Navigation Links
New Study Explores Impact of More Uniform Distribution of Endovascular Coils in Cerebral Aneurysm Treatment
Date:6/21/2011

RAYNHAM, Mass., June 21, 2011 /PRNewswire/ -- A new study published in the June edition of the Journal of NeuroInterventional Surgery(1) highlights that a more uniform distribution of endovascular coils may help in the treatment of cerebral aneurysms, it was reported by Codman & Shurtleff, Inc. (Codman), a global neurovascular and neuroscience company.  Codman's DELTAPAQ™ endovascular microcoils were used in the study.

Study authors found that the novel triangular primary wind design of DELTAPAQ™ endovascular microcoils achieved a tighter packing density and a more uniform distribution of the coil mass across the aneurysm dome in comparison with helical and complex endovascular microcoils.  DELTAPAQ coils were also more likely to have the highest rate of angiographic occlusion.  

Researchers concluded that the evaluation of emerging coil technologies with respect to treatment durability may be well served by an assessment of their uniformity of distribution within an aneurysm, in addition to the traditional packing density and angiographic occlusion scoring methods.  

"This study suggests that the uniformity across the dome of the aneurysm may play an important role in enhancing the durability of endovascular treatment and is an important area for further study and confirmation," said Bernard R. Bendok, MD, study co-author and Associate Professor of Neurological Surgery and Radiology at Northwestern University's Feinberg School of Medicine.*  "The application of a coil uniformity model may provide valuable design information."  

Study authors constructed silicone aneurysm models and devised an assessment tool to objectively measure the coil uniformity index, which when combined with the degree of angiographic occlusion and packing density, can provide valuable information regarding coil behavior.

In the in vitro study, DELTAPAQ coils were more uniformly distributed in the dome of the aneurysm than were the complex (CASHMERE®) and helical (HELIPAQ®) coils.  The average packing density for DELTAPAQ (39.1 %) was significantly higher than the complex (35.2%) and helical (32.2 %) coil systems.  In addition, DELTAPAQ had the highest rate of angiographic occlusion (Class 1) based on the Raymond score, a qualitative measure of permeability.

"This study encourages clinicians and industry to look at the coil uniformity index, in addition to packing density and occlusion rates, when deciding which endovascular coil to use," said Karen Prange, General Manager and Vice President, Codman Neurovascular.  "Codman remains committed to design innovation and supporting research that advances the understanding of neurovascular care.  We are pleased to see that the DELTAWIND technology performed favorably in this assessment model."

The study was funded by a research grant from Micrus Endovascular, Inc. which now operates under Codman Neurovascular, a Codman business.  

In addition to Dr. Bendok, study authors include:  Manik Mehra, MD, Matthew J. Gounis, PhD, and Robert M. King, BS, from the New England Center for Stroke Research, University of Massachusetts Medical School; Ali Shaibani, MD, Michael C. Hurley, MD, and Guilherme Dabus, MD, from Northwestern University's Feinberg School of Medicine; Elad I. Levy, MD, School of Medicine and Biomedical Sciences, University of New York, Buffalo; and Fatimaezzahra E. Labdag, BS, from Micrus Endovascular, Inc.    

Endovascular coils are inserted directly into an aneurysm through a microcatheter, a small, thin, hollow tube, to block blood flow and prevent rupture, which could lead to a hemorrhagic stroke, a life-threatening condition that affects about 13 percent of the 800,000 stroke cases each year in the United States. (2)   According to the American Stroke Association, cerebral aneurysms affect 3 to 5 million people in the United States.(3)  

About Codman & Shurtleff, Inc.

Codman is a global neuroscience and neurovascular company that develops and markets a wide range of products and solutions for the diagnosis and treatment of neurological disorders including chronic pain management, adult and pediatric hydrocephalus, neuro critical care, stroke prevention and management.  Codman is part of the DePuy Family of Companies within Johnson & Johnson.  The DePuy Family of Companies has a rich heritage of pioneering a broad range of products and solutions across the continuum of orthopaedic and neurological care.  Visit www.codman.com and www.depuy.com for more information.

