Navigation Links
New Study: Antidepressants Commonly Prescribed with Tamoxifen Put Women at Much Higher Risk for Recurrent Breast Cancer
Date:5/30/2009

- Several SSRIs more than double risk of cancer recurrence in tamoxifen treated patients

- Nearly 30 percent of tamoxifen users take drugs that reduce its effectiveness against breast cancer

ORLANDO, Fla., May 30 /PRNewswire-FirstCall/ -- An important new study finds that certain popular antidepressants frequently prescribed to women taking the breast cancer drug tamoxifen more than double the risk of a breast cancer recurrence for those using both medications. The research presented by Medco Health Solutions, Inc. (NYSE: MHS) and Indiana University School of Medicine at the 2009 Annual Meeting of the American Society of Clinical Oncology (ASCO) is the largest study to date looking at how these drugs impact breast cancer recurrence rates when taken with tamoxifen.

The antidepressants at issue are three widely used selective serotonin reuptake inhibitors (SSRIs), Prozac(R) (fluoxetine), Paxil(R) (paroxetine) and Zoloft(R) (sertraline), and are among a group of drugs known as CYP2D6 inhibitors. Antidepressants are often prescribed with tamoxifen to treat depression - a common co-morbidity of the disease, as well as hot flashes - a common side-effect of the breast cancer drug.

The three drugs that pose this risk for women on tamoxifen are considered to be moderate to potent CYP2D6 inhibitors. Several other SSRIs examined in the study that are weak CYP2D6 inhibitors did not raise breast cancer recurrence risks for patients using them along with tamoxifen. Those SSRIs included Celexa(R) (citalopram), Lexapro(R) (escitalopram) and Luvox(R) (fluvoxamine).

"We've known that these CYP2D6 inhibitor drugs block the activation of tamoxifen chemically, but this is the first time there's evidence that these drugs are putting women at a much higher risk for recurrent breast cancer
'/>"/>

