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New Study Published in New England Journal of Medicine Shows Investigational BIBF 1120 Demonstrated Positive Trend in Reducing Lung Function Loss in Idiopathic Pulmonary Fibrosis
Date:9/21/2011

011 and at a BI-sponsored symposium on Monday, Sept. 26, 2011. Key presentations include:

  • Efficacy of BIBF 1120 in patients with IPF is dose-dependent: results from the TOMORROW trial (Sunday, Sept. 25, 2011, 8:30-8:45 a.m. CEST)
  • Effect of baseline FVC on preservation of lung function with BIBF 1120: results from the TOMORROW trial (Sunday, Sept. 25, 2011, 8:45-9 a.m. CEST)
  • Presentation of the NEJM TOMORROW paper; Efficacy of a tyrosine kinase inhibitor in idiopathic pulmonary fibrosis at the ERS/NEJM "Late Breaking Research Session" (Monday, Sept. 26, 2011, 1:18-1:36 p.m. CEST)
  • Satellite symposium: Idiopathic Pulmonary Fibrosis: Evolutions in Diagnosis and Treatment  (Monday, Sept. 26, 2011, 5:15-7:15 p.m. CEST)

About the TOMORROW Trial

The phase II TOMORROW trial was a 12-month, randomized, double-blind, placebo-controlled trial conducted at 92 sites in 25 countries. The trial evaluated the safety and efficacy of oral BIBF 1120 at four dosage levels in reducing decline in lung function measured by FVC among 432 patients diagnosed with IPF, as defined by the American Thoracic Society (ATS) and ERS.

The primary endpoint for the TOMORROW trial was annual rate of decline in FVC. Secondary endpoints included acute exacerbations, quality of life using the SGRQ and total lung capacity.

About BIBF 1120

BIBF 1120 is an investigational small molecule tyrosine kinase inhibitor (TKI) in development by Boehringer Ingelheim for idiopathic pulmonary fibrosis (IPF). It targets three growth factors: the vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet-derived growth factor receptor (PDGFR). These receptors have been shown to be potentially involved in pathomechanisms of pulmonary fibrosis. By blocking these signaling pathways that are inv
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SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.
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