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New Pre-Clinical and Clinical Data on GeNO LLC's Nitric Oxide Delivery Systems to Be Presented at 2013 American College of Cardiology and American Thoracic Society Medical Meetings
Date:1/29/2013

ry cartridge technology. These experiments demonstrate that nitric oxide derived from liquid N2O4 is equally efficacious as nitric oxide derived from NO2 gas in lowering mean pulmonary arterial pressure (mPAP) and PVR in a mammal.  The amount of nitric oxide generated with 0.2 ml of N2O4 is enough to deliver nitric oxide for >24 hours at flow rates used for nasal cannula delivery systems. 

"A Phase 2 Open Label Pilot Study Evaluating Preliminary Safety and Performance of the GeNO Nitrosyl Delivery System" will be presented at the American Thoracic Society International Conference in Philadelphia, PA on May 20, 2013.  This is the first clinical study to demonstrate that inhaled nitric oxide can be delivered in adult pulmonary arterial hypertension (PAH) patients with GeNO's inhaled nitric oxide delivery system in combination with approved PAH therapies with expected selective acute pulmonary hemodynamic effects.

"The data to be presented at these meetings provide important new insights into the clinical utility of ultrapure, inhaled nitric oxide delivered by GeNO's nitric oxide delivery system," said Dr. David Fine , Chief Executive Officer, GeNO LLC .

Dr. Robert Roscigno , Executive Vice President of Clinical Development, GeNO LLC, stressed that "as we advance this investigational product into late stage clinical trials for various forms of Pulmonary Hypertension, additional therapeutic options are still needed.  These data support further clinical development of GeNO's technologies for use by patients in need of acute and chronic Pulmonary Hypertension therapies."

In 2012, GeNO announced that its New Drug Application (NDA) for the GeNOsyl™ MVG-2000 Nitric Oxide Delivery System for neonates with hypoxic respiratory failure had been accepted
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