SOURCE Medco Health Solutions, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. New Study: Pine Bark Significantly Reduces Menstrual Pain
2. New Study: Pine Bark Extract Boosts Nitric Oxide (NO) Production
3. New Research Shows Antidepressants May Thwart Breast Cancer Treatment
4. New Study Evaluating the ADHD Medication VYVANSE(R) (lisdexamfetamine dimesylate) CII Demonstrated No Change in the Pharmacokinetic Profile of VYVANSE When Coadministered with Prilosec OTC(R) 40 mg (20 mg X 2), a Commonly Used Proton Pump Inhibitor (PPI)
5. New Data Show Doripenem as Effective as Commonly Used Therapies in Treating Hospital-Acquired Pneumonias
6. New Studies Show Popular Heartburn Medications Moderate the Effect of Taking Widely Prescribed Heart Drug
7. Video: Femara(R) First Aromatase Inhibitor to Indicate Survival Benefit Versus Tamoxifen When Taken for Five Years After Breast Cancer Surgery
8. VIDEO: Femara(R) helps protect against return of breast cancer even when treatment starts several years after completing tamoxifen therapy
9. Genomic Health Study Shows Breast Cancers in Men Display Very Similar Gene Signatures to Those in Women
10. CVS Caremark Data Confirms Improved Outcomes for Women with Osteoporosis Who are Adherent to Therapy
11. Methadone Frequently Causes Menopausal Symptoms in Young Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... , Sept. 17, 2014  Decision ... colitis (CD/UC) patients eligible for biologic therapy, ... a biologic. Surveyed gastroenterologists cite patients, discomfort ... for low penetration rates, followed by cost-related ... UC patients receiving biologics, Janssen Biotech,s Remicade ...
(Date:9/17/2014)... Sept. 17, 2014  Rebiotix Inc. announced this morning that ... product candidate, RBX2660 (microbiota suspension) will be presented in two ... in Philadelphia from October 8-12. ... the poster session on Thursday, October 9, 2014: ... Infection: 60-Day Interim Analysis of the PUNCH-CD Phase 2 Safety ...
(Date:9/17/2014)... , Sept. 17, 2014   OTEMR, Inc. , ... Complete EHR certification, which designates that the software is ... 1 and Stage 2 Meaningful Use measures required to ... Act (ARRA).  ONETOUCH EMR 2.0 was certified on July ... of the National Coordinator-Authorized Certification Body (ONC-ACB) and is ...
Breaking Medicine Technology:The Majority of Surveyed Gastroenterologists Agree that Biologics Should be Prescribed to More Patients in the Crohn's Disease and Ulcerative Colitis Treatment Paradigm 2The Majority of Surveyed Gastroenterologists Agree that Biologics Should be Prescribed to More Patients in the Crohn's Disease and Ulcerative Colitis Treatment Paradigm 3PUNCH CD Study Drug Targeting Recurrent C. difficile Infection to be Presented at IDWeek 2014 2PUNCH CD Study Drug Targeting Recurrent C. difficile Infection to be Presented at IDWeek 2014 3PUNCH CD Study Drug Targeting Recurrent C. difficile Infection to be Presented at IDWeek 2014 4OTEMR, Inc.'s ONETOUCH EMR Achieves ONC HIT 2014 Edition COMPLETE EHR Certification from ICSA Labs 2OTEMR, Inc.'s ONETOUCH EMR Achieves ONC HIT 2014 Edition COMPLETE EHR Certification from ICSA Labs 3
... recommendations for knee and ... hip osteoarthritis, ... MT. LAUREL, N.J., Feb. 19 A newly released set ... worldwide who live in pain due to inconsistent treatment,approaches and confusion ...
... Feb. 19 Joseph F. Finn, Jr.,CPA, the ... announced,today the design of a clinical trial to ... approved antibiotics. Rifalazil, the,most potent anti-chlamydial agent that ... treatment option for Chlamydia STD. The insidious aspect,of ...
Cached Medicine Technology:Osteoarthritis: Which Treatments Work and Which Don't? 2Osteoarthritis: Which Treatments Work and Which Don't? 3ActivBiotics Outlines a Clinical Path Forward to Examine if Rifalazil Is Superior to Azithromycin in the Treatment of Chlamydia STD 2
(Date:9/18/2014)... DC (PRWEB) September 18, 2014 “ ... as part of its monthly Biz Report, which ... to consumers. Scott Steinberg, a host of NewsWatch and ... how these high quality lenses can save users hundreds ... Eyewear, a San Francisco company creates fashion-forward glasses ...
(Date:9/17/2014)... Today, Fecbek, a leading dress manufacturer and ... occasion gowns. These are a lot of beautiful A-line dresses, ... range. , A skirt is a tube- or cone-shaped ... part of the legs. In the western world, skirts are ... a draped garment which is made out of a single ...
(Date:9/17/2014)... Dr. Shalev is a Texas native, and grew ... at the University of Texas, and graduated with a Bachelors ... real passion lay in dentistry, and she went on to ... Texas Health Science Center at Houston School of Dentistry. Dr. ... of The Greater Houston Dental Society, and the Texas Dental ...
(Date:9/17/2014)... 18, 2014 ADVOCATE, the premier ... announces today that they have been awarded the ... in Fort Wayne, Indiana. , ADVOCATE ... encompassing their proprietary suite of billing process software ... improves radiology billing and data quality consistency by ...
(Date:9/17/2014)... Pittsburgh, PA (PRWEB) September 17, 2014 ... their exercise - even when they're already practicing or ... I was inspired to design a special fitness system ... or playing baseball or football," said an inventor from ... the MOBILITY FITNESS SYSTEM, which maximizes a body workout ...
Breaking Medicine News(10 mins):Health News:NewsWatch Recently Featured the Fashion-Forward Frames “Francis Drake Eyewear” on National Television 2Health News:Fecbek.com Has Recently Announced Its New Series of Delicate Special Occasion Gowns Online 2Health News:ADVOCATE Wins Radiology Billing Agreements with Fort Wayne Radiology 2Health News:ADVOCATE Wins Radiology Billing Agreements with Fort Wayne Radiology 3
... Society report outlines 21 challenges and needs for global tobacco ... and expertise needed to reduce the rising tide of tobacco ... are the target of the multinational tobacco industry. The report ... issue of CA: A Cancer Journal for Clinicians . ...
... Genital herpes caused by a reactivation of herpes simplex ... lesion in one specific area of the genital region. ... frequently reactivate throughout the genital tract, an important new ... prevention. Now available online ( http://www.journals.uchicago.edu/doi/abs/10.1086/650302 ), the study ...
... is associated with increased cancer risk. The most ... noted for a common form of liver cancer called ... obesity in mice, researchers at the University of California, ... obesity is tumor-promoting and have obtained evidence that this ...
... Hasbro Children,s Research Center and Hasbro Children,s Hospital researchers ... from The Eunice Kennedy Shriver National Institute of Child ... of asthma on the sleep quality and academic performance ... pediatric researchers, led by Daphne Koinis-Mitchell, PhD, to evaluate ...
... reduce the transmission of influenza-like illness during flu season. ... online ( http://www.journals.uchicago.edu/doi/abs/10.1086/650396 ), published in the Feb. 15 ... In an influenza pandemic, vaccination may not be ... is why scientists need to understand how effective other ...
... The BC Centre for Disease Control has launched ... the pandemic H1N1 flu virus has evolved in British ... months. This project capitalizes on BC,s expertise and ... genomes from circulating influenza viruses collected in British Columbia ...
Cached Medicine News:Health News:Global tobacco report outlines 21 challenges for 21st century 2Health News:Global tobacco report outlines 21 challenges for 21st century 3Health News:Study shows genital herpes virus reactivates widely throughout genital tract 2Health News:Link between obesity and enhanced cancer risk elucidated 2Health News:New research will examine link between childhood asthma, sleep and school performance 2Health News:Study finds face masks and hand hygiene can help limit influenza's spread 2Health News:Genomic surveillance of pandemic H1N1 2
... Ultracentrifuge power for small-volume samples. With ... method of removing chylomicrons (fat particles in ... results for lipemic clarification. Lipemic samples can ... need for sendouts. The easy-to-operate tabletop ...
... Dimension Xpand integrated chemistry system brings ... to the smaller laboratory. A model ... Xpand integrated chemistry system features state-of-the-art ... low-volume testing environment, in a flexible, ...
The Dimension RxL Max is an integrated chemistry system and is the most powerful and technologically advanced Dimension analyze with new standard for excellence in clinical diagnostics. Simply put, t...
... Dimension clinical chemistry integrated systems combine the ... cartridge, the power of the Multiply and ... the heterogeneous module to meet the challenges ... broad test menus, the systems can meet ...
Medicine Products: