drowsiness). While the incidence of nausea, vomiting, constipation and the composite nausea and vomiting were significantly lower in the tapentadol IR treated groups compared to the oxycodone IR groups, the incidences of dizziness and somnolence (drowsiness) were not significantly different between the treatment groups.

"Gastrointestinal side effects, such as constipation, from centrally acting opioid pain medicines can be a treatment complication for pain patients and their healthcare professionals," said David Upmalis, M.D., Senior Director, CNS/Pain, J&JPRD. "Our study shows that tapentadol IR may offer improved gastrointestinal tolerability compared to other strong pain medications. Such a difference could improve patient treatment, and provide healthcare professionals an additional therapeutic option to treat acute pain."

Tapentadol is a novel investigational, centrally acting oral analgesic. It has a unique profile with two mechanisms of action, combining mu-opioid receptor agonism and norepinephrine reuptake inhibition in a single molecule. It is being developed in immediate-release formulation for acute pain and extended-release formulation for chronic pain.

The use of tapentadol IR for the treatment of moderate to severe acute pain is under review by the United States Food and Drug Administration. The New Drug Application (NDA) was filed on January 23, 2008. Upon FDA approval, PriCara(TM), Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc., will market tapentadol in the United States. The NDA filing is part of the ongoing commitment of J&JPRD and PriCara(TM) to bring new and innovative products to patients and physicians for the treatment and management of pain.

Study Design

This Phase 3, double-blind, randomized, active-control, parallel group, multi-center trial of 878 pa
'/>"/>

