Navigation Links
New Study Findings Could Help Millions Who Suffer From Dry Mouth: Over-The-Counter Muco-Adhesive Patch Outperforms Leading Oral Rinse
Date:3/22/2010

EUGENE, Ore., March 22 /PRNewswire/ -- A newly developed time-released muco-adhesive patch for treating oral health conditions, including the widespread condition of dry mouth (xerostomia), has been shown to be more effective than a leading oral rinse, according to a newly-published study. As increasing segments of the population consume more medications (one of the leading causes of dry mouth), the results of this study could potentially help provide relief for millions of Americans. Chronic dry mouth impacts the quality of life and for some, can be debilitating. Published in the March 2010 issue of Quintessence International,(1) the study found that chronic dry mouth sufferers can now get a statistically significant reduction of mouth dryness from a new time-released muco-adhesive patch (OraMoist Dry Mouth Patch), compared with the leading oral rinse which has been on the market for nearly two decades.

Overall, patients with xerostomia treated with the muco-adhesive patch reported a statistically significant reduction in mouth dryness sensation with elevated salivary flow rate (150%) after just 30 minutes, which was considered clinically outstanding by the study authors, since the product does not contain any cholinergic agonist, a drug often used to treat dry mouth.

OraMoist, a new time-released, non-drug formula, not only outperformed the mouthwash, one of the most often used delivery formats for treating dry mouth, but unlike dry mouth sprays, rinses or gels, which need to be applied frequently – sometimes every 20 minutes – OraMoist works to increase moisture and help restore a healthy oral environment for hours at a time, day or night, and can even be used by those with dental appliances, such as dentures. It moistens and lubricates the mouth with time-released lipids, citrus oil and sea salt, while simultaneously stimulating saliva production and inhibiting bacterial growth and promoting oral health with enzymes and xylitol.

"Oral disorders such as dry mouth and canker sores require long residence of the active remedy in the mouth or the disease site for effective treatment. Muco-adhesive patches made of safe ingredients that adhere to the oral mucosal tissue and slowly erode while releasing active remedies for two to six hours provide the desired residence time for effective therapy," said Professor Abraham J. Domb, PhD, Institute of Drug Research, School of Pharmacy, Faculty of Medicine at the Hebrew University, co-author of the new published study, inventor of the muco-adhesive time-released patch and world-renowned for his work in biodegradable polymers. "This novel approach of time-released delivery has proven to be a successful and desirable approach to treating chronic conditions that affect millions of people, and can be disruptive to their lifestyle."

The evolution of the muco-adhesive patch has found commercial viability in treating canker sores as well because the patch can also act as a bandage for the sores for eight to twelve hours while releasing active remedial ingredients.

Dry mouth affects upwards of 17% of the population, increasing in older adults (65 years and older) to about 30%. In fact, 34% of people taking three or more medications suffer from dry mouth, which is also a chronic symptom of numerous medical conditions, such as diabetes and Sjogren's Syndrome.

Study Findings

The objective of this study was to evaluate a muco-adhesive lipid-based bioerodable patch as a novel device to decrease signs and symptoms associated with dry mouth, compared to the leading oral rinse. The study consisted of 20 patients who suffered from dry mouth for more than three months as a result of medical conditions, who were divided into two treatment groups – oral rinse and muco-adhesive patch.

  • The questionnaires completed prior to treatment showed no statistically significant differences between the groups
  • Following treatment, 40% of muco-adhesive patch users reported significantly more moisture and a reduction in the sensation of dry mouth vs. 20% of the leading mouthwash users
  • There was a 1.5-fold increase in unstimulated whole saliva flow (UWSF) after 30 minutes in the group using the muco-adhesive patch
  • In addition, 70% of patients treated with the muco-adhesive patch reported they would continue using the product in the future, compared to only 30% who would continue using the leading mouthwash

For more information about dry mouth and OraMoist, visit www.oramoist.com.

