Navigation Links
New Risk Gene for Rheumatoid Arthritis and Lupus Opens Door to More Effective Treatments
Date:9/6/2007

MANHASSET, N.Y., Sept. 6 /PRNewswire-USNewswire/ -- Scientists at The Feinstein Institute for Medical Research have identified a critical gene that increases a person's risk for rheumatoid arthritis and systemic lupus erythematosus, and may be involved with other autoimmune diseases.

The genetic link, described in the September 6th issue of the New England Journal of Medicine, was a collaborative effort led by Peter K. Gregersen, MD, head of The Feinstein Institute's Robert S. Boas Center for Genomics & Human Genetics. A decade ago, Dr. Gregersen helped bring together scientists from a dozen institutes to pool patients and add strength in numbers as they collectively hunt for genes. More recently, the North American Rheumatoid Arthritis Consortium (NARAC) studied a region identified on chromosome 2 in previous linkage studies conducted by the same team. In the latest study, they analyzed DNA from 2,500 patients with rheumatoid arthritis (RA) or lupus. Genetic mapping enabled them to identify STAT4 as a culprit in susceptibility to both diseases.

"This work required the collection and genotyping of thousands of RA and lupus patients and volunteers, a task that would have been difficult to accomplish without the strong partnerships we forged," said Stephen I. Katz, MD, PhD, director of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). The federal institute has supported NARAC since its inception.

"Identifying STAT4 as the relevant gene on chromosome 2 is very exciting," added Elaine Remmers, PhD, a lead author in the NEJM study on STAT4 and a staff scientist in the NIAMS's Genetics and Genomics Branch. "We now are faced with trying to figure out how this variant of STAT4 increases a person's risk."

About 22 percent of people in the United States inherit this particular form of STAT4. Having this variant of STAT4 confers a 30 percent increased risk for developing rheumatoid arthritis. People with two copie
'/>"/>

