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New Studies Demonstrate Clinical Utility and Validity of CancerType ID® Molecular Classifier
Date:3/22/2012

VANCOUVER, Canada, March 21, 2012  – bioTheranostics, Inc. announced today findings from three key studies. Results, presented at the United States and Canadian Academy of Pathology (USCAP) annual meeting, showed that CancerTYPE ID® had strong clinical utility and demonstrated a high level of accuracy for tumor classification and sub-classification. Tumor classification and sub-classification are important criteria in treatment selection with the advent of site- and subtype-specific therapies.

CancerTYPE ID is a standardized, objective, 92-gene molecular cancer classifier that classifies a broad range of distinct tumors by matching the gene expression pattern of a patient's tumor to a database of gene expression information from known tumor types and subtypes.

In a large retrospective analysis (USCAP 2012 Abstract # 429), researchers found that current immunohistochemistry (IHC) practices are non-standardized in protocol, interpretation and in time to completion, further underscoring a significant need for additional analytical approaches to aid in resolving indeterminate and differential diagnoses. Results indicate that more than seven IHC stains were associated with longer-than-average time to diagnosis but were not associated with increased diagnostic resolution.

The researchers further noted that an assay database with broad tumor coverage would be an important consideration for clinicians, as CancerTYPE ID predicted 23 main tumor types and 42 subtypes in the 754 cases reviewed.

In a second study, a multi-institutional analysis and the most comprehensive validation of a molecular classifier to date, CancerTYPE ID demonstrated excellent performance for classification of a diverse set of tumors (USCAP 2012 Abstract # 1888) that was consistent with previous validation results. The study reviewed 790 cases in collaboration with the Mayo Clinic, the University of California, Los Angeles (UCLA) and Massachuse
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SOURCE bioTheranostics, Inc.
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