*Paid consultant to Codman

(1) Mehra M, Hurley MC, Gounis MJ, et al. "The impact of coil shape design on angiographic occlusion, packing density and coil mass uniformity in aneurysm embolization: an in vitro study." J NeuroIntervent Surg 2011;3:131-136.

(2) American Stroke Association. Hemorrhagic Stroke. Available from: http://www.strokeassociation.org/STROKEORG/AboutStroke/TypesofStroke/HemorrhagicBleeds/Hemorrhagic-Bleeds_UCM_310940_Article.jsp.

(3) American Stroke Association. "What You Should Know About Cerebral Aneurysms." June 2009. Available from: http://www.strokeassociation.org/STROKEORG/AboutStroke/TypesofStroke/HemorrhagicBleeds/What-You-Should-Know-About-Cerebral-Aneurysms_UCM_310103_Article.jsp.


'/>"/>
SOURCE Codman & Shurtleff, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
3. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
4. Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma
5. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
6. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
7. Study Suggests High-Dose Fish Oil May Significantly Improve Behavior in Children with ADHD
8. MicroDose Announces Positive Results From the QDose Inhaled Insulin Glucose Clamp Study
9. Video: Landmark Study in The Lancet: Patients Treated With Betaseron(R) After First MS Attack Experienced Significant Delay in MS Progression
10. MacroGenics Begins Global Phase 2/3 Protege Study in Recent-onset Type 1 Diabetes Mellitus
11. Sarasotas Roskamp Institute Releases Study Defining a Mechanism for Development of Obesity and the Metabolic Syndrome, Forerunners of Type 2 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2016)... , April 27, 2016 ... a developer of a new generation of drugs ... overall survival results for Paclical/Apealea in the Phase ... patients with epithelial ovarian cancer. These preliminary results ... in combination with carboplatin versus Taxol in combination ...
(Date:4/27/2016)... SAN FRANCISCO , April 27, 2016 /PRNewswire/ ...  is expected to reach USD 2.06 billion by ... View Research, Inc. Increasing consumer awareness towards a ... over the next seven years.      ... Improper diet intake coupled with rising health treatment ...
(Date:4/26/2016)... , April 26, 2016 Diplomat Pharmacy, ... of Jennifer Hagerman , Pharm D., to Vice ... growing role at Diplomat, Hagerman will continue to lead ... company that delivers custom education and training to Diplomat ... specialty pharmacy industry. Diplomat University also houses the quality ...
Breaking Medicine Technology:
(Date:4/28/2016)... ... April 28, 2016 , ... ... Year at VitaFoods 2016. , Nominated in the Healthy Ageing category, Cognizin® is ... and safety. The Healthy Ageing division can include everything from antioxidants, lipids, proteins, ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... Sharing and Collaboration Platform™ , today announced a new Residency Education & ... access to medical knowledge, educational resources, and a host of collaboration tools ...
(Date:4/28/2016)... ... 28, 2016 , ... Metabolic Nutrition today announced the upcoming launch ... Europa Games Get Fit and Sports Expo in Orlando, Florida. Attended by ... up April 29-30, was selected as the perfect event to introduce the highly anticipated ...
(Date:4/28/2016)... ... 2016 , ... For the 10,000 Americans who turn 65 on any given ... overall well-being: mental health. Now, a new book—Staying Sharp For Dummies (Paper; ISBN: 978-1-119-18779-0; ... which can include everything from honing your memory and managing stress to eating healthy ...
(Date:4/28/2016)... ... 2016 , ... For many, a diet is only as good as it looks. No matter ... good. In addition, an individual cannot deny the importance of maintaining a healthy diet and ... worked to create a product range that could entice people to eat clean and enjoy ...
Breaking Medicine News(10 mins):