Navigation Links
New Study Suggests Tapentadol IR for Acute Pain Is Associated With Improved Gastrointestinal Tolerability Compared to Oxycodone IR
Date:5/9/2008

TAMPA, Fla., May 9 /PRNewswire-USNewswire/ -- Many strong acting pain medications have bothersome side effects. These can include nausea and vomiting with short-term use, and constipation with longer, chronic use. Such symptoms can lead patients to discontinue treatment, adding additional complications to pain management for physicians. The novel investigational medication tapentadol, a centrally acting oral analgesic, provided pain relief for patients with fewer gastrointestinal side effects than those treated with an older, prescription pain reliever, researchers announced today.

Data from a new Phase 3 clinical study of tapentadol immediate release (IR) tablets demonstrated that tapentadol has a significantly improved gastrointestinal tolerability compared with oxycodone IR for treatment of acute pain and was well-tolerated when taken for up to 90 days.

These new data are being presented today in a poster session at the 27th Annual Scientific Meeting of the American Pain Society (APS) in Tampa, Florida. Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (J&JPRD), Raritan, NJ, supported this study and its presentation.

In this study, patients with low back pain or pain from osteoarthritis of the knee or hip were treated with a flexible dose of 50 mg or 100 mg of tapentadol IR every four to six hours, up to a maximum of 600 mg/day, or a flexible dose of 10 mg or 15 mg of oxycodone IR every four to six hours, up to a maximum of 90 mg/day; patients were treated for up to 90 days. While both tapentadol IR and oxycodone IR offered pain relief, the tapentadol IR treatment group experienced a statistically significantly lower incidence of nausea, vomiting, constipation and composite nausea/vomiting (P<0.001) for all treatment comparisons. Overall, the percentage of patients with treatment emergent adverse events in the tapentadol IR group, at 76 percent, was lower than the percentage in the oxycodone IR group at 83 percent.
'/>"/>

