Navigation Links
New Study Points to Novel Mechanism by Which Tumors Escape Recognition by the Immune System
Date:11/29/2011

IRVING, Texas, Nov. 29, 2011 /PRNewswire/ -- A new study in The Journal of Clinical Investigation (JCI) has uncovered a novel mechanism that cancer cells may use to escape detection by the body's immune system. The study, "Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice," led by researchers at the H. Lee Moffitt Cancer Center in Tampa, Fla., shows that a specific type of immature white blood cells (myeloid derived suppressor cells or "MDSCs") are recruited to tumors where they modify tumor cells so that they are no longer recognized by the immune system's cells (cytotoxic T cells) that fight cancer. The study also suggested that bardoxolone methyl, the lead compound in a new class of molecules called antioxidant inflammation modulators (AIMs), may have the ability to prevent these modifications and thereby boost the immune system's ability to detect and fight cancer.

In previous studies, the authors, Dr. Dmitry Gabrilovich and colleagues, showed that oxidative stress produced by MDSCs inhibited tumor recognition by the immune system (Nature Medicine, 2007). The findings in the new study demonstrate how this occurs. Oxidative stress produced by MDSCs alters the surface proteins on tumor cells so that cytotoxic T cells can no longer recognize the tumor. The authors hypothesized that reducing oxidative stress in the tumor microenvironment would prevent alteration of tumor surface proteins and thereby restore the immune system's ability to recognize the tumor. The authors chose to use one of Reata's AIM class compounds to lower oxidative stress because it is a potent activator of Nrf2 and inhibitor of NFκB, thereby reducing oxidative stress and suppressing inflammation. In mice with lung cancer or melanoma, treatment with the AIM improved the ability of cytotoxic T cells to recognize tumor cells and significantly slowed tumor growth. This approach may be important in addressing other tumor types because MDSC activity has been shown in numerous cancers, including pancreatic cancer, breast cancer, lung cancer and melanoma.

Commenting on the study results, Dr. Gabrilovich said, "Our study not only demonstrated a novel mechanism by which the tumor escapes recognition by the immune system but also suggested a potential approach to its correction, which may improve the clinical outcomes associated with current immune therapeutics."

"We are very impressed by the data from this recent study," said Colin Meyer, M.D., Vice President of Product Development at Reata Pharmaceuticals, Inc. "These findings are a significant advance in our understanding of the fundamental basis by which tumors escape immune surveillance, and these preclinical data with one of our AIM class compounds are highly encouraging."

About Reata Pharmaceuticals
Reata Pharmaceuticals is the leader in discovering and developing novel, oral anti-inflammatory drugs that activate Nrf2, the primary regulator of cellular antioxidant and detoxification enzymes. Activation of this important biological target is thought to protect against a broad range of diseases associated with inflammation and oxidative stress. Reata's lead product candidate, bardoxolone methyl, was initially studied in cancer patients. In these studies, cancer patients with moderate to severe chronic kidney disease (CKD) demonstrated marked improvement in a key measure of kidney function.  On the basis of these observations, Reata initiated development of bardoxolone methyl in patients with advanced CKD, and the drug is currently in a global Phase 3 clinical trial. Reata is advancing a second generation AIM to be used in clinical development for the treatment of cancer patients.

For more information, please visit the company's Web site at http://www.reatapharma.com/.

Reata Contacts

Media: Matt Middleman, matt.middleman@russopartnersllc.com, 212-845-4272

Investors: Alan Roemer, aroemer@troutgroup.com, 646-378-2945

 


'/>"/>
SOURCE Reata Pharmaceuticals
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
3. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
4. Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma
5. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
6. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
7. Study Suggests High-Dose Fish Oil May Significantly Improve Behavior in Children with ADHD
8. MicroDose Announces Positive Results From the QDose Inhaled Insulin Glucose Clamp Study
9. Video: Landmark Study in The Lancet: Patients Treated With Betaseron(R) After First MS Attack Experienced Significant Delay in MS Progression
10. MacroGenics Begins Global Phase 2/3 Protege Study in Recent-onset Type 1 Diabetes Mellitus
11. Sarasotas Roskamp Institute Releases Study Defining a Mechanism for Development of Obesity and the Metabolic Syndrome, Forerunners of Type 2 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)... , June 23, 2016 Research ... Devices Global Market - Forecast to 2022" report to ... the treatment method for the patients with kidney failure, it ... excess fluid from the patient,s blood and thus the treatment ... potassium and chloride in balance. Increasing number ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... Forecast to 2022" report to their offering. ... date financial data derived from varied research sources to present ... impact on the market during the next five years, including ... sub markets, regional and country level analysis. The report provides ...
(Date:6/23/2016)... and INDIANAPOLIS , June 23, 2016 ... Lilly Diabetes Tomorrow,s Leaders Scholarship is any indication, the ... announced today online at www.diabetesscholars.org by the ... diabetes stand in the way of academic and community ... Foundation,s scholarship program since 2012, and continues to advocate ...
Breaking Medicine Technology:
(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer ... through a fitness app. The fitness app plans to fix the two major problems leading ... a one size fits all type program , They don’t eliminate all the ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, can ... Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey ... cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the ... Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. , “We ... new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice ...
(Date:6/25/2016)... ... 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland ... iHire in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness ... & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of ...
(Date:6/24/2016)... ... , ... Those who have experienced traumatic events may suffer from a complex ... as drug or alcohol abuse, as a coping mechanism. To avoid this pain and ... a traumatic event. , Trauma sufferers tend to feel a range of emotions, from ...
Breaking Medicine News(10 mins):