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New Published Study Finds Noninvasive Masimo PVI Accurately Predicts Fluid Responsiveness in Intensive Care Patients
Date:2/1/2011

IRVINE, Calif., Feb. 1, 2011 /PRNewswire/ -- Masimo (Nasdaq: MASI) announced today that a new study published in the peer-reviewed journal Critical Care Medicine demonstrates that noninvasive, continuous monitoring of Masimo Pleth Variability Index (PVI®) predicts fluid responsiveness with high sensitivity (95%) and specificity (91%) in mechanically-ventilated patients in the Intensive Care Unit (ICU).(1)   Multiple previous studies have shown that PVI predicts fluid responsiveness in surgical patients—helping clinicians improve fluid management to reduce patient risk,(2, 3, 4) but this is the first published study demonstrating its effectiveness in predicting fluid responsiveness in critically-ill ICU patients.  

Hemodynamic instability is a common problem for critically-ill patients, but the decision to administer fluid in an attempt to improve cardiac output is challenging. When necessary, fluid administration is critical to optimizing patient status and enabling end organ preservation, but unnecessary fluid administration is associated with increased morbidity and mortality.  However, other dynamic indicators for assessing intravascular fluid volume are either invasive, operator dependent, costly, or unreliable predictors of whether a patient will benefit from fluid administration.

Citing numerous prospective studies showing that "only half of critically-ill patients respond to fluid boluses deemed necessary by attending physicians," researchers from CHU de Poitiers (France) acknowledged the "need for simple, noninvasive, and continuous bedside monitoring capable of detecting fluid responsiveness early in virtually all ICU patients, including those without an arterial catheter" in undertaking the current study. PVI provides clinicians with a
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