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New Study Points to Novel Mechanism by Which Tumors Escape Recognition by the Immune System
Date:11/29/2011

pes because MDSC activity has been shown in numerous cancers, including pancreatic cancer, breast cancer, lung cancer and melanoma.

Commenting on the study results, Dr. Gabrilovich said, "Our study not only demonstrated a novel mechanism by which the tumor escapes recognition by the immune system but also suggested a potential approach to its correction, which may improve the clinical outcomes associated with current immune therapeutics."

"We are very impressed by the data from this recent study," said Colin Meyer, M.D., Vice President of Product Development at Reata Pharmaceuticals, Inc. "These findings are a significant advance in our understanding of the fundamental basis by which tumors escape immune surveillance, and these preclinical data with one of our AIM class compounds are highly encouraging."

About Reata Pharmaceuticals
Reata Pharmaceuticals is the leader in discovering and developing novel, oral anti-inflammatory drugs that activate Nrf2, the primary regulator of cellular antioxidant and detoxification enzymes. Activation of this important biological target is thought to protect against a broad range of diseases associated with inflammation and oxidative stress. Reata's lead product candidate, bardoxolone methyl, was initially studied in cancer patients. In these studies, cancer patients with moderate to severe chronic kidney disease (CKD) demonstrated marked improvement in a key measure of kidney function.  On the basis of these observations, Reata initiated development of bardoxolone methyl in patients with advanced CKD, and the drug is currently in a global Phase 3 clinical trial. Reata is advancing a second generation AIM to be used in clinical development for the treatment of cancer patients.

For more information, please visit the company's Web site at http://www.reatapharma.com/.

Reata Contacts

Media: Matt Middleman,

SOURCE Reata Pharmaceuticals
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