SOURCE The Feinstein Institute for Medical Research
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Actemra (tocilizumab) Third Phase III Study Results Show Significant Improvement in Symptoms of Patients with Rheumatoid Arthritis
2. Three Studies Suggest Abbotts Humira (adalimumab) May Improve Work Productivity in Patients with Rheumatoid Arthritis
3. GlaxoSmithKline and Genmab Present Positive Phase II Results With ofatumumab in Patients With Rheumatoid Arthritis (RA)
4. Actemra (tocilizumab) Significantly Improves Symptoms of Rheumatoid Arthritis Compared to a Current Standard of Care
5. Anti-TNF Golimumab Continues to Show Promise in Phase II Rheumatoid Arthritis Study
6. Cimzia Effective in Reducing Signs and Symptoms of Rheumatoid Arthritis
7. Three New Drugs Mark New Era in Rheumatoid Arthritis Treatment
8. Enbrel Safety Data for up to Eight Years in Patients with Juvenile Rheumatoid Arthritis Being Presented at EULAR
9. New Data Confirms Significant Improvement of Disease Signs and Symptoms in Patients with Rheumatoid Arthritis
10. New Data on Genmab and GlaxoSmithKlines Ofatumumab: Phase II Study in Rheumatoid Arthritis to be Presented at EULAR
11. Rigel Provides Clinical Update of R788 Phase 2 Trials in ITP, Rheumatoid Arthritis and Lymphoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... HAMILTON, N.J. , Oct. 22, 2014 ... CLIA-certified, CAP-accredited laboratory which specializes in high ... that it is now offering new Cystic ... including next- generation DNA sequencing platforms. ... a genetically inherited multisystem disorder that affects ...
(Date:10/22/2014)... , Oct 22, 2014 Antigen Discovery ... Irvine, California , announced the receipt of a ... Innovation Research award (SBIR) from the National Institute of Dental and ... the development of a Pan-HIV Protein Microarray Chip, which ... and HIV-2 subtypes and aid in the development of ...
(Date:10/22/2014)... AVACEN Medical announced today that its AVACEN ... clearance by the U.S. Food and Drug Administration. This ... the Internet for: the temporary relief of joint ... and sprains . Logo - http://photos.prnewswire.com/prnh/20141021/153513 ... is a sophisticated medical device incorporating over 3,000 firmware ...
Breaking Medicine Technology:Medical Diagnostic Laboratories, L.L.C. Institute for Biomarker Research Announces New Prenatal Cystic Fibrosis Tests 2Biomarker Discovery Company, Antigen Discovery Inc., Awarded an NIH Phase I Small Business Innovation Research Grant to Develop a Pan-HIV Protein Microarray Chip 2AVACEN Medical Announces FDA Clearance of First Medical Device with Internal Game Mode 2
... International,Inc. (NYSE: BAX ) announced today that ... IX proteins to treat hemophilia B.,Baxter will develop ... of acute bleeding episodes and a chemically modified, ... of bleeding in,hemophilia B patients. Hemophilia B is ...
... Nanoparticles May Deliver Treatments to Human,Organs -, PHILADELPHIA, ... iron-bearing particles to drive healthy cells to,targeted sites in ... to,a new method of delivering cells and genes to ... http://www.newscom.com/cgi-bin/prnh/20080107/DC10966 ), The study team, led by ...
Cached Medicine Technology:Baxter Announces Recombinant Factor IX Development Program For Hemophilia B 2Baxter Announces Recombinant Factor IX Development Program For Hemophilia B 3Researchers Use Magnetism to Target Cells to Animal Arteries 2Researchers Use Magnetism to Target Cells to Animal Arteries 3Researchers Use Magnetism to Target Cells to Animal Arteries 4
(Date:10/25/2014)... October,s shorter, darker days can trigger a type of ... expert. People affected by seasonal affective disorder, ... and even have trouble getting out of bed. In ... Angelos Halaris, a professor in the department of psychiatry ... of Medicine. "Seasonal affective disorder should not be ...
(Date:10/22/2014)... On October 22, CBS will air ... diseases both fictional and real. The Charles E ... committed to advocacy and philanthropy in the battle against ... opportunity to impart truth and clarity about this misunderstood ... many misconceptions about Morgellons Disease (MD) and ...
(Date:10/22/2014)... 2014 For Dr. Iris Hunter, a job ... an extension of her life’s mission. Her extensive experience in ... owner of FirstLight HomeCare, make it clear that Hunter’s mission ... that my work makes a difference in the lives of ... so after much research, I felt ready to start on ...
(Date:10/22/2014)... Lexington, Kentucky (PRWEB) October 22, 2014 ... an agreement that will change the current location of ... Road to South Limestone across from the University of ... be a state-of-the-art ambulatory care center, owned and operated ... meet the orthopaedic needs of children and their families ...
(Date:10/22/2014)... D.C. (PRWEB) October 22, 2014 With the ... a national survey by the American Institutes for Research (AIR) ... know how to use health insurance, but 42 percent say ... a plan’s details before signing up for coverage. , The ... with only 20 percent able to calculate correctly how much ...
Breaking Medicine News(10 mins):Health News:Dark Days Here for Folks With Seasonal Depression 2Health News:CBS’ Criminal Minds takes aim at skin disease with Morgellons in the Mix 2Health News:CBS’ Criminal Minds takes aim at skin disease with Morgellons in the Mix 3Health News:Dr. Iris Hunter to Host Grand Opening of FirstLight HomeCare Tomorrow 2Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 2Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 2Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 4
... told yesterday about a surgeon Dr Jerome Blanchard who had ... only a diseased one. , ,The disciplinary hearing ... the wrong kidney from a patient and left her dependent ... medical notes. Dr Jerome Blanchard took out his patient’s transplant ...
... conclusion drawn by the doctors after treating 65 million ... therapy// to bring the blood pressure to normal range ... ,A number of clinical studies since long has shown ... Professor of Medicine; Brigham and Women’s Hospital and Harward ...
... Dutch study contradicts the popular belief that the effect ... impact on the soldier’s partner and children//. It highlights ... any significant way. ,Psychiatrist Arend Veeninga, in ... no scientific basis to the theory that ‘war trauma ...
... has been found to suppress bladder pain associated with ... is a analog of a metabolite of THC, the ... study presented at the annual meeting of the American ... in the treatment of hypersensitive bladder disorders and similar ...
... its presence in the Indian market and gain wider acceptability, ... punch of health// to its India portfolio, possibly by early ... beverage solutions in the non-alcohol segment. This would include not ... Cola India chief Atul Singh told PTI here. ...
... Manchester feel that Statins, A cholesterol-lowering drug should be prescribed ... reduce the heart diseases. ,The researchers looked at ... the mid-1990s, and recorded how many of them had a ... calculate as to how many people would need to have ...
Cached Medicine News:Health News:Consultant Bungles A Kidney Surgery 2Health News:Combination Drug Therapy For Hypertension 2Health News:Bladder Pain Suppressed By Marijuana-Derived Drug 2Health News:A New Study Feels That The UK heart drug Guidelines Not Enough 2
... sunwear, inspired by modern American ... with long lasting wearability. The ... include sophistication, elegance and enduring ... modern shapes, classic styling and ...
... mounting technology has redefined rimless collections forever.,The ... at the end of each frame mounting. ... the bushing that mounts within the lens. ... secure fit is created that far exceeds ...
... collection celebrates the 85th anniversary of the ... feel, the unmistakable icons that made GUCCI ... and sunglass collection, dedicated to a multifaceted ... design that is the hallmark of the ...
... Whisper NG Erbium YAG Extended Ablation laser ... true laser peel with outstanding results and no ... a proprietary fluence level with an extra long ... skin. Peeling is spread over 3-5 days, ...
Medicine Products: