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New Studies Presented at European Society of Anaesthesia Further Validate Masimo PVI(TM) for Noninvasive and Continuous Fluid Monitoring
Date:6/12/2009

udy concluded that "Our results suggest that an accurate prediction of fluid responsiveness can be obtained non-invasively using the PVI."(1)

The Change of Upper Limbs PVI in Spinal Block (Comparison in High Spinal Block and Non-High Spinal Block)

At the Tokai University School of Medicine in Tokyo, Japan, researchers examined how PVI in the upper limbs of patients undergoing caesarean procedures for hernia surgery changed in response to the level of spinal block reached. PVI was recorded in all patients before and every two minutes after spinal block was performed. In patients reaching the anesthetic level C-area--identified as the high spinal block group--PVI decreased. In patients who did not reach the C-area--identified as the non-high spinal block group--PVI of the upper limbs did not change significantly. Researchers summarized that high spinal block dilates vessels and increases blood flow in the upper limbs, which in turn, is shown by decreased PVI.(2)

Perfusion Index and Pleth Variability Index After Administration of General Anesthetic Agents

In this study, anesthesiologists at the Teikyo University School of Medicine in Tokyo, Japan, analyzed changes in PVI and Masimo perfusion index (PI) in 21 surgical patients before and after administration of general anesthetic agents. After administration of general anesthetic agents and 10ml/kg/hr of fluid during induction, PVI significantly decreased from 22.9=/+8.1 to 17.1=/+7.2 (p<0.05) and PI significantly increased from 2.1=/+1.7 to 3.8=/+2.3 (p<0.001), leading researchers to conclude that "an increase in peripheral perfusion and improvement of fluid status and preload" occurred "after administration of general anesthetic agents and intravenous fluid administration during anesthesia induction."(3)

Michael O'Reilly, MD, EVP of Medical Affairs at Masimo, stated; "These studies confirm what previous results have
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