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New Study: Pine Bark Extract Boosts Nitric Oxide (NO) Production
Date:10/17/2007

Research shows Pycnogenol(R) boosts healthy NO production, increasing blood

flow, muscle oxygen supply

HOBOKEN, N.J., Oct. 17 /PRNewswire/ -- A study to be published in the October edition of Hypertension Research reveals Pycnogenol(R), (pic-noj-en-all), an antioxidant plant extract from the bark of the French maritime pine tree, helps individuals by enhancing healthy nitric oxide (NO) production which leads to an increase in blood flow and oxygen supply to muscles.

Nitric oxide, a key cardiovascular chemical produced by the body, increases blood flow that serves to deliver more nutrients and oxygen to the muscles, helping muscles to cope with increased physical activity and build when subjected to regular elevated labor.

"This study suggests that when taking Pycnogenol(R), more NO is provided in response to neurotransmitters allowing for better expansion of arteries to carry more blood. This process serves to meet the enhanced oxygen demand of the performing muscle and avoid anaerobic metabolism," said Dr. Yukihito Higashi, lead researcher of the study. "These results also lead me to determine that Pycnogenol(R) will be a useful natural alternative therapy in various diseases in which oxidative stress is involved in the pathogenesis."

The double-blind, randomized, placebo study was held at the Hiroshima University Graduate School of Biomedical Sciences in Japan. Every day for two weeks young healthy men either took 180 mg Pycnogenol(R) or a placebo. To identify Pycnogenol's(R) effect on the release of NO, an inhibitor of the amino acid L-arginine was infused in patients, which restricts the expansion of arteries in response to the neurotransmitter acetylcholine.

After two weeks of supplementation with Pycnogenol(R), results revealed blood flow increased in response to acetylcholine stimulation by 42 percent. In contrast, the control group receiving the placebo did not show a pronounced blood flow increase
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SOURCE Natural Health Science Inc.
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