SOURCE Johnson & Johnson Pharmaceutical Research & Development,L.L.C.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. New Data From Phase 3 Study Suggests Tapentadol Immediate Release Effective for Acute Pain From Common Foot Surgery
2. New Study Demonstrates ACTEMRA(R) (tocilizumab) Inhibits Progression of Joint Damage in Rheumatoid Arthritis Patients
3. Results of the Phase III Pivotal Study of VYVANSE(TM) (Lisdexamfetamine Dimesylate) for the Treatment of ADHD in Adults Presented at National Scientific Meeting of Psychiatrists
4. Skin Flaps Deliver Cancer-fighting Therapy, ASPS Study Reveals
5. Data from Randomized Pilot Study, Real-World Use of OrbusNeichs Genous(TM) Bio-engineered R stent(TM) to be Presented in Symposium at EuroPCR 2008
6. Bayer and Regeneron Dose First Patient in Second Phase 3 Study for VEGF Trap-Eye in Wet Age-Related Macular Degeneration
7. Trubion Announces Initiation of Phase 2b Study of TRU-015 for the Treatment of Rheumatoid Arthritis
8. Study Demonstrates Lexapro(R) Significantly Improves Depression Symptoms in Adolescents
9. Patients Treated with Risperidone Long-Acting Injection had a Significantly Longer Time to Relapse Compared to Quetiapine in International Clinical Study
10. PEAK Surgical Announces Positive Results From Preclinical Study of PEAK PlasmaBlade(TM) for Obstetric and Gynecologic Surgery
11. New Study Confirms Dose-Accuracy of SoloSTAR(R) Prefilled Insulin Pen
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... CLEVELAND , Jan. 22, 2015  ViewRay™, a privately ... entered into an exclusive distributor agreement with ITOCHU Corporation ... radiation therapy system for the treatment of cancer in ... (me-rid-i-an) system, is the world,s first and only MRI-guided ...
(Date:1/22/2015)... OAKS, Calif. , Jan. 22, 2015  Amgen (NASDAQ: ... and full year 2014 financial results on Tuesday, Jan. 27, 2015, ... be followed by a conference call with the investment community at ... Robert A. Bradway , chairman and chief executive officer, and ...
(Date:1/22/2015)... Research and Markets ( http://www.researchandmarkets.com/research/x3hp3g/microbiology ) ... Testing/Clinical Microbiology Market by Product, Clinical Application & ... report to their offering. Clinical microbiology ... the detection of infectious diseases. The respiratory diseases ...
Breaking Medicine Technology:ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2Global Microbiology Testing/Clinical Microbiology (Instrument, Analyzer, Incubator, Kit, Microscope, Molecular Diagnostics) Market - Forecast to 2019 2Global Microbiology Testing/Clinical Microbiology (Instrument, Analyzer, Incubator, Kit, Microscope, Molecular Diagnostics) Market - Forecast to 2019 3
... Minn., Nov. 17, 2010 People who are searching ... with less potential for flushing can turn to Slo-Niacin®. ... Slo-Niacin® is a niacin supplement that has been shown ... "Slo-Niacin® features a unique patented polygel® system ...
... Sutro Biopharma today announced that the company has ... financing will support the company,s ongoing development of ... the company,s biochemical protein synthesis platform to meet ... Led by Skyline Ventures, the financing round, ...
Cached Medicine Technology:Slo-Niacin® Dietary Supplement Shown to Support 'Good' Cholesterol (HDL) 2Slo-Niacin® Dietary Supplement Shown to Support 'Good' Cholesterol (HDL) 3Slo-Niacin® Dietary Supplement Shown to Support 'Good' Cholesterol (HDL) 4Sutro Biopharma Secures $36.5 Million in Series C Financing 2
(Date:1/22/2015)... The Incredible Bulk is a revolutionary method put ... muscle by up to 30lbs in less than 12 weeks ... Stan Stevenson, prompting an investigative review. , “Our Incredible ... diet formula that allows the body to pack on a ...
(Date:1/22/2015)... AngelWeddingDress, the premier women’s dress supplier, has ... View website of AngelWeddingDress.com to find more ... dresses online for a bridal party. AngelWeddingDress offers a ... them. Its maternity wedding dresses are specially designed for ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 A new ... of experience and person-centeredness in the long-term care environment ... action across the continuum. The paper, “The Power of ... engages perspectives and practices of the patient, resident and ...
(Date:1/22/2015)... Oceanside,CA (PRWEB) January 22, 2015 For over 20 ... the Oceanside and Vista area has treated just about ... other personal injury circumstances. And for those same twenty-plus years, ... victims of all those injuries with the best possible doctor. ...
(Date:1/22/2015)... January 22, 2015 A study ... Medicine flagship journal Medicine & Science in Sports ... exercise may help reduce gastrointestinal (GI) problems associated ... , Participants in the double-blind, placebo-controlled study took ...
Breaking Medicine News(10 mins):Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3
... decided to join hands with the University of Auckland, //New ... combination or “polypills” to prevent strokes and heart attacks. ... and two drugs to prevent hypertension. The trial will check ... and its effectiveness when consumed as one pill. ,Investments ...
... drug for multiple complaints like cholesterol, blood pressure and ... Hyderabad-based laboratory//. ,Pharmacists at Dr Reddy’s have ... a cholesterol-lowering statin, two blood-pressure medicines, and blood-thinning aspirin. ... disease and stroke by 60 per cent. It will ...
... Femcon Fe, has hit pharmacy shelves. Femcon Fe, contains ... convenient in that it offers an option for women ... them, and those who dislike swallowing pills, according to ... of Rockaway, N.J. ,This product targets young ...
... we find a combination of healthy and tasty when we dine ... of low calorie foods//. ,Mostly we don’t get an indication ... depend on the chef for this piece of information, it is ... ,There is a revolution beginning world wide as people are ...
... spraying of Agent Orange and many other herbicides at a ... are in direct contact with the spray, for instance people ... to long term health risks, due to the presence of ... a series of scientific reports, communicating potential health risks due ...
... Those breast cancer patients who are still young, and ... for the stipulated //two years, post-treatment, to plan a ... patients were advised to wait for two years before ... not mandatory. ,Angela Ives of the University ...
Cached Medicine News:Health News:A Combined Heart Pill-developed by Dr. Reddy’ 2Health News:Poly-pill – A Single Drug For Multiple Complaint 2Health News:Are You Health-Conscious or Tongue- Conscious? 2
... visualization of the spine. Comfortable ... are provided for all body ... arms in both superior and ... can be positioned for a ...
High temperature loop tip cautery....
Thru cut kerrison style punch 30 deg, 2.75 X 1.4 mm cut, 110 working length....
Aaron 2250 is a multipurpose electrosurgical generator with monoploar and bi-polar functions....
Medicine Products: