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New Research Suggests That Acthar Reduces Proteinuria in Idiopathic Membranous Nephropathy In Part Through Suppression of Anti-PLA2R Antibodies
Date:11/10/2011

PHILADELPHIA, Nov. 10, 2011 /PRNewswire/ -- On November 10 at the American Society of Nephrology 44th Annual Meeting, Boston University Assistant Professor of Medicine Laurence H. Beck, Jr., M.D., Ph.D. will present results from a study which found that H.P. Acthar® Gel may induce a remission of proteinuria in patients with idiopathic membranous nephropathy (iMN) by suppressing production of antibodies to the phospholipase A2 receptor (PLA2R).  iMN is a common cause of nephrotic syndrome in adults.  Nephrotic syndrome is a known risk factor for progression to end-stage renal disease (ESRD).

"A high proportion of patients with idiopathic membranous nephropathy have circulating anti-PLA2R antibodies.  These antibodies attack a key protein located on the podocyte cells, which are found within the kidney and are directly involved in renal filtration," said Dr. Beck.  "We believe that anti-PLA2R antibodies are an important therapeutic target in the treatment of this form of chronic kidney disease.  The results of this study indicate that there appears to be a direct beneficial effect of Acthar on the immune system in patients with idiopathic membranous nephropathy."

Overall, the study included 14 patients with iMN from 2 pilot studies (Mayo Clinic and Columbia University Medical Center).  Patients were treated with Acthar for 6 months. In the study, 12 of 14 patients (86%) were anti-PLA2R positive at baseline.  All 12 patients with a baseline anti-PLA2R level experienced a reduction in anti-PLA2R by 6 months, with the complete disappearance of anti-PLA2R in 5 patients.  There were 5 patients with partial remission of proteinuria at 6 months.  Two additional patients with undetectable baseline anti-PLA2R serum levels did achieve clinical remission of proteinuria.  

"These findings provide a major step forward in the understanding of how patients with nephrotic syndrome due to idiopathic membran
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SOURCE Questcor Pharmaceuticals, Inc.
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