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New Research Shows PET Imaging Effective in Predicting Lung Cancer Outcomes
Date:10/5/2011

ve sugar molecule (known as FDG). Since most cancer cells take up sugar at a higher rate than normal cells, areas of tumor typically light up brightly on PET scans.  

The researchers found that the post-treatment scan was predictive for patients' prognosis by identifying that patients with high levels of FDG uptake following treatment had more aggressive tumors that were more likely to recur.  The researchers found that the higher the standard uptake value (SUV) for FDG in the primary tumor, the greater the recurrence rate and the lower the survival rate of patients.

The results also showed that there was a strong correlation between the radiation dose intensity and local control of the cancer, indicating that further research needs to be conducted in radiation technology for lung cancer.

"This is one of the largest studies of its kind to show that PET scans have great potential in predicting the prognosis for patients with inoperable lung cancer," says Dr. Machtay.  "It supports the theory that PET scans add an important new dimension to a physician's ability to determine which patients need additional cancer therapies to best manage their disease."

Among the nation's leading academic medical centers, University Hospitals Case Medical Center is the primary affiliate of Case Western Reserve University School of Medicine, a nationally recognized leader in medical research and education. National Cancer Institute-funded research is awarded through Case Western Reserve University.

Co-authors on the study are: F. Duan, B. Snyder, J. Gorelick, ACRIN Biostatistics Center/Brown University School of Medicine, Providence, RI; A. S. DeNittis, Main Line Health-Lankenau Institute for Medical Research, Wynnewood, PA; C. Chiles, Wake Forest University School of Medicine, Radiology, Winston-Salem, NC; I. Mahon, ACRIN, Philadelphia, PA; A. Alavi, University of Pennsylvania Medical School (Nuclear medicine/radi
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SOURCE University Hospitals Case Medical Center
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