Navigation Links
New Review of Idebenone as a Novel Therapeutic Approach for Duchenne Muscular Dystrophy
Date:1/12/2016

LONDON, January 12, 2016 /PRNewswire/ --

European Neurological Review, the peer-reviewed journal, has published a review highlighting the promising studies of idebenone as a novel therapeutic approach for Duchenne muscular dystrophy

     (Logo: http://photos.prnewswire.com/prnh/20151014/276718LOGO)

Abstract: 

Progressive loss of pulmonary function leads to early morbidity and mortality in Duchenne muscular dystrophy (DMD) due to both expiratory impairment with ineffective airway clearance, and inspiratory impairment leading to nocturnal and daytime hypoventilation and respiratory failure. Glucocorticoid steroids have become a mainstay of DMD therapy with well-documented efficacy on muscle strength and respiratory function. However, the side-effect profile restricts their long-term use, particularly in non-ambulant patients. Idebenone improves secondary mitochondrial dysfunction caused by dystrophin deficiency, intracellular calcium accumulation and increased reactive oxygen species (ROS). Idebenone-mediated improved bioenergetics leads to enhanced adenosine triphosphate (ATP) production and reduced ROS. Based on this rationale, idebenone has been investigated clinically for efficacy on reducing respiratory function decline in exploratory phase II (DELPHI) and confirmatory phase III (DELOS) trials. Idebenone significantly reduced the loss of respiratory function in 8-18-year-old DMD patients who were not using concomitant glucocorticoids. These results indicate that idebenone can modify the natural course of respiratory disease progression in DMD, which is relevant in clinical practice where loss of respiratory function continues to be a predominant cause of early morbidity and mortality in DMD.

The full peer-reviewed, open-access article is available here:

http://doi.org/10.17925/ENR.2015.10.02.189

Note to the Editor

touchNEUROLOGY (a division of Touch Medical Media) publishes

European Neurological Review, a peer-reviewed, open access, bi-annual journals specialising in the publication of balanced and comprehensive review articles written by leading authorities to address the most important and salient developments in the field of neurology. The aim of these reviews is to break down the high science from 'data-rich' primary papers and provide practical advice and opinion on how this information can help physicians in the day to day clinical setting. Practice guidelines, symposium write-ups, case reports, and original research articles are also featured to promote discussion and learning amongst physicians, clinicians, researchers and related healthcare professionals.

www.touchNEUROLOGY.com

Providing practical opinion to support best practice for busy healthcare professionals.

 

For inquires please contact:

Carla Denaro - Managing Editor

managingeditor@touchmedicalmedia.com

T: +44-(0)207-193-6093

 


'/>"/>
SOURCE touchNEUROLOGY.com
Copyright©2016 PR Newswire.
All rights reserved


Related medicine technology :

1. Review of Delcath Melphalan/HDS System Published in "Cardiovascular & Interventional Radiology"
2. Rigel Reviews Recent Progress and Announces Presentation at the 34th Annual J.P. Morgan Healthcare Conference in San Francisco
3. Polymedco Introduces New Quality Control Peer Review Program
4. AcelRx Pharmaceuticals Receives Notice of Eligibility for Centralized Review of ARX-04 from European Medicines Agency
5. Polymyositis Clinical Trials Review H2 2015 Market Research Report
6. Tibial Plateau Fracture Market Clinical Trials Review Report for H2 2015
7. Global Membrane Market in Pharmaceutical Industry CAGR Growth of 12.46% by 2019 - Review, Trends & Opportunities 2015-2019
8. Spinal Cord Injury Therapeutic Development Pipeline Review Report
9. China Diabetes Market Report - Industry Review, Analysis & Forecasts 2015
10. Braeburn Pharmaceuticals And Titan Pharmaceuticals Announce Date Of FDA Advisory Committee Review Of Probuphine For Opioid Addiction
11. Delcath Announces CHEMOSAT Review Accepted for Publication in Cardiovascular and Interventional Radiology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/15/2018)... ... 15, 2018 , ... During a special ceremony at the ... Illinois, was named the grand prize winner of the 2018 IsaBody Challenge®. The ... a global health and wellness company providing nutrition and lifestyle solutions. , ...
(Date:8/14/2018)... ... August 14, 2018 , ... ... commitment of more than $270,000 to expand a popular pet therapy program. ... full-time coordinator to facilitate more visits to patients throughout the hospital and outpatient ...
(Date:8/11/2018)... ... August 10, 2018 , ... Last month, Dr. Tim Herman, ... to deliver dental care in underserved communities surrounding its capital of Asunción. Along with ... Dr. Herman volunteered his time to help deliver care to over 550 individuals in ...
Breaking Medicine Technology:
(Date:8/7/2018)... ... August 07, 2018 , ... The American ... selected to receive the 2018 Board of Directors Student Scholarship . The ... of psychiatric-mental health nursing and develop the next generation of leaders in the ...
(Date:8/3/2018)... ... 2018 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, ... the Bible meant only to be understood in this current generation. Yisrayl says he ... decode passages that he says scholars have struggled with for generations. Yisrayl says the ...
(Date:8/2/2018)... Pa. (PRWEB) , ... August 02, 2018 , ... ... lifeIMAGE medical image e-sharing platform to connect clinicians inside and outside ... patients suffering a life-threatening stroke or trauma. , AHN joins other leading hospital ...
(Date:8/2/2018)... Conn. (PRWEB) , ... August 02, 2018 , ... ... (TGA) to its prestigious Top 20 Training Delivery Companies of 2018 . ... “Our mission is to empower training industry professionals with the game-based tools they ...
(Date:8/2/2018)... ... August 01, 2018 , ... Primary care practices in Rochester, ... makes actionable recommendations for victims and their doctors. , A team of researchers ... (RESOLVE) developed the software program. , “Family care practitioners are often the ...
Breaking Medicine News(10 mins):