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New Research Reveals Extent of Poor-Quality Antimalarial Medicines in South American Countries
Date:8/1/2012

h of primaquine poses a safety concern to individuals who are glucose-6-phosphate dehydrogenase deficient. This antimalarial medicine was also found in Guyana; it is not registered in the countries nor is part of their national treatment guidelines. All samples in Guyana and Suriname were collected between June and August 2009.

"These findings point to significant problems in the quality of antimalarials available in private and informal sector facilities in Guyana and Suriname," said Lawrence Evans, Ph.D., the study's lead author. "Besides the presence of medicines not included in the World Health Organization malaria treatment guidelines, the ease with which medications were procured without accurate diagnosis poses another major risk to patients' safety. In addition, this could have serious implications for the development of drug-resistant strains of Plasmodium parasites, particularly Falciparum, as novel treatments are not foreseeable in the near future."

The second study, Implementation of Basic Quality Control Tests for Malaria Medicines in Amazon Basin Countries: Results for the 2005-2010 Period, looks at the quality of malaria medicines in seven South American countries over a five-year period. In this study, basic analytical tests were utilized as a rapid and low-cost screening mechanism to identify substandard or counterfeit medicines. Performing basic tests is the first stage in a quality control framework developed by PQM for use in developing countries.

From 2005 to 2010, the quality of a total of 1,663 malaria medicines sampled in Bolivia, Brazil, Colombia, Ecuador, Guyana, Suriname and Venezuela was evaluated. The medicines sampled comprised all the therapies included in countries' therapeutic guidelines, and were mostly collected from the public sector (1,445, or 86.9 percent). In all, 193 (11.6 percent) were found not to meet quality specifications, of which only 51 (three percent) failed analytical tests;
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SOURCE U.S. Pharmacopeial Convention
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