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New Prostate Cancer Treatment Drugs Could Pack Double Punch
Date:2/17/2012

eceptors. Patient trials with MDV3100 proved improved survival rates by nearly five months. Further, the drug caused tumor shrinkage in close to 30 percent of men, a 50 percent decline in PSA level, and an overall reduction in risk of death by 37 percent.

Improved survival rates of three to five months may sound minimal, but these drugs each present a significant opportunity for men with a disease that, in its advanced stages, can progress very quickly. What's more, experts believe using these drug therapies in a layered approach could provide even greater impact on survival rates for men with metastatic castration-resistant prostate cancers over the next few years.

"In recent months, we've seen the launch of various drug therapies targeting metastatic prostate cancer," said Dr. Samadi, "but the combined survival benefits, tumor shrinkage, and bone improvements with these drugs could lead to a double punch approach. Unlocking the power of how they might work together could mean longer and better lives for these patients." Further research will be conducted to evaluate the extent to which combining or sequencing Ra-223 and MDV3100 would provide additional survival and health benefits.

Prostate cancer is believed to be a hormone-fed disease that thrives in the presence of testosterone. Castration-resistant prostate cancer is named for its resistance to testosterone-lowering treatment therapies.

As a robotic prostatectomy expert, Dr. Samadi addressed the limited benefits of late-stage advancements by saying, "The more we do on the front end of this disease – improving diagnostic tools, getting behind the PSA test for early diagnosis, strengthening treatment choices – the less need there would be for costly drugs that offer relatively short-term returns."

Based on both drugs' exemplary trial results and limited side effects, experts are hopeful
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SOURCE RoboticOncology.com
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