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New Study Reveals Proprietary Saw Palmetto Extract (SPET-085) Supplement Can Effectively Inhibit the Enzyme Linked to Benign Prostatic Hyperplasia (BPH)
Date:7/12/2010

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While finasteride is currently the most common treatment for BPH, SPEs provide a more natural phytotherapeutic alternative to manage symptoms of the condition. There are many types of SPEs available today, based on a variety of extraction processes.  This study demonstrates that the approach to extraction may impact levels of BPH-related bioactivity among the various extracts of saw palmetto.

"The results of this study verify the high activity of our novel saw palmetto extract, SPET-085, to help maintain healthy prostate function," said Joe Veilleux, General Manager, Euromed USA. "Euromed is committed to ongoing clinical research to provide scientific evidence which will differentiate SPET-085 from other saw palmetto extracts."

About the Study

The nicotinamide adenine dinculeotide phosphate (NADPH)-dependent membrane protein 5alpha-reductase irreversibly catalyses the conversion of testosterone to the most potent androgen, 5alpha-dihydrotestosterone (DHT).  In humans, two 5alpha-reductase isoenzymes are expressed: type I and type II. Type II is found primarily in prostate tissue. Saw palmetto extract (SPE) has been widely used for the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia (BPH). The mechanisms of the pharmacological effects of SPE include the inhibition 5alpha-reductase, among other actions. Clinical studies of SPE have been equivocal, with some showing significant results and others not. These inconsistent results may be due, in part, to varying bioactivities of the SPE used in the studies.

The aim of the present study was to determine the in vitro potency of a novel saw palmetto ethanol extract (SPET-085) an inhibitor of the 5alpha-reductase isoenzyme type II, in a cell-free test system. On the basis of the enzym
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SOURCE Euromed
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