(1) Doron J. Aframian, DMD, PhD; Boaz Mizrahi, PhD; Igal Granot, DMD; Abraham J. Domb, PhD, "Evaluation of a mucoadhesive lipid-based bioerodable tablet compared with Biotene mouthwash for dry mouth relief – a pilot study," Quintessence International, March 2010.

SOURCE OraMoist

Back to top

RELATED LINKS
http://www.oramoist.com

'/>"/>

SOURCE OraMoist
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Simcere Pharmaceutical Group Successfully Completes Endostar Phase IV Clinical Study
2. R&D Investment by U.S. Biopharmaceutical Companies Increases to Record $65.3 Billion, Study Finds
3. Medco, Mayo Clinic Study Reveals Using a Simple Genetic Test Reduces Hospitalization Rates by Nearly a Third for Patients on Widely Prescribed Blood Thinner
4. Study Shows Superior Efficacy for TAXUS(R) Express(R) Stents at One Year Compared to Bare-Metal Stents in Diabetic Patients Experiencing Heart Attack
5. Chimerix Initiates Phase 2 Study of CMX001 in Stem Cell Transplant Recipients Seropositive for Cytomegalovirus
6. Genomic Health Announces Publication of Study Using Oncotype DX(R) in Node-Negative and Node-Positive Breast Cancer Patients Treated With Aromatase Inhibitors
7. ReShape Medical Announces Initiation of U.S. Clinical Study for Weight Loss
8. New Study Links dLife to Increased Rx Drug Usage Among Diabetes Consumers
9. Study Shows Pine Bark Naturally Reduces Blood Pressure and Counteracts Kidney Damage Caused by Hypertension
10. TechniScan Launches 3-D Breast Ultrasound Clinical Study in Freiburg University
11. New Study Demonstrates Safety of Balloon Sinuplasty(TM) Technology in Pediatric Patients Suffering From Chronic Sinusitis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2016)... According to a new ... Product (Wheelchair, Scooters, Medical Beds, Bathroom Safety, Mechanical, ... Wound), Accessories (Lifting, Transfer) & by End User ... MarketsandMarkets, the patient handling equipment market is expected ... a CAGR of 10.5% during the forecast period ...
(Date:5/23/2016)... , May 23, 2016 Diplomat Pharmacy, Inc. ... annual Fellowship and Internship programs. The hands-on learning experience ... The full-time, paid Fellowship and ... Michigan . Fellows and interns are provided optional ... Flint at the Riverfront Residence Hall ...
(Date:5/23/2016)... , May 23, 2016 ... Size, Share, Development, Growth and Demand Forecast to ... and Other), by Application (Drug Discovery and Development, ... Users (Pharmaceuticals, Life Science and Biotechnology, Academic and ... Market Research, the global mass spectrometry market ...
Breaking Medicine Technology:
(Date:5/26/2016)... ... May 26, 2016 , ... OncLive® ... added National Cancer Institute-designated University of Virginia (UVA) Cancer Center to ... OncLive’s editorial and marketing teams will publicize and promote public awareness of UVA ...
(Date:5/26/2016)... ... 26, 2016 , ... Workrite Ergonomics announced today that Phil ... develop their rapidly expanding portfolio of customer and end user accounts. ... and an M.B.A. with concentration in management from Bryant University in Smithfield, Rhode ...
(Date:5/26/2016)... ... , ... Dr. LeRoy Perry’s recently authored whitepaper, “Tech Neck and ROI (return ... of users, hundreds of millions of whom are coming into the workplace with pain ... common action of looking down at hand-held technology devices (tablets, smartphones) for extended periods ...
(Date:5/26/2016)... CA (PRWEB) , ... May 26, 2016 , ... In ... him running plumbing calls throughout the beach community. His vision to grow the company ... rates and ensuring they maintain the highest level of training and customer service. Over ...
(Date:5/26/2016)... ... May 26, 2016 , ... TopConsumerReviews.com ... Blood Pressure products . , High blood pressure affects millions of people worldwide, ... blood pressure can lead to heart disease, stroke, kidney disease, and hardening of ...
Breaking Medicine News(10 mins):