SOURCE Johnson & Johnson Pharmaceutical Research & Development,L.L.C.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. New Data From Phase 3 Study Suggests Tapentadol Immediate Release Effective for Acute Pain From Common Foot Surgery
2. New Study Demonstrates ACTEMRA(R) (tocilizumab) Inhibits Progression of Joint Damage in Rheumatoid Arthritis Patients
3. Results of the Phase III Pivotal Study of VYVANSE(TM) (Lisdexamfetamine Dimesylate) for the Treatment of ADHD in Adults Presented at National Scientific Meeting of Psychiatrists
4. Skin Flaps Deliver Cancer-fighting Therapy, ASPS Study Reveals
5. Data from Randomized Pilot Study, Real-World Use of OrbusNeichs Genous(TM) Bio-engineered R stent(TM) to be Presented in Symposium at EuroPCR 2008
6. Bayer and Regeneron Dose First Patient in Second Phase 3 Study for VEGF Trap-Eye in Wet Age-Related Macular Degeneration
7. Trubion Announces Initiation of Phase 2b Study of TRU-015 for the Treatment of Rheumatoid Arthritis
8. Study Demonstrates Lexapro(R) Significantly Improves Depression Symptoms in Adolescents
9. Patients Treated with Risperidone Long-Acting Injection had a Significantly Longer Time to Relapse Compared to Quetiapine in International Clinical Study
10. PEAK Surgical Announces Positive Results From Preclinical Study of PEAK PlasmaBlade(TM) for Obstetric and Gynecologic Surgery
11. New Study Confirms Dose-Accuracy of SoloSTAR(R) Prefilled Insulin Pen
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)...   MedeAnalytics today unveils Revenue Integrity, ... visibility to a provider,s "mid-cycle" to optimize revenue ... Powered by the industry,s leading big data platform, ... between patient access and the business office where ... revenue capture, minimize audit risk and prepare providers ...
(Date:9/17/2014)... --  myMatrixx, a pharmacy and ancillary medical benefit manager for workers, ... has awarded myMatrixx with a "Best Places to Work ... row. Best Places to Work is ... Best Companies Group.  The competition, which involves months of ... insurance industry companies with at least 25 employees in ...
(Date:9/17/2014)... MADISON, Tenn. , Sept. 17, 2014 ... be; these infections are not only uncomfortable, they,re often ... best-laid social plans. pH-D Feminine Health Support ( http://ph-defense.com ... vaginal health. It is an all-natural, homeopathic product. ... the most common symptoms of vaginal infection. In many ...
Breaking Medicine Technology:MedeAnalytics Unveils New Revenue Integrity Solution to Support the Transition to Value-Based Healthcare 2MedeAnalytics Unveils New Revenue Integrity Solution to Support the Transition to Value-Based Healthcare 3myMatrixx Honored with "Best Places to Work in Insurance" Award 2New Product from Vireo Systems: pH-D Feminine Health Support 2
... FRANCISCO, Calif., Aug. 25, 2011 Rigel Pharmaceuticals, Inc. ... M. Gower, chairman and chief executive officer, and Ryan ... Rigel, will present at two separate investor conferences in ... Healthcare Conference 2011Date: Thursday, September 8th at 10:20 a.m. ...
... Nutrastar International Inc. (OTCBB: NUIN; "Nutrastar" or the "Company"), ... Chinese Medicine ("TCM") consumer products, today announced that its ... under which Nutrastar may repurchase up to US$5 million ... 12 months. Under the program, the ...
Cached Medicine Technology:Nutrastar Announces Adoption of Share Repurchase Program 2Nutrastar Announces Adoption of Share Repurchase Program 3
(Date:9/18/2014)... Lake City, Utah (PRWEB) September 18, 2014 ... Now Spoonful of Comfort, an online food delivery service provider, ... , New Country Fresh Tomato Basil soup is a nod ... begins, of course, with a tangy tomato base, then Spoonful ... asiago and parmesan cheeses. A flashback to childhood has never ...
(Date:9/18/2014)... 2014 Computer Resources of America, Inc. ... New York City, has been awarded a contract to ... retailer with stores in over 150 countries. The services ... CRA being the retailer’s dispatch arm handling all IT ... Ramnarayan, Chief Executive Officer of CRA said, “We are ...
(Date:9/18/2014)... NY (PRWEB) September 18, 2014 ... which have special functions of adjusting human body ... have won great popularity with a variety of ... health food in China reached RMB187.4 billion, up ... 22.1% during 2006-2013. , View Full Report at ...
(Date:9/18/2014)... MA (PRWEB) September 18, 2014 ... its team and surgeon partners in Less Exposure ... joining SpineFrontier, Tamara authored an extensive education curriculum ... a Masters in Science in Organizational Leadership, and ... industries for eleven years. Bringing her to the ...
(Date:9/18/2014)... Dr. Suzaunna Clark, Psychologist, Life Coach and ... has to be seen to be believed and 2- ... to be used. Together, both lead to hearts that ... to do both. , Dr. Clark offers ... Hearts system, which provides professional guidance on dealing with ...
Breaking Medicine News(10 mins):Health News:An Old Classic Brings New Soup Delivery Options to Spoonful of Comfort 2Health News:CRA Awarded Managed Support Contract for Global Retailer 2Health News:China Health Food Industry Size 2014 Market Analysis, Growth, Trends and Forecast Report 2017: MarketResearchReports.biz 2Health News:China Health Food Industry Size 2014 Market Analysis, Growth, Trends and Forecast Report 2017: MarketResearchReports.biz 3Health News:China Health Food Industry Size 2014 Market Analysis, Growth, Trends and Forecast Report 2017: MarketResearchReports.biz 4Health News:SpineFrontier Inc. Makes Bold Move to Expand Its Internal Training Team to Collaborate With The LESSociety’s Less Exposure Surgery® University To Educate Surgeons. 2Health News:Suzaunna-Where Life! Happens Announces the Launch of Healing Hearts 2Health News:Suzaunna-Where Life! Happens Announces the Launch of Healing Hearts 3
... June 11 Orexigen(R) Therapeutics, Inc. (Nasdaq: ... of obesity, today announced the licensing of certain intellectual ... IP position underlying Contrave, its lead product candidate for ... agreement with GSK complements the IP foundation of Contrave, ...
... - Members of Congress Seek to Stem Growing Healthcare Coverage Shortfalls ... has introduced a bill, S. 1221, "The Medicare Prompt Pay ... introduced in the U.S. House of Representatives and currently has 45 ... Senators Arlen Specter (D-PA) and Pat Roberts (R-KS). The bill is ...
... WASHINGTON, June 11 A call for participants ... a national certification for medical interpreters. The National ... as an independent 501(c)3 non-profit certification entity, will ... ensure that the certification process is credible, transparent, ...
... Pharmaceuticals, Inc. (Nasdaq: TSPT ) announced today that ... company that it should expect to receive formal notice of ... new drug application (NDA) for Intermezzo (R) (zolpidem tartrate ... assigned a Prescription Drug User Fee Act (PDUFA) date of ...
... Help Grieving Children and Families , , CAMP HILL, ... 185 volunteers on Monday, June 15 at the Radisson Penn ... 6,500 hours - an average of nearly 35 hours each ... adolescents and their families at the Caring Place facility in ...
... Canada, June 11 Xenon today announced a strategic ... to discover and develop novel small molecule candidates for ... "We are very excited to be collaborating with Merck ... diseases," said Simon Pimstone, President and CEO of Xenon. ...
Cached Medicine News:Health News:Orexigen(R) Therapeutics Announces In-Licensing of Key Patents to Further Strengthen its Intellectual Property Estate for Contrave(R) 2Health News:Orexigen(R) Therapeutics Announces In-Licensing of Key Patents to Further Strengthen its Intellectual Property Estate for Contrave(R) 3Health News:Senate Bill to Protect Patients' Healthcare by Amending Medicare Coverage 2Health News:Senate Bill to Protect Patients' Healthcare by Amending Medicare Coverage 3Health News:Public Call for Participation on National Board of Certification for Medical Interpreters 2Health News:Public Call for Participation on National Board of Certification for Medical Interpreters 3Health News:Transcept Pharmaceuticals Announces Expected FDA Extension of Regulatory Review Period for Intermezzo(R) 2Health News:Transcept Pharmaceuticals Announces Expected FDA Extension of Regulatory Review Period for Intermezzo(R) 3Health News:Transcept Pharmaceuticals Announces Expected FDA Extension of Regulatory Review Period for Intermezzo(R) 4Health News:Highmark Caring Place To Honor Midstate Volunteers 2Health News:Highmark Caring Place To Honor Midstate Volunteers 3Health News:Xenon Enters Cardiovascular Disease Collaboration With Merck & Co., Inc. 2
... The Leica TP1020 product family are ... a perfect combination of approved technology with ... processing and maximum safety for tissues at ... engineering design based on proven precision mechanics ...
The HMP300 Histo Pro delivers all the features and benefits that conventional tissue processing have to offer....
... electronic, motorized rotary microtomes ... applications of paraffin, semi-thin ... specimens in clinical, research, ... instruments display extra-ordinary ergonomic ...
... RM2235 is a robust rotary microtome ... biological specimens embedded in paraffin. The ... micrometer feed system ensures premium quality ... sectioning harder tissues. The RM2235 is ...
Medicine Products: