Navigation Links
New Studies Demonstrate Clinical Utility and Validity of CancerType ID® Molecular Classifier
Date:3/22/2012

VANCOUVER, Canada, March 21, 2012  – bioTheranostics, Inc. announced today findings from three key studies. Results, presented at the United States and Canadian Academy of Pathology (USCAP) annual meeting, showed that CancerTYPE ID® had strong clinical utility and demonstrated a high level of accuracy for tumor classification and sub-classification. Tumor classification and sub-classification are important criteria in treatment selection with the advent of site- and subtype-specific therapies.

CancerTYPE ID is a standardized, objective, 92-gene molecular cancer classifier that classifies a broad range of distinct tumors by matching the gene expression pattern of a patient's tumor to a database of gene expression information from known tumor types and subtypes.

In a large retrospective analysis (USCAP 2012 Abstract # 429), researchers found that current immunohistochemistry (IHC) practices are non-standardized in protocol, interpretation and in time to completion, further underscoring a significant need for additional analytical approaches to aid in resolving indeterminate and differential diagnoses. Results indicate that more than seven IHC stains were associated with longer-than-average time to diagnosis but were not associated with increased diagnostic resolution.

The researchers further noted that an assay database with broad tumor coverage would be an important consideration for clinicians, as CancerTYPE ID predicted 23 main tumor types and 42 subtypes in the 754 cases reviewed.

In a second study, a multi-institutional analysis and the most comprehensive validation of a molecular classifier to date, CancerTYPE ID demonstrated excellent performance for classification of a diverse set of tumors (USCAP 2012 Abstract # 1888) that was consistent with previous validation results. The study reviewed 790 cases in collaboration with the Mayo Clinic, the University of California, Los Angeles (UCLA) and Massachusetts General Hospital (MGH).

The same researchers also evaluated the use of CancerTYPE ID to predict the site of origin for primary and metastatic tumors with neuroendocrine differentiation (USCAP 2012 Abstract # 604). Findings from this analysis indicated CancerTYPE ID may address an unmet medical need as a molecular correlate for sub-typing neuroendocrine tumors. The ability to subtype neuroendocrine tumors, among the most difficult to determine, has important implications for grading, staging and disease management.

"The 92-gene classifier demonstrated excellent accuracy for subtyping tumors with neuroendocrine differentiation," said Mark Erlander, PhD, Chief Scientific Officer of bioTheranostics. "While these results were part of a larger parent study designed to characterize performance of the classifier in a broad range of tumor histologies, these findings show promise for use of the 92-gene assay in classifying neuroendocrine tumors of uncertain primary site."

"In these recent studies, CancerTYPE ID's accuracy was also noted in both metastatic as well as poorly differentiated primary tumors, and its diagnostic value was maintained even in situations where there was limited tissue," said Richard Ding, Chief Executive Officer of bioTheranostics. "We believe this is an important step in discovering where a molecular classifier, such as CancerTYPE ID, fits in the diagnostic picture as an accurate, objective and time-saving adjunctive pathology asset. We appreciate the independent and growing support from pathologists in utilizing CancerTYPE ID as a standardized diagnostic aid in their workup of metastatic cancers."

About bioTheranostics

Advancing Molecular Diagnostics in Oncology

bioTheranostics discovers, develops and commercializes molecular diagnostic tests for cancer patients. Leveraging its unique expertise in expression profiling and algorithm development, bioTheranostics provides innovative tests to the oncology community. The company operates a CLIA-certified, CAP-accredited diagnostic service laboratory in San Diego, CA to perform its proprietary molecular diagnostic tests: breastcancerindex, which is a prognostic test that provides quantitative risk assessment of distant recurrence in patients diagnosed with estrogen receptor positive and lymph node negative breast cancer; and CancerTYPE ID, which uses the differential expression of 92 genes to aid in the determination of tumor site of origin. For more information, call 1-858-587-5870 or visit www.bioTheranostics.com.

About bioMerieux

Advancing Diagnostics to Improve Public Health

A world leader in the field of in vitro diagnostics for more than 45 years, bioMerieux is present in more than 150 countries through 39 subsidiaries and a large network of distributors. In 2011, revenues reached euro 1.427 billion with 87% of sales outside of France.

bioMerieux provides diagnostic solutions (reagents, instruments, software) which determine the source of disease and contamination to improve patient health and ensure consumer safety. Its products are used for diagnosing infectious diseases and providing high medical value results for cancer screening and monitoring and cardiovascular emergencies. They are also used for detecting microorganisms in agri-food, pharmaceutical and cosmetic products.

bioMerieux is listed on the NYSE Euronext Paris market (Symbol: BIM – ISIN: FR0010096479).

Other information can be found at www.biomerieux.com

FOR INFORMATION:

bioTheranostics
Tim Schofield
Tel: + 1 858 587 5890
tim.schofield@biotheranostics.com

bioMerieux
Koren Wolman-Tardy
Tel: + 011 33 6 13 94 51 14
media@eu.biomerieux.com


'/>"/>
SOURCE bioTheranostics, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Carrington Subsidiary DelSite Initiates Critical Toxicology Studies of Its Nasal Powder Bird Flu Vaccine
2. Advanced Life Sciences to Present Data on Selected Cethromycin Therapeutic Studies at the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy
3. Sucampo Pharmaceuticals, Inc. Begins Pivotal Phase III Studies of Oral Lubiprostone to Treat Opioid-Induced Bowel Dysfunction (OBD)
4. Schering-Plough Initiates Phase III Studies with Vicriviroc in Treatment- Experienced HIV Patients
5. Phase 2 Clinical Studies Initiated for a Novel Therapeutic Candidate Identified Through Pharmacopeia Collaboration
6. Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC
7. Studies Suggest Key Correlation Between Lung Cancer Subtype and Treatment Outcomes
8. Isis Announces $1.2 Million Award to Its Ibis Subsidiary to Expand Influenza Detection Capabilities and Enable Large-Scale Influenza Transmission Studies
9. Pharmasset Commences Dosing in Phase 3 Registration Studies of Clevudine for HBV
10. Studies Show Body Mass Index Has No Effect on Resolution and Healing of GERD Symptoms
11. Amicus Therapeutics Announces Positive Results From Two Phase 1 Clinical Studies of AT2220 for Pompe Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/27/2017)... , Sept. 27, 2017  Commended for their devotion to ... awards. Ranked as number one in the South Florida Business ... in Inc. 5000 yearly list, the national specialty pharmacy has ... Armando Bardisa will soon be honored by SFBJ as ... Set to receive his award in October, ...
(Date:9/23/2017)... HORSHAM, Pa. , Sept. 22, 2017 ... received a complete response letter from the U.S. Food ... (BLA) seeking approval of sirukumab for the treatment of ... response letter indicates additional clinical data are needed to ... of moderately to severely active RA. ...
(Date:9/19/2017)... Ky. , Sept. 19, 2017   ZirMed Inc ... predictive analytics, today announced that it has been ranked #1 ... Black Book™ Rankings 2017 User Survey. ZirMed was ... solution for large hospitals and medical centers over 200 beds ... Black Book,s healthcare technology user survey history. ...
Breaking Medicine Technology:
(Date:10/12/2017)... WILMINGTON, Del. (PRWEB) , ... October 12, 2017 ... ... technology and advisory services for healthcare compliance program management, will showcase a range ... and National Association for Assisted Living (NCAL) Convention and Expo to be held ...
(Date:10/12/2017)... ... , ... IsoComforter, Inc. ( https://isocomforter.com ), one of the Nation’s ... design of the shoulder pad. The shoulder pad provides optimal support and full ... while using cold therapy. By utilizing ice and water that is circulated from an ...
(Date:10/12/2017)... ... 12, 2017 , ... Dr. Parsa Mohebi, the Los Angeles ... to the newly revamped Cosmetic Town journal section, featuring articles written ... known as Follicular Unit Extraction (FUE). , Dr. Mohebi says “I ...
(Date:10/12/2017)... ... October 12, 2017 , ... Women-owned and Grand Rapids-based workplace ... Brightest in Wellness® by Best and Brightest. OnSite Wellness will be honored at ... from 7:30 a.m. to 2 p.m. at the Henry Autograph Collection Hotel, located ...
(Date:10/12/2017)... ... October 12, 2017 , ... Farm Forward ... and other leading institutions in announcing the launch of the Leadership Circle ... way animals are raised for food. , Founding members of the Leadership Circle ...
Breaking Medicine News(10 mins):