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New Study Showed Lantus(R) Plus One, Two or Three Shots of Apidra(R) Lowered Patients' Blood Sugar
Date:6/6/2009

"By combining basal insulin Lantus(R) plus Apidra(R) mealtime insulin at one, two or three meals throughout the day, we observed A1C reductions with many patients achieving the target A1C of less than 7 percent," stated Mayer Davidson, M.D., Professor of Medicine, UCLA School of Medicine, Los Angeles, California.

From a mean A1C of 9.8% at minus week 14, A1C decreased by 2.5%, with 37% of patients reaching A1C<7% at the end of the run-in period. Patients not at goal (n=343) were randomized to 24 weeks of treatment.

Baseline characteristics were comparable among the 3 arms: 50% female, 63% white, age 53 years, weight 106 kg, BMI 37 kg/m squared, A1C 7.9%, FPG 120 mg/dl, and diabetes duration of 10 years.

In all groups, A1C improved from baseline to week 24. The percentage of patients achieving A1C<7% at week 24 was greater in the group receiving Apidra(R) three times daily (45.1%) versus the group receiving Apidra(R) one time daily (29.7%, P=0.017) and the group receiving Apidra(R) two times daily (33.3%, P=0.045) in the modified intent to treat population.

About Diabetes

Diabetes is a chronic, widespread condition in which the body does not produce or properly use insulin, the hormone needed to transport glucose (sugar) from the blood into the cells of the body for energy. More than 230 million people worldwide are living with the disease and this number is expected to rise to a staggering 350 million within 20 years. It is estimated that nearly 24 million Americans have diabetes, including an estimated 5.7 million who remain undiagnosed. At the same time, approximately 40 percent of those diagnosed are not achieving the blood sugar control target of A1C <7 percent recommended by the ADA. The A1C test measures average blood glucose levels over the past two- to three-month period.

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