Navigation Links
New Research Suggests That Acthar Reduces Proteinuria in Idiopathic Membranous Nephropathy In Part Through Suppression of Anti-PLA2R Antibodies
Date:11/10/2011

PHILADELPHIA, Nov. 10, 2011 /PRNewswire/ -- On November 10 at the American Society of Nephrology 44th Annual Meeting, Boston University Assistant Professor of Medicine Laurence H. Beck, Jr., M.D., Ph.D. will present results from a study which found that H.P. Acthar® Gel may induce a remission of proteinuria in patients with idiopathic membranous nephropathy (iMN) by suppressing production of antibodies to the phospholipase A2 receptor (PLA2R).  iMN is a common cause of nephrotic syndrome in adults.  Nephrotic syndrome is a known risk factor for progression to end-stage renal disease (ESRD).

"A high proportion of patients with idiopathic membranous nephropathy have circulating anti-PLA2R antibodies.  These antibodies attack a key protein located on the podocyte cells, which are found within the kidney and are directly involved in renal filtration," said Dr. Beck.  "We believe that anti-PLA2R antibodies are an important therapeutic target in the treatment of this form of chronic kidney disease.  The results of this study indicate that there appears to be a direct beneficial effect of Acthar on the immune system in patients with idiopathic membranous nephropathy."

Overall, the study included 14 patients with iMN from 2 pilot studies (Mayo Clinic and Columbia University Medical Center).  Patients were treated with Acthar for 6 months. In the study, 12 of 14 patients (86%) were anti-PLA2R positive at baseline.  All 12 patients with a baseline anti-PLA2R level experienced a reduction in anti-PLA2R by 6 months, with the complete disappearance of anti-PLA2R in 5 patients.  There were 5 patients with partial remission of proteinuria at 6 months.  Two additional patients with undetectable baseline anti-PLA2R serum levels did achieve clinical remission of proteinuria.  

"These findings provide a major step forward in the understanding of how patients with nephrotic syndrome due to idiopathic membran
'/>"/>

SOURCE Questcor Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Millar Instruments, Inc. and Telemetry Research Ltd Merge
2. Transparency Market Research: The North America and Europe Minimally Invasive Prostate Cancer Surgery Market is Booming: Expected to Attain a Market Size of USD 24.9 Billion by 2016
3. Childrens Hospital Boston and Pfizer Enter Into Novel Collaborative Research Agreement for Muscular Dystrophy Therapeutics
4. Adeona Senior Vice President of Research & Development to Present at American College of Nutrition Annual Meeting
5. SMT Research & Development, Ltd. Names Shuki Porath as Vice President and General Manager, Announces TCT Presence
6. Critical Alerts For Barrick Gold, Molycorp, Lockheed Martin, Teva Pharmaceutical, and Tenaris Released By Seven Summits Research
7. Kensey Nash Corporation Receives $1.9m NIH Grant for Tendon Product Research
8. Caliper Launches New Platform for Drug Safety Prediction and Oncology Research
9. JDRF and the Helmsley Charitable Trust Form a Collaboration to Accelerate Innovative Type 1 Diabetes Research and Development
10. Anaheim to Host Worlds Largest Gathering on Cystic Fibrosis Research and Care
11. Renal Research Institute Announces Scientific Presentations at the American Society of Nephrology Kidney Week
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... Calif. , July 10, 2014 Integrated ... leader in advanced memory and analog IC solutions, today ... on Thursday, July 24, 2014, at 7:00 a.m. Pacific ... financial results for the fiscal 2014 third quarter ended ... call via telephone, dial 1-888-556-4997 before 6:50 a.m. Pacific ...
(Date:7/10/2014)... , July 10, 2014  BC Technical, the largest ... MiE America , Inc., a leading provider of Siemens ... a long-term agreement naming BC Technical as the authorized ... MiE and BC Technical announced today that ... establish BC Technical as the service and systems provider ...
(Date:7/10/2014)... 10, 2014  Decision Resources Group finds that ... (ID) specialists are willing to prescribe Durata,s Dalvance ... use as OPAT, approximately two-thirds of the respondents ... their hospital inpatients. However, our findings indicate that ... initiated on OPAT following hospital discharge, and most ...
Breaking Medicine Technology:BC Technical Partners With MiE America To Be Authorized Provider Of Systems & Service 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3
... for Vidaza versus 26.2 for ... patients on Vidaza compared to ... compared to conventional ... Only epigenetic modifier to show survival benefit in cancer Stratified log-rank p-value = ...
... trial of AKIi-5 as the first human clinical study ... involving the systemic ... Quark Pharmaceuticals, Inc., a,clinical-stage biopharmaceutical company focused on discovering ... positive results from preclinical efficacy studies for its,proprietary systemically-administered, ...
Cached Medicine Technology:Vidaza Significantly Extends Overall Survival by 74% in Phase 3 Trial in Myelodysplastic Syndromes (MDS) 2Vidaza Significantly Extends Overall Survival by 74% in Phase 3 Trial in Myelodysplastic Syndromes (MDS) 3Vidaza Significantly Extends Overall Survival by 74% in Phase 3 Trial in Myelodysplastic Syndromes (MDS) 4Vidaza Significantly Extends Overall Survival by 74% in Phase 3 Trial in Myelodysplastic Syndromes (MDS) 5Vidaza Significantly Extends Overall Survival by 74% in Phase 3 Trial in Myelodysplastic Syndromes (MDS) 6Vidaza Significantly Extends Overall Survival by 74% in Phase 3 Trial in Myelodysplastic Syndromes (MDS) 7Vidaza Significantly Extends Overall Survival by 74% in Phase 3 Trial in Myelodysplastic Syndromes (MDS) 8Quark Pharmaceuticals, Inc. Presented Positive Preclinical Results of Systemic RNAi Compound for Acute Renal Failure (ARF) 2Quark Pharmaceuticals, Inc. Presented Positive Preclinical Results of Systemic RNAi Compound for Acute Renal Failure (ARF) 3Quark Pharmaceuticals, Inc. Presented Positive Preclinical Results of Systemic RNAi Compound for Acute Renal Failure (ARF) 4
(Date:7/11/2014)... Wild by Nature, a natural and organic supermarket owned by ... fifth store to be located in West Islip, NY very ... selections of wheat and gluten-free products available. With a growing ... become a one-stop shop for anyone who needs to be ... is a spectrum of disorders, including celiac disease, in which ...
(Date:7/11/2014)... LENEXA, Kan. (PRWEB) July 11, 2014 B. ... to healthcare providers, has been retained to lead a national ... Health System in Bend, Ore. The top executive ... has recently placed more than 900 healthcare executives into organizations. ... medical providers, St. Charles Health System is the largest provider ...
(Date:7/11/2014)... BellasDress, the experienced dressmaker in the ... suppliers when it comes to beach wedding dresses ... of beach wedding outfits in its online shop. Included ... outfits. , BellasDress has been considered as one ... to the company’s senior spokesman, BellasDress provides superb special ...
(Date:7/11/2014)... July 11, 2014 Wearing the school motto ... families, facility and staff came together this past Saturday morning ... Everest community in the Homer Township Independence Day Parade. ... Old Glory. , Everest community recognized the theme ... in red, white and blue. The blue Everest balloons ...
(Date:7/11/2014)... 2014 Growing old was thought of as a ... recent studies, it was shown that many of the “myths” ... As it turns out, the elderly can still live quite as ... with all the time in the world, older people also need ... their passions in the twilight of their lives. This is why ...
Breaking Medicine News(10 mins):Health News:Wild by Nature Opens New Location 2Health News:St. Charles Health System Retains B. E. Smith to Recruit New CNO 2Health News:St. Charles Health System Retains B. E. Smith to Recruit New CNO 3Health News:BellasDress Emerges As Popular Online Supplier Of 2014 Beach Wedding Dresses 2Health News:Everest Academy Participates in the Homer Township Independence Day Parade 2Health News:It’s All Free For Seniors Review, How To Take Advantage of What Life Has to Offer In Old Age – Vinamy.com 2Health News:It’s All Free For Seniors Review, How To Take Advantage of What Life Has to Offer In Old Age – Vinamy.com 3
... IL, Oct. 8 /PRNewswire-FirstCall/ - SXC Health Solutions ... TSX: SXC), a leading provider of,pharmacy benefits management ... recertified to provide PBM services to members,of the ... up of more than 60 large employers, representing ...
... adults seek prescription for,savings amid ailing economy, FRANKLIN LAKES, ... hit the hardest when it comes to the recent,economic crisis, ... MHS ),reveals that the sting in paying for health care ... young adults., According to the new national survey "Feeling ...
... satisfaction thanks to revolutionary computer imaging for http://www.parkercenter.net/plastic_surgery_procedures_rhinoplasty.html ... M. Parker, says "A nose should not draw attention to ... to your overall appearance, gender and ethnicity." , ... ...
... will host the 6th Canadian Annual Meeting (November 5-7; ... issues facing Health Canada, the pharmaceutical industry, health academia, ... ... Horsham, PA (PRWEB) October 8, ...
... as a technological leader in cosmetic skin treatments in New York City. ... one of the latest skin resurfacing treatments to receive FDA approval, to ... ... October 8, 2008 -- The cosmetic surgery and laser treatment industry is ...
... LAKE SUCCESS, N.Y., Oct. 7 IPRO, ... evaluation organizations, has,created a Limited Liability Company ... audit oversight and consulting contracts with managed ... (http://www.logiqual.com ), is now,officially incorporated in New ...
Cached Medicine News:Health News:SXC Health Solutions announces PBM certification from the HR Policy Association 2Health News:SXC Health Solutions announces PBM certification from the HR Policy Association 3Health News:New Survey: Painful Economy Puts Health Care Pinch on Young Adults 2Health News:New Survey: Painful Economy Puts Health Care Pinch on Young Adults 3Health News:New Survey: Painful Economy Puts Health Care Pinch on Young Adults 4Health News:New Survey: Painful Economy Puts Health Care Pinch on Young Adults 5Health News:New Jersey Rhinoplasty Patients Can Now See the Future at The Parker Center for Plastic Surgery New Jersey 2Health News:New Jersey Rhinoplasty Patients Can Now See the Future at The Parker Center for Plastic Surgery New Jersey 3Health News:New Jersey Rhinoplasty Patients Can Now See the Future at The Parker Center for Plastic Surgery New Jersey 4Health News:DIA 6th Canadian Annual Meeting Benefit and Risk Management: An Evolution in Progress 2Health News:Upscale New York City Skin Care Center Juva Offering FDA Approved Fraxel re:fine System 2Health News:IPRO Spins Off Managed Care Review Affiliate 2
The Aaron 800-EU is designed and engineered to be the most reliable and durable desiccator available today....
Sabre 180 is a powerful niche generator....
The Sabre 2400 provides high power performance and key user features to meet today's demanding electrosurgical needs. It is an ideal general-purpose electrosurgical generator....
The Sabre 2400 provides high power performance and key user features to meet today's demanding electrosurgical needs. It is an ideal general-purpose electrosurgical generator....
Medicine Products: